Zinc Finger Protein GLI1
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Subject Areas on Research
- A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
- A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula.
- A small-molecule antagonist of the hedgehog signaling pathway.
- Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.
- Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
- Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.
- Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.
- Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
- Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice.
- Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.
- Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
- Hedgehog pathway and GLI1 isoforms in human cancer.
- Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
- Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer.
- Identification of Nedd4 as a novel regulator in Hedgehog signaling.
- Identification, functional characterization, and pathobiological significance of GLI1 isoforms in human cancers.
- Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
- Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.
- N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.
- Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
- Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
- Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.
- Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.
- Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells.
- Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.
- The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth.
- Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.