Protein Domains

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  Subject Areas on Research

  • A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity. 
  • A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens. 
  • A Prion-based Thermosensor in Plants. 
  • A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS. 
  • A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. 
  • ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. 
  • Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities. 
  • Allosteric cooperation in a de novo-designed two-domain protein. 
  • Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. 
  • An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • Androgen Receptor Splice Variant, AR-V7, as a Biomarker of Resistance to Androgen Axis-Targeted Therapies in Advanced Prostate Cancer. 
  • BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. 
  • Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. 
  • Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice 
  • Cold sensitivity of the SARS-CoV-2 spike ectodomain. 
  • Controlling the SARS-CoV-2 spike glycoprotein conformation. 
  • Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. 
  • Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins. 
  • D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. 
  • Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. 
  • Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. 
  • Distinct Regions of the Haloferax volcanii Dolichol Phosphate-Mannose Synthase AglD Mediate the Assembly and Subsequent Processing of the Lipid-Linked Mannose. 
  • Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle. 
  • Domain prediction with probabilistic directional context. 
  • Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. 
  • Endosomal cAMP production broadly impacts the cellular phosphoproteome. 
  • Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases. 
  • Evolution of a σ-(c-di-GMP)-anti-σ switch. 
  • FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. 
  • FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans. 
  • Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants. 
  • Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. 
  • Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy. 
  • Germline AGO2 mutations impair RNA interference and human neurological development. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. 
  • Heat-dependent opening of TRPV1 in the presence of capsaicin. 
  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis. 
  • Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation. 
  • Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2. 
  • Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap. 
  • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. 
  • JMJD5 couples with CDK9 to release the paused RNA polymerase II. 
  • Localized force application reveals mechanically sensitive domains of Piezo1. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Mapping the interaction surface of scorpion β-toxins with an insect sodium channel. 
  • Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. 
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. 
  • Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction. 
  • Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice. 
  • PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. 
  • Pathogenic Bacteria Target Plant Plasmodesmata to Colonize and Invade Surrounding Tissues. 
  • Plant "helper" immune receptors are Ca²⁺ -permeable nonselective cation channels. 
  • Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers. 
  • Programmable mutually exclusive alternative splicing for generating RNA and protein diversity. 
  • Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains? 
  • Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. 
  • Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. 
  • Regulatory switch at the cytoplasmic interface controls TRPV channel gating. 
  • Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides. 
  • Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein. 
  • Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING. 
  • Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. 
  • Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. 
  • Structural basis of salicylic acid perception by Arabidopsis NPR proteins. 
  • Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structure of the cold- and menthol-sensing ion channel TRPM8. 
  • Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. 
  • Structures of human Patched and its complex with native palmitoylated sonic hedgehog. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection. 
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim. 
  • The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides. 
  • The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea. 
  • The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. 
  • The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. 
  • The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor. 
  • The membrane associated accessory protein is an adeno-associated viral egress factor. 
  • The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. 
  • The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. 
  • Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. 
  • Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase. 
  • Visualizing conformation transitions of the Lipid II flippase MurJ. 
  • Visualizing multistep elevator-like transitions of a nucleoside transporter. 
  • Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase. 
  • c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.