APOBEC-3G Deaminase

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  Subject Areas on Research

  • A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor. 
  • Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors. 
  • Functional domain organization of human APOBEC3G. 
  • Further investigation of simian immunodeficiency virus Vif function in human cells. 
  • HIV-1 Vif: counteracting innate antiretroviral defenses. 
  • Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases. 
  • Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins. 
  • Selective inhibition of Alu retrotransposition by APOBEC3G. 
  • Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation. 
  • Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators. 
  • Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor. 
  • The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles. 
  • The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.