Glycogen Synthase Kinase 3 beta

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  Subject Areas on Research

  • A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1). 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Beta-catenin mediates soft tissue contracture in clubfoot. 
  • Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. 
  • Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. 
  • Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. 
  • Is lithium neuroprotective? An updated mechanistic illustrated review. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. 
  • Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. 
  • Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. 
  • Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. 
  • Signal integration and gene induction by a functionally distinct STAT3 phosphoform. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. 
  • Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.