Huntingtin Protein
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Subject Areas on Research
- Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
- Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.
- Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
- Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
- Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.
- Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
- Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.
- Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
- Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.
- IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.
- In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.
- Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
- Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
- The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.