Serine-Arginine Splicing Factors

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  Subject Areas on Research

  • A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding. 
  • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. 
  • Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. 
  • Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations. 
  • Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. 
  • Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. 
  • SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. 
  • U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. 
  • hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc.