Bioorganic & Medicinal Chemistry Letters
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Publication Venue For
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Synthetic efforts towards the stereoselective synthesis of NF00659B1
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28:2746-2750.
2018
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The hydrolytic susceptibility of prochelator BSIH in aqueous solutions..
27:4165-4170.
2017
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A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress..
25:4843-4847.
2015
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Evaluation of class I HDAC isoform selectivity of largazole analogues..
24:3728-3731.
2014
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Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening..
24:2585-2588.
2014
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An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1..
22:6521-6524.
2012
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Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants..
22:5190-5194.
2012
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New betulinic acid derivatives as potent proteasome inhibitors..
21:5944-5947.
2011
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A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold..
21:4164-4169.
2011
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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists..
21:2832-2835.
2011
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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14..
21:2836-2839.
2011
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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K..
21:920-923.
2011
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor..
20:887-892.
2010
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A single step purification for autolytic zinc proteinases..
20:280-282.
2010
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Corrigendum to "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding" [Bioorg. Med. Chem. Lett. 19 (2009) 1694] (DOI:10.1016/j.bmcl.2009.01.094).
19:2604.
2009
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Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.
18:3778-3782.
2008
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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor..
18:3200-3205.
2008
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Novel ORL1-selective antagonists with oral bioavailability and brain penetrability.
18:3282-3285.
2008
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Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B..
18:3047-3051.
2008
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Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein..
18:2023-2027.
2008
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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K..
18:923-928.
2008
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Bivalent peptides as PDZ domain ligands..
17:6147-6150.
2007
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Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1..
17:4938-4941.
2007
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Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging..
17:3458-3462.
2007
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Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase..
17:1025-1032.
2007
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Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series..
16:4686-4691.
2006
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Synthesis of Hsp90 dimerization modulators..
16:3529-3532.
2006
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Identification of a potent and selective non-basic cathepsin K inhibitor..
16:1985-1989.
2006
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Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma..
16:821-824.
2006
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Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative..
15:3849-3852.
2005
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme..
14:2319-2322.
2004
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Structure–activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.
14:1503-1507.
2004
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Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain..
14:1385-1388.
2004
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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors..
14:1043-1048.
2004
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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility..
13:1195-1198.
2003
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Pyridazinones as selective cyclooxygenase-2 inhibitors..
13:597-600.
2003
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Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines..
12:3161-3165.
2002
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Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids..
12:2851-2853.
2002
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Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues..
12:823-825.
2002
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New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties..
12:209-212.
2002
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Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG..
11:3107-3110.
2001
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Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate..
11:615-617.
2001
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Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1..
11:425-427.
2001
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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx)..
10:2683-2686.
2000
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Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists..
9:3329-3334.
1999
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A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors..
9:3181-3186.
1999
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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors..
9:3187-3192.
1999
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Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor..
9:2963-2968.
1999
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Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors..
9:2391-2396.
1999
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor..
9:1773-1778.
1999
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Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones..
8:2763-2768.
1998
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Synthesis and creatine kinase inhibitory activity of nonhydrolyzable analogs of phosphocreatine.
7:1021-1026.
1997
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A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles.
7:57-62.
1997
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Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors.
7:47-52.
1997
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(-)-SCH 57939: Synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor.
6:2069-2072.
1996
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Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors.
6:1947-1950.
1996
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Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne.
6:1971-1976.
1996
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Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA(B) antagonists.
6:1529-1534.
1996
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Direct characterization of solid phase resin-bound molecules by mass spectrometry.
6:979-982.
1996
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A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli.
6:909-912.
1996
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Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras.
6:195-200.
1996
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3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents.
4:593-598.
1994
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Justicidin E: A new leukotriene biosynthesis inhibitor..
3:2063-2066.
1993
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Novel, stereoselective syntheses of penem antibiotics: efficient, formal syntheses of SCH 34343.
3:2171-2176.
1993
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Synthesis and absolute configuration of hydroxythreonine, a biosynthetic precursor of rhizobitoxine in pseudomonas.
3:2095-2098.
1993
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New hexahydroxydiphenyl derivatives as potent inhibitors of HIV replication in H9 lymphocytes.
2:235-238.
1992
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A new class of leukotriene biosynthesis inhibitors: The development of ((4-(4-chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636.
1:645-648.
1991