Syk Kinase
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Subject Areas on Research
- 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
- A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.
- A phase Ib trial of mivavotinib (TAK-659), a dual SYK/FLT3 inhibitor, in patients with relapsed/refractory acute myeloid leukemia.
- Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.
- Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
- B cells in chronic graft-versus-host disease.
- BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.
- CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
- CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
- Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.
- Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
- Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function.
- Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions.
- Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
- Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway.
- Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
- NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.
- SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.
- Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
- Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer.
- Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.