DNA Polymerase gamma

• 

  Subject Areas on Research

  • Differential expression of mitochondrial DNA replication factors in mammalian tissues. 
  • Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. 
  • Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation. 
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 
  • Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like phenotype in a patient with a novel heterozygous POLG mutation.