Jci Insight
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Publication Venue For
- Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.. 7. 2022
- Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.. 7. 2022
- JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.. 7. 2022
- Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.. 7. 2022
- The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.. 7. 2022
- Cilia proteins are biomarkers of altered flow in the vasculature.. 7. 2022
- Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.. 7. 2022
- Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.. 7. 2022
- Increased Ca2+ influx through CaV1.2 drives aortic valve calcification.. 7. 2022
- Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis.. 7. 2022
- The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.. 6. 2021
- Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma.. 6. 2021
- Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents.. 6. 2021
- Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle.. 6. 2021
- Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.. 6. 2021
- Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.. 6. 2021
- Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.. 6. 2021
- Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation.. 6. 2021
- Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure.. 6. 2021
- Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.. 6. 2021
- MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.. 6. 2021
- Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration.. 5. 2020
- LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling.. 5:140627. 2020
- Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.. 5. 2020
- Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.. 5. 2020
- Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.. 5. 2020
- Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme.. 5. 2020
- Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.. 5. 2020
- CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation.. 5. 2020
- Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.. 5. 2020
- Robust antibody and cellular responses induced by DNA-only vaccination for HIV.. 5. 2020
- Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.. 5. 2020
- Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.. 5. 2020
- Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.. 5. 2020
- Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.. 5. 2020
- HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.. 5. 2020
- Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 5. 2020
- Interleukin-13 disrupts type 2 pneumocyte stem cell activity.. 5. 2020
- LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.. 5. 2020
- CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis.. 4. 2019
- L-Citrulline increases nitric oxide and improves control in obese asthmatics.. 4. 2019
- The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.. 4:128025. 2019
- Fetal exposure to the maternal microbiota in humans and mice.. 4. 2019
- Lowering circulating apolipoprotein E levels improves aged bone fracture healing.. 4. 2019
- Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.. 4. 2019
- Come sail away.. 4. 2019
- Glucagon lowers glycemia when β-cells are active.. 5. 2019
- Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.. 4. 2019
- RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.. 5. 2019
- Biomarkers of cavernous angioma with symptomatic hemorrhage.. 4. 2019
- Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.. 5. 2019
- Self-tolerance curtails the B cell repertoire to microbial epitopes.. 4. 2019
- Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.. 5. 2019
- WIPI1 is a conserved mediator of right ventricular failure.. 5. 2019
- Sleeve gastrectomy rapidly enhances islet function independently of body weight.. 4. 2019
- PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.. 4. 2019
- β Cell tone is defined by proglucagon peptides through cAMP signaling.. 4. 2019
- The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.. 4. 2019
- Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.. 4. 2019
- Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes.. 4. 2019
- A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.. 3. 2018
- Randomized trial of intravenous iron-induced hypophosphatemia.. 3. 2018
- AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.. 3:124297. 2018
- Injury promotes sarcoma development in a genetically and temporally restricted manner.. 3. 2018
- SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.. 3. 2018
- Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.. 3. 2018
- Neutrophil accumulation and NET release contribute to thrombosis in HIT.. 3. 2018
- Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.. 3. 2018
- Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction.. 3. 2018
- Wild-type Kras expands and exhausts hematopoietic stem cells.. 3. 2018
- Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.. 3. 2018
- Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.. 3. 2018
- Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site.. 3. 2018
- Physiological mechanisms of sustained fumagillin-induced weight loss.. 3. 2018
- The homozygous CX3CR1-M280 mutation impairs human monocyte survival.. 3. 2018
- Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.. 3. 2018
- DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.. 3. 2018
- We're listening.. 3. 2018
- Computational analysis of antibody dynamics identifies recent HIV-1 infection.. 2. 2017
- Intestinal, but not hepatic, ChREBP is required for fructose tolerance.. 2. 2017
- β-Arrestin2 mediates progression of murine primary myelofibrosis.. 2. 2017
- Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.. 2. 2017
- Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.. 2. 2017
- Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.. 2. 2017
- Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.. 2. 2017
- Wnt11 regulates cardiac chamber development and disease during perinatal maturation.. 2. 2017
- Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.. 2. 2017
- Rilonacept maintains long-term inflammatory remission in patients with deficiency of the IL-1 receptor antagonist.. 2. 2017
- Sustained immune tolerance induction in enzyme replacement therapy-treated CRIM-negative patients with infantile Pompe disease.. 2. 2017
- APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.. 2. 2017
- Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.. 2. 2017
- Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.. 2. 2017
- Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.. 2. 2017
- α-Synuclein in gut endocrine cells and its implications for Parkinson's disease.. 2. 2017
- T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response.. 2. 2017
- Resistance to hypertension mediated by intercalated cells of the collecting duct.. 2:e92720. 2017
- Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.. 2:e91782. 2017
- Mitochondrial quality-control dysregulation in conditional HO-1-/- mice.. 2:e89676. 2017
- A successful launch.. 2:e92800. 2017
- Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis.. 1:e89647. 2016
- Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.. 1:e88522. 2016
- Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.. 1:e89890. 2016
- Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.. 1:e88755. 2016
- Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain.. 1:e88034. 2016
- A cord blood monocyte-derived cell therapy product accelerates brain remyelination.. 1:e86667. 2016
- Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.. 1:e87001. 2016
- Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.. 1. 2016
- Durable and sustained immune tolerance to ERT in Pompe disease with entrenched immune responses.. 1. 2016
- Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors.. 1. 2016
- An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer.. 1. 2016
- Mitochondrial protein hyperacetylation in the failing heart.. 2. 2016
- Heme oxygenase-1 regulates mitochondrial quality control in the heart.. 1:e85817. 2016