Autophagy-Related Protein 7

• 

  Subject Areas on Research

  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy is essential for mitochondrial clearance in mature T lymphocytes. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. 
  • GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. 
  • Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. 
  • The lung is protected from spontaneous inflammation by autophagy in myeloid cells. 
  • Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells.