Protein Domains

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  Subject Areas on Research

  • A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens. 
  • A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS. 
  • Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis. 
  • Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities. 
  • Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. 
  • BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. 
  • COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. 
  • Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells. 
  • Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. 
  • Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway. 
  • Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue. 
  • Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. 
  • Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. 
  • Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins. 
  • Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. 
  • Domain prediction with probabilistic directional context. 
  • Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. 
  • Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases. 
  • FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans. 
  • Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants. 
  • Genetic and Molecular Basis of Kingella kingae Encapsulation. 
  • Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy. 
  • Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. 
  • Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa. 
  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis. 
  • Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation. 
  • Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2. 
  • Localized force application reveals mechanically sensitive domains of Piezo1. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics. 
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T. 
  • Programmable mutually exclusive alternative splicing for generating RNA and protein diversity. 
  • Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains? 
  • Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. 
  • Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. 
  • Regulatory switch at the cytoplasmic interface controls TRPV channel gating. 
  • Repeat-Specific Functions for the C-Terminal Domain of RNA Polymerase II in Budding Yeast. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides. 
  • Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein. 
  • Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING. 
  • Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. 
  • Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structure of the cold- and menthol-sensing ion channel TRPM8. 
  • Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. 
  • Structures of human Patched and its complex with native palmitoylated sonic hedgehog. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. 
  • The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. 
  • The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor. 
  • The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. 
  • The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. 
  • Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. 
  • Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase. 
  • Visualizing conformation transitions of the Lipid II flippase MurJ. 
  • Visualizing multistep elevator-like transitions of a nucleoside transporter. 
  • Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase. 
  • c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.