Molecular Pharmacology

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  Publication Venue For

  • Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle..  90:35-41. 2016
  • Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase..  89:645-651. 2016
  • The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?.  75:490-501. 2009
  • Erratum: The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor (Molecular Pharmacology (2008) 74 (454-465)).  75:255-257. 2009
  • N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator..  73:977-986. 2008
  • Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function..  72:582-591. 2007
  • The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma..  70:2108-2115. 2006
  • S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells..  70:1435-1442. 2006
  • The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13..  70:1461-1468. 2006
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling..  69:1518-1526. 2006
  • Redox regulation of PTEN by S-nitrosothiols..  68:847-854. 2005
  • Erratum: TRPV1b, a functional human vanilloid receptor splice variant (Molecular Pharmacology (2004) 67 (1119-1127)).  67:1818. 2005
  • Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis..  67:1229-1236. 2005
  • TRPV1b, a functional human vanilloid receptor splice variant..  67:1119-1127. 2005
  • Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family..  66:1325-1331. 2004
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor..  66:209-219. 2004
  • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery..  66:106-112. 2004
  • Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice..  65:1526-1535. 2004
  • The type 1 angiotensin II receptor tail affects receptor targeting, internalization, and membrane fusion properties..  65:362-369. 2004
  • Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder..  64:196-198. 2003
  • Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization..  63:9-18. 2003
  • Discovery of novel targets of quinoline drugs in the human purine binding proteome..  62:1364-1372. 2002
  • Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits..  62:1119-1127. 2002
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity..  62:971-974. 2002
  • Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure..  61:749-758. 2002
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis..  61:569-577. 2002
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha..  60:559-567. 2001
  • Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity..  58:976-981. 2000
  • Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies..  58:852-858. 2000
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors..  57:642-649. 2000
  • Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells..  55:855-862. 1999
  • Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features..  55:339-347. 1999
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages..  52:421-429. 1997
  • Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor..  52:508-514. 1997
  • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression..  51:951-962. 1997
  • CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance..  51:931-943. 1997
  • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization..  51:800-808. 1997
  • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate..  51:177-184. 1997
  • The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels..  50:1643-1650. 1996
  • CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance..  50:1111-1117. 1996
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A..  50:506-511. 1996
  • A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter..  49:1033-1041. 1996
  • Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells..  49:1012-1020. 1996
  • Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors..  49:438-446. 1996
  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation..  48:230-237. 1995
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C..  48:173-177. 1995
  • N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways..  47:1119-1125. 1995
  • Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification..  46:221-226. 1994
  • High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains..  46:352-356. 1994
  • Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine..  46:51-57. 1994
  • Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes..  45:608-617. 1994
  • Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor..  45:390-394. 1994
  • Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology..  45:171-175. 1994
  • Cloning and characterization of the opossum kidney cell D1 dopamine receptor: expression of identical D1A and D1B dopamine receptor mRNAs in opossum kidney and brain..  44:918-925. 1993
  • Characterization of alpha 2-adrenergic receptor subtype-specific antibodies..  43:444-450. 1993
  • 8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells..  42:817-825. 1992
  • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter..  42:383-390. 1992
  • Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning..  42:1-5. 1992
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)?.  41:1124-1129. 1992
  • The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity..  40:619-626. 1991
  • Patterns of internal and external tetraethylammonium block in four homologous K+ channels..  40:299-307. 1991
  • 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors..  40:22-27. 1991
  • Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity..  39:625-628. 1991
  • cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes..  39:370-375. 1991
  • Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration..  39:192-198. 1991
  • Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization..  39:55-63. 1991
  • The α(1C)-adrenergic receptor: Characterization of signal transduction pathways and mammalian tissue heterogeneity.  40:619-626. 1991
  • Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification..  38:599-603. 1990
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding..  38:14-19. 1990
  • Differential expression of gamma-aminobutyric acidA receptor subunits..  37:652-657. 1990
  • Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart..  36:723-729. 1989
  • Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites..  36:641-646. 1989
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes..  36:273-279. 1989
  • Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe..  36:15-21. 1989
  • The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor..  35:553-558. 1989
  • N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis..  34:250-255. 1988
  • Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi..  34:37-41. 1988
  • Interaction of the antifolate antibiotic trimethoprim with phosphatidylcholine membranes: a 13C and 31P nuclear magnetic resonance study..  33:551-558. 1988
  • The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi..  33:441-448. 1988
  • Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl..  33:272-278. 1988
  • Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study..  33:163-169. 1988
  • Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors..  33:133-139. 1988
  • Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene..  32:340-347. 1987
  • Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking..  31:129-134. 1987
  • γ-Aminobutyric acid (GABA)- and barbiturate-mediated ³⁶ Cl-uptake in rat brain synaptoneurosomes: Evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.  30:419-426. 1986
  • gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel..  30:419-426. 1986
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells..  29:606-613. 1986
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure..  28:348-356. 1985
  • Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung..  28:237-245. 1985
  • Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label..  27:499-506. 1985
  • Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors..  26:187-195. 1984
  • Barbiturate effects on acetylcholine-activated channels in Aplysia neurons..  24:449-457. 1983
  • [3H]acetylcholine binding sites in brain. Effect of disulfide bond modification..  24:387-391. 1983
  • Growth inhibition and metallothionein induction in cadmium-resistant cells by essential and non-essential metals..  24:77-83. 1983
  • Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A. Evidence for discrete classes of insulin binding sites..  22:619-626. 1982
  • Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides..  22:298-303. 1982
  • Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists..  22:290-297. 1982
  • Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain..  22:56-62. 1982
  • Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis..  21:133-141. 1982
  • Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes..  21:5-16. 1982
  • Solubilization of a [3H]cimetidine binding site from rat brains. A clonidine-sensitive H-2 receptor subtype?.  20:240-243. 1981
  • Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands..  20:28-34. 1981
  • Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands..  19:509-512. 1981
  • Anomalous equilibrium binding properties of high-affinity racemic radioligands..  19:205-216. 1981
  • Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes..  19:146-152. 1981
  • Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats..  18:247-252. 1980
  • Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels..  18:112-116. 1980
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data..  17:14-23. 1980
  • Inhibition of fast axoplasmic transport by delayed neurotoxic organophosphorus esters: a possible mode of action..  17:56-60. 1980
  • Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors..  16:709-718. 1979
  • Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli..  16:504-512. 1979
  • Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets..  16:61-68. 1979
  • Interaction of halothane with lipid bilayers..  16:163-170. 1979
  • Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique..  16:1-9. 1979
  • Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization..  16:10-20. 1979
  • Structural characteristics for inhibition of [3H] norepinephrine uptake into rat brain synaptic vesicles by beta-carboline, indolealkylamine, phenethylamine and n-alkylamine derivatives..  15:607-619. 1979
  • Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations..  14:868-878. 1978
  • Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets..  14:540-548. 1978
  • A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy..  14:376-380. 1978
  • Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors..  14:370-375. 1978
  • Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations..  13:304-313. 1977
  • Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes..  13:291-303. 1977
  • Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines..  12:559-567. 1976
  • X-ray crystal structure and conformation of a spin-labeled acetylcholine, DL-4-[N,N-dimethyl-n-(ethan-2'-olacetate)amino]-2,2,6,6-tetramethylpiperidine-1-oxyliodide..  12:590-597. 1976
  • Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro..  12:409-419. 1976
  • Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies..  12:16-31. 1976
  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors..  10:450-456. 1974
  • Reserpine-like effects of harmine on isolated adrenal medullary vesicles..  9:748-755. 1973
  • Recovery of rat adrenal amine stores after insulin administration..  9:105-116. 1973
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles..  7:581-592. 1971
  • Compartmental analysis of amine storage in bovine adrenal medullary granules..  7:308-316. 1971