Novel Combinatorial Screening for NTFs, NPCs, MMPs, and CCs in relevance to Autoantibodies in the Serum and CSF of Veterans with GWI
Gulf War Illness (GWI) encompasses various neuromuscular symptoms. Several studies have been conducted so far to delineate the cause of these symptoms, but as of yet, treatment strategies have been unsatisfactory. We hypothesized that the repetitive exposures to various chemicals, even at non-lethal doses can inhibit acetylcholinesterase (AChE) irreversibly. Prophylactic treatments with reversible AChE inhibitors such as pyridostigmine bromide, anti-nerve gas pills, anti-inflammatory glucocorticoids, corticosterone, insect repellents like DEET and various vaccines not only prime the immune system, paradoxically trigger the CNS-glymphatic system to mount neuroinflammatory responses in some individuals. The goal of this project is to identify and estimate neural factors in the serum/plasma and CSF from veterans with Gulf War Illness (GWI) and to characterize the interaction of the immune components that can trigger an immune response. This study intends to identify immune complexes glycosylation and phosphorylation sites to determine how it regulates neurotransmitters and other neural factors that may contribute to this multisymptom disorder and compare with other related illness.