Beclin-1

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  Subject Areas on Research

  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. 
  • GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. 
  • Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians.