Mechanistic Target of Rapamycin Complex 1
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Subject Areas on Research
- A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.
- A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer.
- A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
- AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
- ATM functions at the peroxisome to induce pexophagy in response to ROS.
- ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
- Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
- An expanded role of the tumor suppressor TSC1 in T cell tolerance.
- Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
- Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae.
- Cell-programmed nutrient partitioning in the tumour microenvironment.
- Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
- Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
- Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.
- DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation.
- Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
- Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
- Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
- Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.
- Everolimus tablets for patients with subependymal giant cell astrocytoma.
- FOXO protects against age-progressive axonal degeneration.
- Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice.
- Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
- Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.
- Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.
- Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.
- Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine.
- Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.
- MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.
- MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.
- Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
- Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
- Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
- Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.
- Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
- Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
- Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
- PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
- Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer.
- Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.
- Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations.
- Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
- Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
- Regulation of T-cell survival and mitochondrial homeostasis by TSC1.
- Regulation of mast cell survival and function by tuberous sclerosis complex 1.
- Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
- Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis.
- TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.
- TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
- Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.
- The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
- The role of tuberous sclerosis complex 1 in regulating innate immunity.
- Tumor suppressor TSC1 is critical for T-cell anergy.
- Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
- Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.
- iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
- mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
- mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
- mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.