Dynactin Complex

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  Subject Areas on Research

  • A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • KIF18B is a cell type-specific regulator of spindle orientation in the epidermis. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.