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Subject Areas on Research
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A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity.
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A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens.
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A Prion-based Thermosensor in Plants.
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A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS.
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A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
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ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.
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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.
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Allosteric cooperation in a de novo-designed two-domain protein.
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Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions.
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An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.
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An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.
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Androgen Receptor Splice Variant, AR-V7, as a Biomarker of Resistance to Androgen Axis-Targeted Therapies in Advanced Prostate Cancer.
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BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT.
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BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.
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Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.
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Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function.
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COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.
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Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.
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Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice
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Cold sensitivity of the SARS-CoV-2 spike ectodomain.
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Controlling the SARS-CoV-2 spike glycoprotein conformation.
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Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
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Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.
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D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
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Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
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Distinct Regions of the Haloferax volcanii Dolichol Phosphate-Mannose Synthase AglD Mediate the Assembly and Subsequent Processing of the Lipid-Linked Mannose.
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Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle.
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Domain prediction with probabilistic directional context.
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Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.
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Endosomal cAMP production broadly impacts the cellular phosphoproteome.
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Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.
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Evolution of a σ-(c-di-GMP)-anti-σ switch.
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FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.
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FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.
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Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants.
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Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.
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Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.
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Germline AGO2 mutations impair RNA interference and human neurological development.
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Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
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Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.
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Heat-dependent opening of TRPV1 in the presence of capsaicin.
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Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.
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Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation.
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Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.
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Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap.
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In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.
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JMJD5 couples with CDK9 to release the paused RNA polymerase II.
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Localized force application reveals mechanically sensitive domains of Piezo1.
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Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses.
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Mapping the interaction surface of scorpion β-toxins with an insect sodium channel.
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Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
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Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction.
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Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.
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Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.
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Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice.
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PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.
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Pathogenic Bacteria Target Plant Plasmodesmata to Colonize and Invade Surrounding Tissues.
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Plant "helper" immune receptors are Ca2+
-permeable nonselective cation channels.
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Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.
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Programmable mutually exclusive alternative splicing for generating RNA and protein diversity.
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Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
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Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis.
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Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.
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Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
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Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA.
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Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.
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Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.
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Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein.
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Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING.
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Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01.
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Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
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Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.
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Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
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Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.
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Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.
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Structure of the cold- and menthol-sensing ion channel TRPM8.
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Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
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Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
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Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ.
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Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection.
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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.
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The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure.
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The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.
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The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides.
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The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea.
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The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
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The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.
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The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.
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The membrane associated accessory protein is an adeno-associated viral egress factor.
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The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.
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The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
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Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
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Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase.
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Visualizing conformation transitions of the Lipid II flippase MurJ.
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Visualizing multistep elevator-like transitions of a nucleoside transporter.
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Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.
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c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.