Huntingtin Protein
-
Subject Areas on Research
- Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
- Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.
- Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.
- Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.
- Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
- Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
- Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.
- Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
- Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.
- Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
- Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
- Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.
- In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.
- Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
- Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
- PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
- Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
- The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy.
- The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.