The Journal of Pharmacology and Experimental Therapeutics
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Publication Venue For
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Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension..
366:66-74.
2018
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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor..
335:351-361.
2010
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Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels..
332:698-709.
2010
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Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism..
322:16-22.
2007
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Enantiomeric metabolic interactions and stereoselective human methadone metabolism..
321:389-399.
2007
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Presynaptic delta opioid receptors regulate ethanol actions in central amygdala..
320:917-925.
2007
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Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis..
318:956-965.
2006
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Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors..
317:369-377.
2006
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Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes..
316:835-842.
2006
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Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats..
316:601-607.
2006
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Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase..
315:553-562.
2005
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Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties.
314:1274-1289.
2005
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Morphine side effects in beta-arrestin 2 knockout mice..
314:1195-1201.
2005
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Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography..
312:355-365.
2005
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Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury..
310:1266-1272.
2004
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Novel ceramide analogs as potential chemotherapeutic agents in breast cancer..
309:523-532.
2004
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Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex..
308:529-537.
2004
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Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs..
306:1-7.
2003
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Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats..
305:323-330.
2003
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The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics..
304:547-559.
2003
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Erratum: Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase (Journal of Pharcology and Experimental Therapeutics (2002) 301 (1166-1179)).
302:406.
2002
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Functional selectivity of dopamine receptor agonists. I. selective activation of postsynaptic dopamine D-2 receptors linked to adenylate cyclase (vol 301, pg 1166, 2002).
302:406-406.
2002
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The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals..
302:174-179.
2002
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Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase..
301:1166-1178.
2002
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Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs..
301:1179-1189.
2002
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Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex..
300:124-133.
2002
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells..
298:976-985.
2001
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Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation..
298:1021-1032.
2001
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Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine..
297:291-298.
2001
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Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites..
297:410-422.
2001
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Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A..
296:592-599.
2001
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Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase..
291:503-510.
1999
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Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans..
291:213-219.
1999
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Effects of sex and gonadectomy on cocaine metabolism in the rat..
290:1316-1323.
1999
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles..
290:551-560.
1999
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Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells..
289:1465-1471.
1999
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Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats..
289:334-345.
1999
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Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol..
287:1015-1019.
1998
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Nicotine evokes cell death in embryonic rat brain during neurulation..
287:1136-1144.
1998
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Fetal nicotine or cocaine exposure: which one is worse?.
285:931-945.
1998
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Dehydroepiandrosterone and analogs inhibit DNA binding of AP-1 and airway smooth muscle proliferation..
285:876-883.
1998
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The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line..
283:207-215.
1997
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Disposition of vessel dilator and long-acting natriuretic peptide in healthy humans after a one-hour infusion..
282:603-608.
1997
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Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes..
282:1072-1083.
1997
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Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations..
282:945-954.
1997
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Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters..
282:385-390.
1997
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Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung..
282:208-219.
1997
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Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats..
281:1350-1356.
1997
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Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro..
281:400-411.
1997
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Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase..
279:478-491.
1996
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Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly..
278:1050-1057.
1996
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Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum..
278:338-346.
1996
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Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype..
278:136-144.
1996
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Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter..
277:1437-1443.
1996
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Cocaine sensitization in periadolescent and adult rats..
275:345-357.
1995
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Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators..
274:1338-1347.
1995
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Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling..
273:1353-1360.
1995
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The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies..
273:1361-1374.
1995
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Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression..
273:415-426.
1995
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Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues..
272:134-142.
1995
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Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes..
271:1228-1233.
1994
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Role of thyroid status in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase, ornithine decarboxylase and c-fos protooncogene expression..
271:472-483.
1994
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beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions..
269:1292-1299.
1994
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Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function..
269:743-749.
1994
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Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices..
264:648-653.
1993
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Characterization of glomerular thromboxane receptors in murine lupus nephritis..
264:584-590.
1993
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NPC 15669 inhibits the reversed passive Arthus reaction in rats by blocking neutrophil recruitment..
263:933-937.
1992
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Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors..
263:413-421.
1992
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Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: effects of propylthiouracil-induced perinatal hypothyroidism..
261:951-958.
1992
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Developmental shift from local to central control of norepinephrine release in the cardiac-sympathetic axis: effects of cocaine and related drugs..
259:976-981.
1991
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Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil..
257:214-218.
1991
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Role of thyroid hormone in the development of beta adrenergic control of ornithine decarboxylase in rat heart and kidney..
256:757-766.
1991
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Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation..
256:204-210.
1991
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Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse..
256:289-296.
1991
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Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat..
255:1287-1295.
1990
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Effects of amiloride on pH regulation in canine cardiac Purkinje fibers..
254:83-90.
1990
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Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy..
253:1272-1277.
1990
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State dependence of ethacizin and ethmozin block of sodium current in voltage clamped and internally perfused cardiac Purkinje cells..
253:1110-1117.
1990
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Opioid-induced epileptiform bursting in hippocampal slices: higher susceptibility in ventral than dorsal hippocampus..
253:545-551.
1990
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Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake..
252:997-1005.
1990
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Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate..
252:817-825.
1990
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Cocaine-mediated impairment of cardiac conduction in the dog: a potential mechanism for sudden death after cocaine..
252:185-191.
1990
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Prenatal exposure to propranolol via continuous maternal infusion: effects on physiological and biochemical processes mediated by beta adrenergic receptors in fetal and neonatal rat lung..
252:42-50.
1990
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Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain..
251:894-900.
1989
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Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum..
250:117-125.
1989
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Phosphatidic acid phosphatase in neonatal rat lung: effects of prenatal dexamethasone or terbutaline treatment on basal activity and on responsiveness to beta adrenergic stimulation..
250:236-240.
1989
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Baclofen has a proepileptic effect in the rat dentate gyrus..
249:721-725.
1989
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Neonatal central catecholaminergic lesions with intracisternal 6-hydroxydopamine: effects on development of presynaptic and postsynaptic components of peripheral sympathetic pathways and on the ornithine decarboxylase/polyamine system in heart, lung and kidney..
247:975-982.
1988
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Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics..
247:439-444.
1988
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Role of sympathetic neurons in biochemical and functional development of the kidney: neonatal sympathectomy with 6-hydroxydopamine..
246:427-433.
1988
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Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling..
244:1150-1156.
1988
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Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel..
244:963-970.
1988
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Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems..
244:940-944.
1988
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Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins..
244:166-172.
1988
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Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide..
243:840-851.
1987
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Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development..
243:101-109.
1987
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Development of [3H]nicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions..
242:232-237.
1987
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Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development..
241:891-898.
1987
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Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol..
241:751-754.
1987
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Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion..
240:825-830.
1987
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Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat..
240:831-836.
1987
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Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps..
240:602-611.
1987
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Polyethylene glycol-stimulated microsomal GTP hydrolysis. Relationship to GTP-mediated Ca2+
release.
240:243-248.
1987
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Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome..
239:612-617.
1986
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Development of adrenergic and nonadrenergic pressor mechanisms in rats sympathectomized from birth..
238:1014-1020.
1986
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pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium..
238:159-166.
1986
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Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission..
237:881-887.
1986
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Catecholaminergic regulation of opiate-stimulated growth hormone secretion in the developing rat..
237:137-142.
1986
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Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists..
235:361-367.
1985
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Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons..
234:821-829.
1985
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Effect of chronic methadone administration on neuroendocrine function in young adult rats..
234:204-210.
1985
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Beta-2 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat..
233:141-147.
1985
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Type II cell response to chronic beta adrenergic agonist and antagonist infusions..
233:271-276.
1985
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Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding..
232:127-133.
1985
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Suppression of repetitive firing of neurons by diphenylbarbituric acid..
232:228-231.
1985
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Obligatory role of thyroid hormones in development of peripheral sympathetic and central nervous system catecholaminergic neurons: effects of propylthiouracil-induced hypothyroidism on transmitter levels, turnover and release..
230:53-61.
1984
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Amrinone in severe congestive heart failure: another look at an intriguing new cardioactive drug..
228:319-326.
1984
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Ontogeny of rat hepatic adrenoceptors..
227:181-186.
1983
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Paradoxical elevation of sympathetic activity during catecholamine infusion in rats..
227:254-259.
1983
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Inhibitory effects of anthracenedione antineoplastic agents on hepatic and cardiac lipid peroxidation..
226:500-506.
1983
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Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA)..
226:147-150.
1983
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Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain..
225:515-521.
1983
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Selective loss of ornithine decarboxylase response to adrenergic agonists and glucagon during food deprivation of neonatal rats..
225:50-56.
1983
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Maturation of sympathetic neurotransmission in the rat heart. IX. Development of transsynaptic regulation of cardiac adrenergic sensitivity..
223:675-680.
1982
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Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice..
223:291-297.
1982
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Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase..
222:746-751.
1982
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Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus..
222:670-673.
1982
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Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase..
222:741-745.
1982
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Development of polyamine and biogenic amine systems in brains and hearts of neonatal rats given dexamethasone: role of biochemical alterations in cellular maturation for producing deficits in ontogeny of neurotransmitter levels, uptake, storage and turnover..
221:686-693.
1982
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Maturation of sympathetic neurotransmission in the rat heart. VIII. Slowed development of noradrenergic synapses resulting from hypothyroidism..
220:629-636.
1982
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Maturation of sympathetic neurotransmission in the rat heart. IX. Development of transsynaptic regulation of cardiac adrenergic sensitivity.
233:675-680.
1982
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Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens..
219:290-295.
1981
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Diphenylhydantoin enhances early adaptation in Aplysia giant neurons..
218:41-45.
1981
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The neuromuscular blocking effects of therapeutic concentrations of various antibiotics on normal rat skeletal muscle: a quantitative comparison..
217:369-378.
1981
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Barbiturate enhancement of spike frequency adaptation in Aplysia giant neurons..
217:222-227.
1981
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Maturation of central nervous system control of growth hormone secretion in rats..
217:152-156.
1981
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Pharmacological studies of a novel dopamine-sensitive receptor mediating burst-firing inhibition of neurosecretory cell R 15 in Aplysia californica..
216:368-377.
1981
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Maturation of sympathetic neurotransmission in the rat heart. VII. Suppression of sympathetic responses by dexamethasone..
216:6-11.
1981
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Maturation of sympathetic neurotransmission in the rat heart. V. Development of baroreceptor control of sympathetic tone..
215:596-600.
1980
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Maturation of sympathetic neurotransmission in the rat heart. VI. The effect of neonatal central catecholaminergic lesions..
215:342-347.
1980
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Dopamine inhibits burst-firing of neurosecretory cell R 15 in Aplysia californica: establishment of a dose-response relationship..
214:112-118.
1980
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Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia..
214:161-165.
1980
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Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide..
212:153-161.
1980
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Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles..
212:120-125.
1980
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Maturation of sympathetic neurotransmission in the rat heart. II. Enhanced development of presynaptic and postsynaptic components of noradrenergic synapses as a result of neonatal hyperthyroidism..
212:126-130.
1980
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Accelerated development of rat sympathetic neurotransmission caused by neonatal triiodothyronine administration..
208:485-490.
1979
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The selection and evaluation of new chelating agents for the treatment of iron overload..
208:12-18.
1979
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Beta adrenergic stimulation of protein carboxymethylation and amylase secretion in rat parotid gland..
207:419-424.
1978
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Metabolism of amphetamine after acute and chronic administration to the rat..
207:544-554.
1978
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Age-dependence of inhibition of rat brain synaptic vesicle [3H]norepinephrine uptake caused by administration of a single dose of reserpine: persistence of inhibition in adults but not in neonates..
206:652-660.
1978
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Contribution of supracollicular structures of the brain to the central depression of cardiovascular function by clonidine..
205:693-701.
1978
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Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium..
205:193-203.
1978
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Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats..
205:164-174.
1978
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[3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes..
204:606-614.
1978
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[3
H-Ddihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes.
204:606-614.
1978
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Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation..
202:510-518.
1977
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Central depression of carotid baroreceptor pressor response, arterial pressure and heart rate by 5-hydroxytryptophan: influence of supracollicular areas of the brain..
202:310-319.
1977
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Effects of maternal ethanol ingestion on amine uptake into synaptosomes of fetal and neonatal rat brain..
200:292-297.
1977
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Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats..
199:141-148.
1976
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An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine..
198:12-22.
1976
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Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction..
197:414-425.
1976
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Effects of prenatal reserpine administration on development of the rat adrenal medulla and central nervous system..
197:293-302.
1976
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Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase..
196:714-722.
1976
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The effects of quinidine and verapamil on electrically induced automaticity in the ventricular myocardium of guinea pig..
196:407-419.
1976
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An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine.
198:12-22.
1976
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The uptake of methyl mercury (203Hg) in different tissues related to its neurotoxic effects..
187:602-611.
1973
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Electrophysiology of methyl mercury poisoning..
186:579-592.
1973
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A model of harmine metabolism in the rat..
174:456-462.
1970
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Blood levels and urinary excretion of harmine and its metabolites in man and rats..
173:26-30.
1970
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Effects of hemicholinium (HC-3) on EEG activation and brain acetylcholine in the dog..
161:141-154.
1968
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Chlorothiazide-induced kaliuresis after adrenalectomy..
156:366-368.
1967
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SELECTIVE DEPRESSION OF ALPHA MOTONEURONS OF SMALL SIZE BY ETHER..
148:380-385.
1965
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Effects of ether and thiopental on spinal presynaptic terminals..
140:396-402.
1963
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The mechanism of the blockade of synaptic transmission in the mammalian spinal cord by diethyl ether and by thiopental..
140:19-30.
1963
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Sites of action of the autonomic effects of 1,4-dipyrrolidino-2-butyne, Tremorine..
135:62-70.
1962