Acetaminophen

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  Subject Areas on Research

  • A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. 
  • A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. 
  • Acetaminophen and hepatic dysfunction in infectious mononucleosis. 
  • Acetaminophen and liver disease. 
  • Acetaminophen and ondansetron: The central serotonergic connection. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1. 
  • Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. 
  • Administration of Oral Acetaminophen to Reduce Costs for the Hysterectomy Patient at a Community Hospital. 
  • Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061]. 
  • Analgesia After Cesarean Delivery in the United States 2008-2018: A Retrospective Cohort Study. 
  • Analgesia in the surgical intensive care unit. 
  • Analgesic drug use and risk of ovarian cancer. 
  • Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. 
  • Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation. 
  • Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery. 
  • Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. 
  • Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. 
  • Chronic salicylism resulting in noncardiogenic pulmonary edema requiring hemodialysis. 
  • Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury. 
  • Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. 
  • Comparative analysis of length of stay, hospitalization costs, opioid use, and discharge status among spine surgery patients with postoperative pain management including intravenous versus oral acetaminophen. 
  • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. 
  • Death of a living liver donor from illicit drugs. 
  • Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. 
  • Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. 
  • Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Effect of pain management on immunization efficacy in mice. 
  • Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. 
  • Effects of Acetaminophen, NSAIDs, Gabapentinoids, and Their Combinations on Postoperative Pulmonary Complications After Total Hip or Knee Arthroplasty. 
  • Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro. 
  • Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. 
  • Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats. 
  • Elevated metabolites of acetaminophen in cord blood of children with obesity. 
  • Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401]. 
  • Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. 
  • Evaluating the Implementation of a Preemptive, Multimodal Analgesia Protocol in a Plastic Surgery Office. 
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. 
  • Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation? 
  • Hepatic failure after rectal acetaminophen. 
  • Impact of a multimodal analgesic protocol modification on opioid consumption after cesarean delivery: a retrospective cohort study. 
  • In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. 
  • Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. 
  • Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure. 
  • Intravenous Acetaminophen Does Not Decrease Persistent Surgical Pain After Cardiac Surgery. 
  • Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial. 
  • Intravenous acetaminophen: Can the benefit outweigh the cost in selected patients? 
  • Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. 
  • Lack of effect of cimetidine on acetaminophen disposition in humans. 
  • Letter to the Editor on "Randomized Prospective Trial Comparing the Use of Intravenous Versus Oral Acetaminophen in Total Joint Arthroplasty". 
  • Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism? 
  • Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. 
  • Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. 
  • Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. 
  • Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. 
  • Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice. 
  • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. 
  • Multimodal Pain Management for Major Joint Replacement Surgery. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. 
  • Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. 
  • Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury. 
  • Oral Multimodal Analgesia for Total Joint Arthroplasty. 
  • Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen. 
  • Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. 
  • Painful acute radiation thyroiditis induced by 131I treatment of Graves' disease. 
  • Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. 
  • Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. 
  • Patient Satisfaction and Pain Control Using an Opioid-Sparing Postoperative Pathway. 
  • Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings. 
  • Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology. 
  • Preemptive Oral Acetaminophen for Women Undergoing Total Laparoscopic Hysterectomy. 
  • Randomized Population Pharmacokinetic Analysis and Safety of Intravenous Acetaminophen for Acute Postoperative Pain in Neonates and Infants. 
  • Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. 
  • Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. 
  • Reduction in Opioid Prescribing Through Evidence-Based Prescribing Guidelines. 
  • Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. 
  • Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity. 
  • Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps. 
  • Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. 
  • Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • Supratherapeutic dosing of acetaminophen among hospitalized patients. 
  • Systematic review: prognostic tests of paracetamol-induced acute liver failure. 
  • The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model 
  • The effect of antipyretics on immune response and fever following receipt of inactivated influenza vaccine in young children. 
  • The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. 
  • The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. 
  • The role of intravenous acetaminophen in multimodal pain protocols for perioperative orthopedic patients. 
  • The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. 
  • The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose. 
  • The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence. 
  • The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome? 
  • The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. 
  • Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats. 
  • Underutilization of Acetaminophen in Older Adult Trauma Patients. 
  • Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. 
  • Utilization of a Preemptive, Multimodal Analgesic Regimen in Adult Ambulatory Septoplasty Patients: A Quality Improvement Project. 
  • Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Shinohara, Mari L., Associate Professor of Immunology, Cell Biology