Smoothened Receptor
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Subject Areas on Research
- Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
- Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
- Beta-arrestin-mediated localization of smoothened to the primary cilium.
- Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.
- Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
- Glucocorticoid hedgehog agonists in neurogenesis.
- Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
- Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway.
- Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer.
- Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
- Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
- Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.
- Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.
- Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.
- Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.
- Patched-one or smoothened gene mutations are infrequent in chondrosarcoma.
- Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease.
- Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.
- Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.
- Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells.
- Smoothened is a master regulator of adult liver repair.
- Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
- Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
- Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins.
- Switching the Smoothened Inhibitor May Have Benefit in Advanced Basal Cell Carcinoma.
- Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.