beta-Arrestin 1
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Subject Areas on Research
- A beta-arrestin 2 signaling complex mediates lithium action on behavior.
- A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
- A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
- Activation-dependent conformational changes in {beta}-arrestin 2.
- Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
- Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
- Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
- Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
- Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
- Beta-arrestin-mediated localization of smoothened to the primary cilium.
- Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.
- Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.
- DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
- Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
- Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.
- Enhanced morphine analgesia in mice lacking beta-arrestin 2.
- Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
- G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor.
- GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
- Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.
- Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
- Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
- Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
- LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.
- Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
- Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
- Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
- Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
- Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts.
- Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
- Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
- Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.
- Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
- Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
- The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.
- Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
- Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.
- Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.
- Visualization of arrestin recruitment by a G-protein-coupled receptor.
- beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
- beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
- beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
- beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
- beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
- beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
- {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
- β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.
- β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.
- β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.
- β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
- βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.