Proof of Concept Study

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  Subject Areas on Research

  • A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1). 
  • A Pilot Investigation of the Pediatric Nasal Microbiome. 
  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder. 
  • A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia. 
  • A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves. 
  • Ambulatory heart rate reduction after catheter-based renal denervation in hypertensive patients not receiving anti-hypertensive medications: data from SPYRAL HTN-OFF MED, a randomized, sham-controlled, proof-of-concept trial. 
  • An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment. 
  • Anterior gland focal cryoablation: proof-of-concept primary prostate cancer treatment in select men with localized anterior cancers detected by multi-parametric magnetic resonance imaging. 
  • Artificial intelligence automates and augments baseline impedance measurements from pH-impedance studies in gastroesophageal reflux disease. 
  • Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study. 
  • At-home hands-on surgical training during COVID19: proof of concept using a virtual telementoring platform. 
  • Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models. 
  • Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration. 
  • Creating a Practice-Based Implementation Network: Facilitating Practice Change Across Health Care Systems. 
  • Development and Preliminary Feasibility of iByte4Health: A Mobile Health (mHealth) Pediatric Obesity Prevention Intervention to Engage Parents with Low-Income of Children 2-9 Years. 
  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism. 
  • Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma. 
  • Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. 
  • Exploration of broadly neutralizing antibody fragments produced in bacteria for the control of HIV. 
  • Genetically Encoded Cholesterol-Modified Polypeptides. 
  • L-Citrulline increases nitric oxide and improves control in obese asthmatics. 
  • Machine learning derived segmentation of phase velocity encoded cardiovascular magnetic resonance for fully automated aortic flow quantification. 
  • MicroRNAs associated to single drug components of R-CHOP identifies diffuse large B-cell lymphoma patients with poor outcome and adds prognostic value to the international prognostic index. 
  • Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens. 
  • PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study. 
  • Peripheral serum metabolomic profiles inform central cognitive impairment. 
  • Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. 
  • Probabilities of Unranked and Ranked Anomaly Zones under Birth-Death Models. 
  • Programmable Site-Specific Functionalization of DNA Origami with Polynucleotide Brushes. 
  • Proof of concept study to develop a novel connectivity-based electric-field modelling approach for individualized targeting of transcranial magnetic stimulation treatment. 
  • Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer. 
  • Rationale and design for the study Apixaban versus ClopidoGRel on a background of aspirin in patient undergoing InfraPoPliteal angioplasty for critical limb ischemia: AGRIPPA trial. 
  • Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs. 
  • Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD. 
  • Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept. 
  • Subglottic Cryotherapy: A Pilot Study in New Zealand White Rabbits. 
  • The Effect of a Priest-Led Intervention on the Choice and Preference of Soda Beverages: A Cluster-Randomized Controlled Trial in Catholic Parishes. 
  • The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness. 
  • The left atrial appendage morphology is associated with embolic stroke subtypes using a simple classification system: A proof of concept study. 
  • Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.