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Subject Areas on Research
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A mouse model of juvenile hemochromatosis.
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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
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Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.
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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.
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Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice.
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Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.
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Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.
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Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.
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Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.
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Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.
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Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.
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Genes that modify the hemochromatosis phenotype in mice.
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HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study.
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Haptoglobin modifies the hemochromatosis phenotype in mice.
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Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
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Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
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Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
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Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.
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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
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Hereditary hemochromatosis: gene discovery and its implications for population-based screening.
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Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.
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Identification of Undetected Monogenic Cardiovascular Disorders.
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Identification of a novel mutation (C321X) in HJV.
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Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.
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Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C.
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Iron in skin of mice with three etiologies of systemic iron overload.
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Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity.
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Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.
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Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
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Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America.
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Regulation of iron absorption in Hfe mutant mice.
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Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
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Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis.
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Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
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The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.
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The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.
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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
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Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.