Neurobiology of Disease

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  Publication Venue For

  • Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice..  124:152-162. 2019
  • TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities..  122:83-93. 2019
  • Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging..  119:79-87. 2018
  • Novel E815K knock-in mouse model of alternating hemiplegia of childhood..  119:100-112. 2018
  • Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model..  110:12-19. 2018
  • Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease..  109:249-257. 2018
  • The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin..  109:127-136. 2018
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration..  105:84-98. 2017
  • Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models..  93:137-145. 2016
  • A functional correlate of severity in alternating hemiplegia of childhood..  77:88-93. 2015
  • Differential roles of Aβ processing in hypoxia-induced axonal damage..  77:94-105. 2015
  • Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro..  75:1-14. 2015
  • Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits..  74:66-75. 2015
  • Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease..  70:214-223. 2014
  • Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner..  64:150-162. 2014
  • Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells..  62:160-171. 2014
  • LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction..  62:381-386. 2014
  • Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia..  62:469-478. 2014
  • Towards the study of functional brain development in depression: an Interactive Specialization approach..  52:38-48. 2013
  • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis..  49:107-117. 2013
  • Limited regional cerebellar dysfunction induces focal dystonia in mice..  49:200-210. 2013
  • Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy..  47:331-337. 2012
  • Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain..  47:20-28. 2012
  • Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors..  46:59-68. 2012
  • Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy..  45:165-176. 2012
  • Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation..  45:177-187. 2012
  • Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay..  43:248-256. 2011
  • Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus..  41:577-584. 2011
  • Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease..  39:311-317. 2010
  • Transglutaminase 2 protects against ischemic stroke..  39:334-343. 2010
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits..  37:622-629. 2010
  • Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction..  37:130-140. 2010
  • Metabolomics tools for identifying biomarkers for neuropsychiatric diseases..  35:165-176. 2009
  • Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus..  30:255-269. 2008
  • Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice..  28:76-82. 2007
  • Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease..  23:97-108. 2006
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture..  22:88-97. 2006
  • A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice..  21:505-514. 2006
  • Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease..  21:256-275. 2006
  • Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats..  21:165-180. 2006
  • Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress..  20:731-737. 2005
  • Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons..  19:77-83. 2005
  • Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta..  19:66-76. 2005
  • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology..  18:390-398. 2005
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42..  18:75-82. 2005
  • Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice..  12:56-64. 2003
  • Apolipoprotein E protects against NMDA excitotoxicity..  11:214-220. 2002
  • Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome..  10:306-326. 2002
  • Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion..  8:611-625. 2001
  • Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain..  8:1-10. 2001
  • Epilepsy..  7:549-551. 2000
  • Apolipoprotein E expression by neurons surviving excitotoxic stress..  6:508-514. 1999
  • Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons..  5:271-279. 1998
  • Apolipoprotein E uptake and low-density lipoprotein receptor-related protein expression by the NTera2/D1 cell line: a cell culture model of relevance for late-onset Alzheimer's disease..  4:58-67. 1997
  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice..  3:229-245. 1996