CCCTC-Binding Factor
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Subject Areas on Research
- A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
- An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.
- Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.
- Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.
- Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.
- Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
- Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.
- Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
- Heritable individual-specific and allele-specific chromatin signatures in humans.
- Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
- Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
- Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC.
- Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.
- Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
- Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.
- Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids.
- Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
- Site-specific silencing of regulatory elements as a mechanism of X inactivation.
- Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
- Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.