Free Radical Biology and Medicine
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Publication Venue For
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Redox and the circadian clock in plant immunity: A balancing act..
119:56-61.
2018
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Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation.
103:69-86.
2017
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Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.
90:1-11.
2016
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Coordinated MicroRNA Silencing of Nox4 NADPH Oxidase and Myocardin Regulates Smooth Muscle Cell Dedifferentiation in Vascular Disease.
87:S58-S58.
2015
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Redox-Dependent Interaction Between Protein Disulfide Isomerase and P47phox activates Nox1 NADPH Oxidase in Vascular Disease.
87:S54-S54.
2015
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A Comprehensive Study of the Catalase Activity of Different Classes of Experimental Therapeutics Commonly Used as Redox Modulators.
76:S85-S86.
2014
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Mitigation of Radiation-Mediated Suppression of Hippocampal Neurogenesis.
76:S97-S97.
2014
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Mn Porphyrin-Based SOD Mimic, MnTnHex-2-PyP5+ and Non-SOD Mimic, MnTBAP3- suppresed Rat Spinal Cord Ischemia/reperfusion Injury via NF-κB Pathways.
76:S95-S95.
2014
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Rational Design of New Cationic Mn Porphyrins and Evaluation of Their Therapeutic Potential.
76:S94-S94.
2014
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The Role of Ascorbate in Therapeutic Actions of Cationic Mn Porphyrin-Based SOD Mimics.
76:S94-S95.
2014
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Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury..
74:210-221.
2014
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Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin..
69:265-277.
2014
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Critical Oxidative Stress Causes Early Fetal Brain Injury Resulting in Cerebral Palsy.
65:S50-S50.
2013
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Inhibition of the Electron Transport Chain Via the Pro-Oxidative Activity of Manganese Porphyrin-Based SOD Mimetics Modulates Bioenergetics and Enhances the Response to Chemotherapy.
65:S25-S25.
2013
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Mechanistic Considerations of the Therapeutic Effects of Mn Porphyrins, Commonly Regarded as SOD Mimics, in Anticancer Therapy: Lessons from Brain and Lymphoma Studies.
65:S120-S121.
2013
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Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs.
65:S83-S83.
2013
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Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.
65:S132-S132.
2013
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ROS-Mediated UV-Induced Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin.
65:S20-S21.
2013
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Reactivity and Cytoprotective Capacity of the Synthetic Catalytic Antioxidants Mnporphyrins towards Peroxynitrite and Hypochlorite.
65:S121-S122.
2013
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We Have Come a Long Way with Mn Porphyrins: from Superoxide Dismutation to H2O2-Driven Pathways.
65:S133-S133.
2013
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Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions..
53:1317-1326.
2012
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Response to "is flavohemoglobin a nitric oxide dioxygenase?".
53:1211-1212.
2012
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Mitochondrial Acetylomic Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice.
51:S19-S20.
2011
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Erratum: Inhibition of nitric oxide synthase by cobalamins and cobinamides (Free Radical Biology & Medicine (2009) 46 (1626-1632)).
51:1471.
2011
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Corrigendum to "Radio-protective effects of manganese-containing superoxide dismutase mimics on ataxia telangiectasia cells" [Free Radic. Biol. Med. 47/3 (2009) 250-260] (DOI:10.1016/j.freeradbiomed.2009.04.018).
47:1234.
2009
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Oxidative stress in diseases of the human cornea..
45:1047-1055.
2008
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Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice..
45:943-949.
2008
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Carbon monoxide, reactive oxygen signaling, and oxidative stress..
45:562-569.
2008
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Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier..
45:201-210.
2008
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The chemical biology of nitric oxide: implications in cellular signaling..
45:18-31.
2008
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Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection..
44:982-989.
2008
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Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide..
42:1704-1714.
2007
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Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion..
42:1571-1578.
2007
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Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia..
42:1338-1349.
2007
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Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria..
42:1193-1200.
2007
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Modification of cysteine 111 in human Cu,Zn-superoxide dismutase..
41:1837-1846.
2006
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Metabolic capacity regulates iron homeostasis in endothelial cells..
41:1662-1669.
2006
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Total nitrogen oxide following exercise testing reflects endothelial function and discriminates health status..
41:740-747.
2006
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Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite..
41:503-512.
2006
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Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition..
40:1332-1339.
2006
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Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme..
40:1419-1429.
2006
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Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes..
40:1220-1226.
2006
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Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal..
40:21-34.
2006
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Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice..
38:729-736.
2005
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Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading..
38:719-728.
2005
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Carbon monoxide actuates O(2)-limited heme degradation in the rat brain..
37:1802-1812.
2004
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Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity..
37:401-410.
2004
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S-Nitrosohemoglobin: an allosteric mediator of NO group function in mammalian vasculature..
37:442-453.
2004
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Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin..
37:367-374.
2004
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Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease..
36:1155-1162.
2004
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The iron cycle and oxidative stress in the lung..
36:850-857.
2004
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Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical..
36:340-347.
2004
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Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid..
35:1293-1300.
2003
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Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase..
35:845-855.
2003
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Redox regulation of neuronal migration in a Down Syndrome model..
35:566-575.
2003
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Pathways of cell signaling in hyperoxia..
35:341-350.
2003
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Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity..
34:937-946.
2003
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Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity..
33:1657-1669.
2002
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A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke..
33:1141-1152.
2002
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Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia..
33:947-961.
2002
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A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury..
33:857-863.
2002
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Apolipoprotein E isoform mediated regulation of nitric oxide release..
32:1071-1075.
2002
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The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression..
32:1116-1122.
2002
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Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure..
32:246-256.
2002
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AEOL 10150, a metalloporphyrin catalytic antioxidant, reduces injury from focal ischemia in the rat and mouse.
33:S126-S127.
2002
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Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/raumatic injuries of central nervous system..
33:S125-S126.
2002
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Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/traumatic injuries of central nervous system..
33:S236-S237.
2002
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Effects of metalloporphyrin catalytic antioxidant AEOL 10113 on radiation-induced lung injury.
33:S239-S239.
2002
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Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine..
31:175-180.
2001
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Activation of NO electrodes.
31:S76-S76.
2001
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Biliverdin is preorganized for dimeric metal complex formation, therefore for its antioxidant role in vitro.
31:S20-S20.
2001
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Changes in protein expression after a superoxide dismutase mimetic in stroke..
31:S132-S132.
2001
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Effects of metalloporphyrin catalytic antioxidants on rodent focal ischemic brain damage.
31:S134-S134.
2001
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Hepatic mitochondrial DNA damage and oxidative stress by lipopolysaccharide (LPS).
31:S90-S90.
2001
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Iron uptake in bronchial epithelial cells requires O2-transport by anion exchange protein 2.
31:S18-S18.
2001
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Mitochondrial DNA deletion decreases cytochrome oxidase subunit IV.
31:S84-S84.
2001
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Nitric oxide and peroxynitrite inhibits NADPH oxidase in human vascular smooth muscle cells..
31:S71-S71.
2001
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Nitric oxide in the respiratory cycle in human health and disease.
31:S71-S71.
2001
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Species-specific hemodynamic effects of metalloporphyrin SOD mimetics.
31:S96-S96.
2001
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Superoxide dismutase (SOD) mimetics in radiation therapy.
31:S128-S128.
2001
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The nitric oxide synthase inhibitor NG-nitro-L-arginine decreases defibrillation induced free radical generation.
31:S71-S71.
2001
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Manganese-porphyrin reactions with lipids and lipoproteins..
28:1017-1029.
2000
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Oxidative stress and adenine nucleotide control of mitochondrial permeability transition..
28:251-260.
2000
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Metalloporphyrins are potent inhibitors of lipid peroxidation..
26:730-736.
1999
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Porphyrin-based SOD mimics. Electrospray mass spectroscopy of Mn(III) and Fe(III) isomeric tetrakis-(N-alkylpyridyl) porphyrins..
27:S18-S18.
1999
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Thermodynamic linkage relationships in S-nitrosohemoglobin: Oxygen binding and vasoactivity.
27:S81-S81.
1999
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Nitration of membrane proteins in lungs after normoxic ischemia-reperfusion..
25:S61-S61.
1998
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Nitrosylation of blood hemoglobin and renal nonheme proteins in autoimmune MRL-lpr/lpr mice..
24:191-196.
1998
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Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat..
22:725-732.
1997
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Location-dependent artifact for no measurement using multiwell plates..
20:361-363.
1996
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Purification and characterization of the Cu,Zn SOD from Escherichia coli..
21:117-121.
1996
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Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells..
18:963-976.
1995
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Hydroxyl radical production in the brain after CO hypoxia in rats..
18:603-609.
1995
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The action of hydrogen peroxide on paired pulse and long-term potentiation in the hippocampus..
7:3-8.
1989
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2021 SFRBM DISCOVERY AWARD LECTURE
2022
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Antioxidant and Pro-Oxidant Actions of Mn Porphyrin-Based Therapeutics
2022
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MnTnBuOE-2-PyP5+ Ascorbate in the Treatment of Ovarian Cancer
2020
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Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease
2019
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Alternative splicing of Nox4 regulates subcellular redox-dependent pathways in vascular smooth muscle cells
2018
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Application of resonance raman spectroscopy on manganese porphyrin detection and redox state in endothelial cells: implications on cytoprotection towards peroxynitrite
2018
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Manganese superoxide dismutase regulates mTORC2 mediated UVB-induced mitophagy
2018
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Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy
2018
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Mn- and Fe-porphyrin-based SOD mimics are powerful suppressors of itch in histamine-dependent and -independent mouse models
2018
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Beneficial impact of a manganese(III) porphyrin in cancer cell migration
2018
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ROS regulate developmental and pathological denervation in vivo
2018
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Resonance raman studies on manganese porphyrin detection and redox state in endothelial cells: implications for antioxidant cytoprotection
2018
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A Novel MnSOD Mimetic Targets Various Redox States to Selectively Treat Hematopoietic Malignancies via Control of AP-1 Signaling
2017
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Novel fluorinated Mn porphyrin as a powerful SOD mimic and catalyst for ascorbate-coupled anticancer therapy
2017
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Protection Of Neurocognitive Function During Cranial Irradiation Of Brain Tumors
2017
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Protection of rat prostate and erectile function from radiation-induced damage by novel Mn(III) N - substituted pyridylporphyrin and ascorbate
2017
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Application of Resonance Raman spectroscopy for the direct detection of manganese porphyrins and their redox state in endothelial cells
2017
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A Novel Redox Based Therapy Targets the Malignant Cellular Redox State
2016
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Catalysis of Sulfite Oxidation Adds to the Array of Biologically Relevant Reactions of Cationic Mn(III) Porphyrins, Widely Known as SOD-Mimics
2016
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Circulating EGF-Like Ligands in Obesity Increase Neointimal Formation through Upregulation of NADPH Oxidase 1
2016
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Manganese Porphyrin, MnTE-2-PyP5+, Enhances Chemotherapeutic Response in Hematological Malignancies
2016
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Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP5+/Ascorbate System
2016
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Redox-Active Mn Porphyrins, MnTE-2-PyP5+ and MnTnBuOE-2-PyP5+ But Not Redox-Inert MnTBAP3-Suppress Tumor Growth in an Environment Where H2O2 Is Produced
2016
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Resonance Raman Studies on Manganese Porphyrin Detection and Redox State in Endothelial Cells
2016
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Redox Regulated Mitophagy in the Lung during Murine Sepsis
2013
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Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution
2012
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Nox1 NADPH Oxidase is Necessary for Late, but not Early, Ischemic Preconditioning against Myocardial Infarction in Mice
2012
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Nox1 Phosphorylation in Cardiovascular Disease
2012
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Quantification of Tetrahydrobiopterin (BH4), Dihydrobiopterin (BH2) and Biopterin (BP) in Mouse Brain and Intestines After Ischemic Injury by Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ESI-MS/MS)
2012
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Specific Residues in Peroxiredoxins Promote Peroxide Reactivity Through Effects on Cysteine pKa, Transition State Stabilization and Oligomerization
2012
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Understanding Differences in Mechanisms of Action of Fe vs Mn Porphyrins: Comparison of Their Reactivities Towards Cellular Reductants and Reactive Species
2012
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4-Hydroxy-2-Nonenal Mediates Aifm2 Release From Mitochondria: An Insight Into the Mechanism of Oxidative Stress Mediated Retrograde Signaling
2011
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A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties
2011
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Dual Antioxidant Activity of Boronate-Based Prochelators: Scavenging Peroxynitrite and Metal Ion Chelation
2011
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Experimental and Computational Studies on Mn Porphyrin-Based Therapeutics: Unforeseen Intramolecular Rearrangements on Methoxyalkyl Analogues of MnTE-2-PyP5+ and MnTnHex-2-PyP5+
2011
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Fe porphyrins Revisited: Synthesis, Characterization and the Effects of Ortho and Meta Fe(III) N-Alkylpyridylporphyrins Upon the Growth of E. Coli in the Presence and Absence of Ascorbate
2011
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Heme Oxygenase 1 Promotes Murine Stem Cell Differentiation into Beating Cardiomyocytes
2011
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Leptin is Key To Macrophage-Dependent Free Radical Formation in Ccl4-Induced Exacerbation of Steatohepatitis of Obesity
2011
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Lipophilic Mn Porphyrins in the Treatment of Brain Tumors
2011
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Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study
2011
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PGC-1α and the Mitochondrial Antioxidant Response during Sepsis
2011
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Timely Administration of Mn porphyrin, MnTM-2PyP5+ is Critical to Afford Protection in Diabetes: a Rat Study
2011
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Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins
2010
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Cationic Mn Porphyrins Change Their Action from anti- to pro-oxidative in the Presence of Cellular Reductants: Relevance to understanding the beneficial therapeutic effects of SOD mimics in vivo
2010
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Deconstructing Mitochondria: Co-localization of HO-1 and LC3II Mitophagy Protein in Liver Mitochondria during Oxidative Stress and Sepsis
2010
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Effect of Mn Porphyrins and Antioxidants on MRI Predictors and Behavior in an Animal Model of Cerebral Palsy
2010
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Increased Heme Degradation and Impaired Deformability of Red Blood Cells in Sickle Cell Disease and Anemia
2010
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Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells
2010
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Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies
2010
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The Beneficial Effects of One Year Pomegranate Juice Consumption on Traditional and Nontraditional Risk Factors for Cardiovascular Diseases
2010
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Thermal Stability of MnTE-2-PyPCl5, a Potent Catalytic Antioxidant and Cellular Redox Modulator
2010
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Understanding Protonation and Redox Equilibria of Metal site of Mn Porphyrin-based Cellular Redox Modulators is Essential for Comprehending their ROS-related Chemistry and Biology
2010
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Increased Lipophilicity of meta Mn(III) N-alkylpyridylporphyrins, when Compared to ortho isomers, Fully Compensates for their Lower SOD-like Activity when Protecting SOD-deficient E. coli
2009
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Lipophilicity of Potent Mn Porphyrin-based SOD and Peroxynitrite Reductase Mimics is Redox Modulated
2009
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Mitochondrial Biogenic Program in Human Skeletal Muscle Responds to Intermittent Low Level CO Breathing
2009
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The in vitro Cytotoxic Effects of Mn(III) Alkylpyridylporphyrin/ascorbate system on Four Tumor Cell Lines
2009
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Lipophilicity Is a Critical Parameter That Dominates the Efficacy of Metalloporphyrins in Blocking the Development of Morphine Antinociceptive Tolerance Through Peroxynitrite Mediated Pathways
2008
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Mntbap Selectively Scavenges Peroxynitrite Over Superoxide: Comparison of Mntbap to Mnte-2-Pyp in Two Different Models of Oxidative Stress Injuries, SOD-Specific E-coli Model and Carrageenan-Induced Pleurisy
2008
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Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator
2008
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Design and biodistribution of MN porphyrin-based therapeutics for oxidative stress
2007
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Erythropoietin promotes cardiac mitochondrial biogenesis through Akt activation
2007
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Heme oxygenase-1 supports mitochondrial function and protects against doxorubicin toxicity via the Pi3K/Akt pathway
2007
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Nitric oxide and toll-like receptor 4 are required for cardiac mitochondrial biogenesis after endotoxemia
2007
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Overproduction of beta-amyloid peptides induces chronic oxidative stress and suppresses MnSOD expression in mature neurons: implications for Alzheimer's disease
2007
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Pure MnTBAP is not a superoxide dismutase mimic in aqueous systems: A case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology
2007
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Recent advances in understanding structure-activity relationships of Mn porphyrin-based therapeutics: Charge distribution and electrostatic effects
2007
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Skeletal muscle mitochondrial biogenesis induced by carbon monoxide
2007
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Carbon monoxide protects against mitochondrial damage in doxorubicin-induced myocardial dysfunction
2006
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Extracellular superoxide regulates hypoxia-induced Egr-1 and tissue factor expression and promotes hypoxic pulmonary vascular remodeling
2006
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Metalloporphyrin mediated protection from renal ischemia/reperfusion injury
2006
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Metalloporphyrins mimic cyt P450 in activating cyclophosphamide in biologically relevant system
2006
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Mitochondrial biogenesis in sepsis: a role for inducible nitric oxide synthase
2006
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Mn porphyrin-based SOD mimic, MnTe-2-PyP5+ (AEOL-10113), targets mouse heart mitochondria after single 10 Mg/Kg IP administration
2006
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NOX4 mediates thrombin signaling in endothelial cells
2006
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Oxidation and CBS in neural derived cells
2006
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New Mn(III) porphyrins with high superoxide disproportionating ability
2005
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Transient carbon monoxide exposure induces cardiac mitochondriobiogenic response.
2005
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Ec-SOD overexpression reduces blood-spinal cord barrier permeability and inflammatory cell infiltration, but does not improve outcome from spinal cord compression injury in the mouse
2004
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Effects of 5-androsten-3fo-ol-17-one and related steroids on respiration in R3230 breast cancer cells; implications for PDT and IR
2004
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Improving bioavailibility of SOD mimics
2004
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MNTE-2-PYP5+ enhances tumor radiosensitivity by sensitizing tumor vasculature
2004
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PMNs exacerbate hyperoxic lung injury via augmented proinflammatory responses and alveolar epithelial cell injury
2004
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Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused, apolipoprotein E-deficient mice
2004
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Mn(III) meso tetrakis(N,N '-diethylimidazolium-2-yl)porphyrin (AEOL-10150) offers protection in mouse model of spinal cord injury
2003
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Recent advances in the synthesis and characterization of MN water-soluble porphyrin-based catalytic antioxidants
2003
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The role of antioxidant-1 in extracellular superoxide dismutase function
2003
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Mn(III) meso-tetrakis(ortho N-ethyl-pyridyl)porphyrin, MnTE-2-PyP (AEOL-10113) offers protection in mouse spinal cord injury model
2002
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Cupric-amyloid b peptide complexes stimulate oxidation of ascorbate and generation of OH- radials
2001
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The chemistry of nitroxyl (HNO) and implications in various therapeutic applications.
2001
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ecSOD overexpression in transgenic mice attenuates inflammation and lung injury following hyperoxia
1998