Sci Transl Med

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  Publication Venue For

  • Comparing antibody assays as correlates of protection against COVID-19 in the COVE mRNA-1273 vaccine efficacy trial..  15:eade9078. 2023
  • Rescue of glutaric aciduria type I in mice by liver-directed therapies..  15:eadf4086. 2023
  • Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later..  15:eadd6383. 2023
  • Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models..  15:eabn5649. 2023
  • CD200+ cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti-PD-1/PD-L1 therapy..  15:eabn5029. 2023
  • Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium..  14:eadd0484. 2022
  • Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation..  14:eabg8577. 2022
  • Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy..  14:eabq7019. 2022
  • Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment..  14:eabo3445. 2022
  • TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure..  14:eabm3565. 2022
  • Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection..  14:eabo5598. 2022
  • MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT..  14:eabj2829. 2022
  • Acute inflammatory response via neutrophil activation protects against the development of chronic pain..  14:eabj9954. 2022
  • A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk..  14:eabj9625. 2022
  • Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells..  14:eabc7480. 2022
  • Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b..  14:eabh3831. 2022
  • Translating science to medicine: The case for physician-scientists..  14:eabg7852. 2022
  • A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice..  14:eabj7125. 2022
  • A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus..  14:eabl7430. 2022
  • A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques..  13:eabg8116. 2021
  • Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis..  13:eabg8117. 2021
  • Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses..  13:eabi7428. 2021
  • Pregnancy influences immune responses to SARS-CoV-2..  13:eabm2070. 2021
  • The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia..  13. 2021
  • Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury..  13. 2021
  • Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR..  13. 2021
  • Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates..  13. 2021
  • Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1..  12. 2020
  • Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans..  12. 2020
  • Prospects for a safe COVID-19 vaccine..  12. 2020
  • Achieving healthy human longevity: A global grand challenge..  12. 2020
  • Global approaches to genomic medicine implementation..  12. 2020
  • An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs..  12. 2020
  • Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates..  12. 2020
  • APOE genotype regulates pathology and disease progression in synucleinopathy..  12. 2020
  • Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer..  11. 2019
  • Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation..  11. 2019
  • Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model..  11. 2019
  • Multiple roles for HIV broadly neutralizing antibodies..  11. 2019
  • Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa..  11. 2019
  • MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21..  11. 2019
  • A multimodality test to guide the management of patients with a pancreatic cyst..  11. 2019
  • Translational impact of NIH-funded nonhuman primate research in transplantation..  11. 2019
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease..  11. 2019
  • Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation..  11. 2019
  • Loss of HDAC3 results in nonreceptive endometrium and female infertility..  11. 2019
  • Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis..  10. 2018
  • Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7..  10. 2018
  • Health and societal implications of medical and technological advances..  10. 2018
  • In utero priming of highly functional effector T cell responses to human malaria..  10. 2018
  • Finding useful biomarkers for Parkinson's disease..  10. 2018
  • LRRK2 activation in idiopathic Parkinson's disease..  10. 2018
  • Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice..  10. 2018
  • Transcriptional signature primes human oral mucosa for rapid wound healing..  10. 2018
  • Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance..  10. 2018
  • Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice..  10. 2018
  • Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase..  9. 2017
  • Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia..  9. 2017
  • Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs..  9. 2017
  • When they go low, we go high..  9. 2017
  • Working memory: The real VIP..  9. 2017
  • The neural substrates of super memory..  9. 2017
  • Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors..  9. 2017
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide..  9. 2017
  • Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies..  9. 2017
  • Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2..  9. 2017
  • Suppressing oncogenic transcription with a little healthy competition..  9. 2017
  • Optimized temporal pattern of brain stimulation designed by computational evolution..  9. 2017
  • PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation..  8:369ra175. 2016
  • An EXITS strategy for decreasing cancer risk in women..  8:368ec197. 2016
  • Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition..  8:366ra164. 2016
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone..  8:340ra73. 2016
  • Treating the enigmatic "exceptional responders" as patients with undiagnosed diseases..  8:340ed8. 2016
  • Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages..  8:336ra62. 2016
  • Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology..  8:324ps5. 2016
  • A cybersecurity primer for translational research..  8:322ps2. 2016
  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival..  8:322ra10. 2016
  • Host gene expression classifiers diagnose acute respiratory illness etiology..  8:322ra11. 2016
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer..  8:320ra4. 2016
  • Pacemaker-induced transient asynchrony suppresses heart failure progression..  7:319ra207. 2015
  • Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker..  7:316ra193. 2015
  • Immune correlates of vaccine protection against HIV-1 acquisition..  7:310rv7. 2015
  • A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo..  7:302ra136. 2015
  • HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition..  7:296ra112. 2015
  • Global implementation of genomic medicine: We are not alone..  7:290ps13. 2015
  • Research in academic medical centers: two threats to sustainable support..  7:289fs22. 2015
  • The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors..  7:287ra72. 2015
  • Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy..  7:278ra34. 2015
  • Noninvasive brain-computer interface enables communication after brainstem stroke..  6:257re7. 2014
  • A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation..  6:256ra136. 2014
  • Reining in radiation injury: HIF2α in the gut..  6:236fs20. 2014
  • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination..  6:228ra39. 2014
  • Detection of circulating tumor DNA in early- and late-stage human malignancies..  6:224ra24. 2014
  • Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR..  5:212ra162. 2013
  • A brain-machine interface enables bimanual arm movements in monkeys..  5:210ra154. 2013
  • A host-based RT-PCR gene expression signature to identify acute respiratory viral infection..  5:203ra126. 2013
  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool..  5:197ra101. 2013
  • An integrated clinico-metabolomic model improves prediction of death in sepsis..  5:195ra95. 2013
  • CaMKII is essential for the proasthmatic effects of oxidation..  5:195ra97. 2013
  • Genomic medicine: a decade of successes, challenges, and opportunities..  5:189sr4. 2013
  • Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer..  5:181re1. 2013
  • Methylation subtypes and large-scale epigenetic alterations in gastric cancer..  4:156ra140. 2012
  • Thoroughly modern risk prediction?.  4:131fs10. 2012
  • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation..  4:124ra28. 2012
  • Preclinical and clinical evaluation of intraductally administered agents in early breast cancer..  3:106ra108. 2011
  • The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins..  3:106ra106. 2011
  • Academic medical centers: ripe for rapid-learning personalized health care..  3:101cm27. 2011
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis..  3:101ra93. 2011
  • Biomedical innovation: a risky business at risk..  3:96cm23. 2011
  • Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality..  3:94ra70. 2011
  • Defending male fertility..  3:92ps31. 2011
  • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development..  3:92ra66. 2011
  • Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys..  3:81ra36. 2011
  • Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss..  3:80re2. 2011
  • HIV-1 vaccines and adaptive trial designs..  3:79ps13. 2011
  • CD44-SLC1A2 gene fusions in gastric cancer..  3:77ra30. 2011
  • β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix..  3:74ra23. 2011
  • Pump-probe imaging differentiates melanoma from melanocytic nevi..  3:71ra15. 2011
  • Readily available tissue-engineered vascular grafts..  3:68ra9. 2011
  • Opening up to precompetitive collaboration..  2:52cm26. 2010
  • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease..  2:52ra73. 2010
  • Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability..  2:49ra68. 2010
  • Blood gene expression signatures predict invasive candidiasis..  2:21ra17. 2010
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation..  1:1ra1. 2009