TRPA1 Cation Channel

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  Subject Areas on Research

  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. 
  • Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. 
  • Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia. 
  • Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. 
  • H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • Inhibition of TRPA1 reduces airway inflammation and hyperresponsiveness in mice with allergic rhinitis. 
  • Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. 
  • Menthol preference among smokers: association with TRPA1 variants. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • OnabotulinumtoxinA effects on trigeminal nociceptors. 
  • Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • Pungent products from garlic activate the sensory ion channel TRPA1. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene. 
  • Sample preparation of the human TRPA1 ion channel for cryo-EM studies. 
  • Sensing hot and cold with TRP channels. 
  • Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • TRP channels in disease. 
  • TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation. 
  • TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. 
  • TRPA1 is a major oxidant sensor in murine airway sensory neurons. 
  • TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. 
  • TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. 
  • TRPA1: An asthma target with a zing. 
  • The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. 
  • The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. 
  • The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. 
  • Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Trigeminal TRPs and the scent of pain. 
  • Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1. 
  • miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus. 
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  Keywords of People

  • Jabba, Sairam V., Research Scientist, Anesthesiology