Bcl-2-Like Protein 11
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Subject Areas on Research
- A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
- A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies.
- A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer.
- Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).
- Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
- Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
- Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis.
- Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
- Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
- Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
- Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA.
- Expression level is a key determinant of E2F1-mediated cell fate.
- Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
- Heritable resistance to tyrosine kinase inhibitors.
- Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.
- Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.
- Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
- Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
- Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
- Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.
- The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.
- The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
- Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.
- c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.