CX3C Chemokine Receptor 1

• 

  Subject Areas on Research

  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients. 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Defective antitumor responses in CX3CR1-deficient mice. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. 
  • Microglia and memory: modulation by early-life infection. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. 
  • Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. 
  • Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. 
  • Resolving postoperative neuroinflammation and cognitive decline. 
  • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. 
  • The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis. 
  • The homozygous CX3CR1-M280 mutation impairs human monocyte survival. 
  • The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. 
  • Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation. 
  • Yolk-sac-derived macrophages progressively expand in the mouse kidney with age. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis.