Protein Phosphatase 2C
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Subject Areas on Research
- A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.
- Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?
- Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
- Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
- Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.
- IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.
- Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.
- Metal dependent protein phosphatase PPM family in cardiac health and diseases.
- Nuclear phosphatase PPM1G in cellular survival and neural development.
- Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
- PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
- Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
- Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation.
- Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.
- Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
- Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma.
- TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
- Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
- The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
- The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation.
- Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm).
- p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.