Synthetic Lethal Mutations

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  Subject Areas on Research

  • Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. 
  • Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. 
  • Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. 
  • Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers. 
  • THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors. 
  • The "Inside" Story on Tumor-Expressed PD-L1. 
  • The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines. 
  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.