Genes & Development

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  Publication Venue For

  • Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.  29:817-831. 2015
  • Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions..  29:322-336. 2015
  • Nucleotide-induced asymmetry within ATPase activator ring drives σ54-RNAP interaction and ATP hydrolysis..  27:2500-2511. 2013
  • A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern..  27:2147-2163. 2013
  • RIP3: a molecular switch for necrosis and inflammation..  27:1640-1649. 2013
  • Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression.  27:378-389. 2013
  • Photoactivated phytochromes interact with HEMERA and promote its accumulation to establish photomorphogenesis in Arabidopsis..  26:1851-1863. 2012
  • Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity..  25:1426-1438. 2011
  • Evidence for and against regional differences in neural stem and progenitor cells of the CNS..  24:2233-2238. 2010
  • A kiss of death--proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection..  23:2449-2454. 2009
  • Erratum: N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma (Genes and Development (2009) 23 (157-170)).  23:535. 2009
  • Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.  23:2824-2838. 2009
  • Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish..  22:728-733. 2008
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation..  22:308-321. 2008
  • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo..  22:436-448. 2008
  • Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling..  22:106-120. 2008
  • beta-Catenin is a Nek2 substrate involved in centrosome separation..  22:91-105. 2008
  • Motif module map reveals enforcement of aging by continual NF-kappaB activity..  21:3244-3257. 2007
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells..  21:2880-2896. 2007
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a..  21:2300-2311. 2007
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates..  21:2172-2181. 2007
  • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication..  21:2288-2299. 2007
  • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis..  21:1714-1719. 2007
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells..  21:1050-1063. 2007
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53..  21:848-861. 2007
  • MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans..  20:3342-3346. 2006
  • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases..  20:2949-2954. 2006
  • Phosphorylation and functions of the RNA polymerase II CTD..  20:2922-2936. 2006
  • Sox2 is required for development of taste bud sensory cells..  20:2654-2659. 2006
  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells..  20:666-674. 2006
  • Jab1 is a specificity factor for E2F1-induced apoptosis..  20:613-623. 2006
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor..  19:3043-3054. 2005
  • Bacterial outer membrane vesicles and the host-pathogen interaction..  19:2645-2655. 2005
  • Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes..  19:891-896. 2005
  • Not just another hole in the wall: understanding intercellular protein trafficking..  19:189-195. 2005
  • Coordination of replication and transcription along a Drosophila chromosome..  18:3094-3105. 2004
  • A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription..  18:2941-2951. 2004
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1..  18:1527-1532. 2004
  • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport..  18:1630-1642. 2004
  • Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome..  18:1533-1538. 2004
  • The MTE, a new core promoter element for transcription by RNA polymerase II..  18:1606-1617. 2004
  • Molecular cross-talk among chromosome fragility syndromes..  18:1359-1370. 2004
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway..  18:1423-1438. 2004
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote..  18:1263-1271. 2004
  • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.  18:641-659. 2004
  • Erratum: NF-κB RelA opposes epidermal proliferation driven by TNFR1 and JNK (Genes and Development (2004) 18 (17-22)).  18:461. 2004
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation..  18:249-254. 2004
  • NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK..  18:17-22. 2004
  • The generation of antibody diversity through somatic hypermutation and class switch recombination..  18:1-11. 2004
  • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs..  17:3011-3016. 2003
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis..  17:2933-2949. 2003
  • Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains..  17:2552-2563. 2003
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart..  17:2362-2367. 2003
  • Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice..  17:1219-1224. 2003
  • Genomic instability and endoreduplication triggered by RAD17 deletion..  17:965-970. 2003
  • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad..  17:800-810. 2003
  • Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress..  17:516-528. 2003
  • Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha..  16:3046-3060. 2002
  • Distinct requirements for Ras oncogenesis in human versus mouse cells..  16:2045-2057. 2002
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis..  16:1433-1440. 2002
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage..  16:560-570. 2002
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis..  15:2470-2482. 2001
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish..  15:2483-2493. 2001
  • The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress..  15:2134-2145. 2001
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm..  15:1998-2009. 2001
  • Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation..  15:1833-1844. 2001
  • Using viral species specificity to define a critical protein/RNA interaction surface..  15:1194-1205. 2001
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage..  15:1067-1077. 2001
  • COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis..  15:1115-1127. 2001
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice..  15:652-657. 2001
  • Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans..  15:201-212. 2001
  • A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root..  14:2938-2943. 2000
  • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability..  14:2501-2514. 2000
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP..  14:272-277. 2000
  • The TOR signaling cascade regulates gene expression in response to nutrients..  13:3271-3279. 1999
  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF..  13:2400-2411. 1999
  • The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences..  13:1126-1139. 1999
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo..  13:424-436. 1999
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells..  13:449-461. 1999
  • Yeast Cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.  13:320-333. 1999
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system..  13:188-201. 1999
  • BMP4 is essential for lens induction in the mouse embryo..  12:3764-3775. 1998
  • Defective potassium currents in ataxia telangiectasia fibroblasts..  12:3686-3692. 1998
  • A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation..  12:3564-3578. 1998
  • A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein..  12:3276-3285. 1998
  • The complexity of p53 modulation: emerging patterns from divergent signals..  12:2973-2983. 1998
  • Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK..  12:2887-2898. 1998
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type..  12:2499-2509. 1998
  • Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1..  12:2587-2597. 1998
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase..  12:2120-2130. 1998
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1..  12:2131-2143. 1998
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway..  12:1415-1424. 1998
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation..  12:968-981. 1998
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor..  12:21-33. 1998
  • DNA damage induces phosphorylation of the amino terminus of p53..  11:3471-3481. 1997
  • Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP..  11:3206-3217. 1997
  • The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis..  11:2996-3006. 1997
  • The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila..  11:3020-3031. 1997
  • GATA4 transcription factor is required for ventral morphogenesis and heart tube formation..  11:1048-1060. 1997
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye..  11:1073-1082. 1997
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo..  11:926-940. 1997
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development..  11:786-798. 1997
  • cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system..  11:603-615. 1997
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing..  10:3116-3128. 1996
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation..  10:2478-2490. 1996
  • A widespread transposable element masks expression of a yeast copper transport gene..  10:1917-1929. 1996
  • Bone morphogenetic proteins: multifunctional regulators of vertebrate development..  10:1580-1594. 1996
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse..  10:1657-1669. 1996
  • Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs..  10:1422-1432. 1996
  • Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters..  10:711-724. 1996
  • Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription..  10:592-603. 1996
  • Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast..  10:279-288. 1996
  • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity..  9:2873-2887. 1995
  • Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity..  9:2569-2582. 1995
  • Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus..  9:2203-2213. 1995
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse..  9:2105-2116. 1995
  • Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA..  9:1400-1410. 1995
  • The dishevelled protein is modified by wingless signaling in Drosophila..  9:1087-1097. 1995
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis..  9:600-611. 1995
  • The SABRE gene is required for normal cell expansion in Arabidopsis..  9:330-340. 1995
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis..  8:2302-2312. 1994
  • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression..  8:1514-1525. 1994
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal..  8:118-130. 1994
  • Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1..  7:2308-2317. 1993
  • Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing..  7:2329-2344. 1993
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA)..  7:2172-2180. 1993
  • Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification..  7:1824-1835. 1993
  • A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins..  7:883-894. 1993
  • Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles..  7:204-215. 1993
  • Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function..  7:29-41. 1993
  • Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2..  6:2021-2034. 1992
  • The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence..  6:2077-2087. 1992
  • The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F..  6:177-185. 1992
  • Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase..  6:93-104. 1992
  • Characterization of cDNAs encoding the polypyrimidine tract-binding protein..  5:1224-1236. 1991
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes..  5:1200-1211. 1991
  • Effect of RNA secondary structure on polyadenylation site selection..  5:1277-1284. 1991
  • Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments..  5:1136-1148. 1991
  • Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action..  4:1014-1022. 1990
  • Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns..  3:1874-1886. 1989
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development..  3:1657-1668. 1989
  • Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells..  3:1647-1656. 1989
  • A compensatory base change in human U2 snRNA can suppress a branch site mutation..  3:1545-1552. 1989
  • Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements..  3:1534-1544. 1989
  • The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus..  3:1493-1506. 1989
  • The DNA-binding homeo domain of the Oct-2 protein..  3:739-745. 1989
  • DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation..  3:620-627. 1989
  • An ordered pathway of assembly of components required for polyadenylation site recognition and processing.  3:2180-2190. 1989
  • Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly..  2:1307-1317. 1988
  • Expression of homeo box genes during mouse development: a review..  2:773-782. 1988
  • Activation and repression of mammalian gene expression by the c-myc protein..  1:347-357. 1987