Bioorganic & Medicinal Chemistry Letters

Publication Venue For
- Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype.. 29:317-321. 2019
- Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series.. 28:3080-3084. 2018
- Synthetic efforts towards the stereoselective synthesis of NF00659B1.. 28:2746-2750. 2018
- Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.. 28:694-699. 2018
- The hydrolytic susceptibility of prochelator BSIH in aqueous solutions.. 27:4165-4170. 2017
- Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.. 27:2788-2792. 2017
- Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.. 26:1827-1830. 2016
- Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.. 26:68-71. 2016
- A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.. 25:4843-4847. 2015
- Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).. 25:4265-4269. 2015
- A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress. 25:4843-4847. 2015
- Evaluation of class i HDAC isoform selectivity of largazole analogues. 24:3728-3731. 2014
- Evaluation of class I HDAC isoform selectivity of largazole analogues.. 24:3728-3731. 2014
- Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.. 24:2585-2588. 2014
- Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.. 24:2206-2211. 2014
- Imidazole-derived agonists for the neurotensin 1 receptor. 24:262-267. 2014
- Fluorescence detection of cationic amyloid fibrils in human semen.. 23:5199-5202. 2013
- Synthesis and antifungal activities of miltefosine analogs.. 23:4828-4831. 2013
- Imidazole-derived agonists for the neurotensin 1 receptor 2013
- Synthesis and antifungal activities of miltefosine analogs. 23:4828-4831. 2013
- An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1.. 22:6521-6524. 2012
- 3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding. 22:6587-6590. 2012
- Blocking HIV-1 entry by a gp120 surface binding inhibitor. 22:3358-3361. 2012
- Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. 22:2772-2774. 2012
- Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors. 22:2376-2379. 2012
- Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. 22:7530-7533. 2012
- Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).. 21:7006-7012. 2011
- New betulinic acid derivatives as potent proteasome inhibitors.. 21:5944-5947. 2011
- Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.. 21:2832-2835. 2011
- The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.. 21:2836-2839. 2011
- Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.. 21:920-923. 2011
- A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. 21:4164-4169. 2011
- Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity. 21:5831-5834. 2011
- Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. 21:4945-4950. 2011
- Development of potent B-Raf ^V600E inhibitors containing an arylsulfonamide headgroup. 21:4436-4440. 2011
- Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.. 21:383-386. 2011
- Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid.. 20:4785-4788. 2010
- Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.. 20:4053-4056. 2010
- The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.. 20:887-892. 2010
- A single step purification for autolytic zinc proteinases.. 20:280-282. 2010
- Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.. 19:6122-6126. 2009
- Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.. 19:5482-5485. 2009
- Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.. 19:3288-3292. 2009
- Corrigendum to "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding" [Bioorg. Med. Chem. Lett. 19 (2009) 1694] (DOI:10.1016/j.bmcl.2009.01.094). 19:2604. 2009
- Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.. 19:2646-2649. 2009
- Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.. 19:1694-1697. 2009
- Discovery of thiophene inhibitors of polo-like kinase.. 19:1018-1021. 2009
- Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R). 19:1004-1008. 2009
- Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase. 19:469-473. 2009
- Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. 19:360-364. 2009
- Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine. 18:3778-3782. 2008
- Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.. 18:3200-3205. 2008
- Novel ORL1-selective antagonists with oral bioavailability and brain penetrability. 18:3282-3285. 2008
- Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.. 18:3047-3051. 2008
- Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.. 18:2023-2027. 2008
- The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.. 18:923-928. 2008
- Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. 18:6214-6217. 2008
- Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.. 17:4938-4941. 2007
- Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.. 17:4284-4289. 2007
- Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.. 17:3458-3462. 2007
- Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.. 17:1025-1032. 2007
- Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors. 17:1233-1237. 2007
- Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series.. 16:4686-4691. 2006
- Synthesis of Hsp90 dimerization modulators.. 16:3529-3532. 2006
- Identification of a potent and selective non-basic cathepsin K inhibitor.. 16:1985-1989. 2006
- Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.. 16:821-824. 2006
- Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.. 14:2319-2322. 2004
- Structure–activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines. 14:1503-1507. 2004
- Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.. 14:1043-1048. 2004
- 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.. 13:1195-1198. 2003
- Pyridazinones as selective cyclooxygenase-2 inhibitors.. 13:597-600. 2003
- Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines. 12:3161-3165. 2002
- Antitumor agents. Part 215: Antitubulin effects of cytotoxic B-ring modified allocolchicinoids. 12:2851-2853. 2002
- Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.. 12:823-825. 2002
- New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.. 12:209-212. 2002
- Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate.. 11:615-617. 2001
- Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.. 11:425-427. 2001
- Synthesis of P¹ -Citronellyl-P² -α-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG. 11:3107-3110. 2001
- Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).. 10:2683-2686. 2000
- A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.. 9:3181-3186. 1999
- Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.. 9:3187-3192. 1999
- Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.. 9:2963-2968. 1999
- Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.. 9:2391-2396. 1999
- The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.. 9:1773-1778. 1999
- Synthesis and biological activity of a novel series of indole-derived PPARγ agonists. 9:3329-3334. 1999
- A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles. 7:57-62. 1997
- Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. 7:47-52. 1997
- (-)-SCH 57939: Synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor. 6:2069-2072. 1996
- Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors. 6:1947-1950. 1996
- Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne. 6:1971-1976. 1996
- Substituted morpholine-2S-acetic acid derivatives: Sch 50911 and related compounds as novel GABAB antagonists. 6:1529-1534. 1996
- Direct characterization of solid phase resin-bound molecules by mass spectrometry. 6:979-982. 1996
- A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli. 6:909-912. 1996
- Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras. 6:195-200. 1996
- Justicidin E: A new leukotriene biosynthesis inhibitor.. 3:2063-2066. 1993
- Novel, stereoselective syntheses of penem antibiotics: efficient, formal syntheses of SCH 34343. 3:2171-2176. 1993
- Synthesis and absolute configuration of hydroxythreonine, a biosynthetic precursor of rhizobitoxine in pseudomonas. 3:2095-2098. 1993
- New hexahydroxydiphenyl derivatives as potent inhibitors of HIV replication in H9 lymphocytes. 2:235-238. 1992
- A new class of leukotriene biosynthesis inhibitors: The development of ((4-(4-chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636. 1:645-648. 1991
- 3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents. 4:593-598.
- Dicarboxylic acid inhibitors of phospholipase A2. 7:793-798.
- Synthesis and creatine kinase inhibitory activity of nonhydrolyzable analogs of phosphocreatine. 7:1021-1026.

Publication Venue For