ADAMTS Proteins

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  Subject Areas on Research

  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. 
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. 
  • Disentangling the genetics of lean mass. 
  • Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival.