Acetaminophen

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  Subject Areas on Research

  • A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. 
  • A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. 
  • A validated HPLC method for the determination of pyridostigmine bromide, acetaminophen, acetylsalicylic acid and caffeine in rat plasma and urine. 
  • Acetaminophen and hepatic dysfunction in infectious mononucleosis. 
  • Acetaminophen and liver disease. 
  • Acetaminophen and ondansetron: The central serotonergic connection. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. 
  • Adult cancer pain. 
  • Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061]. 
  • Analgesia in the surgical intensive care unit. 
  • Analgesic drug use and risk of ovarian cancer. 
  • Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. 
  • Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation. 
  • Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury. 
  • Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. 
  • Comparative analysis of length of stay, hospitalization costs, opioid use, and discharge status among spine surgery patients with postoperative pain management including intravenous versus oral acetaminophen. 
  • Death of a living liver donor from illicit drugs. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Effect of pain management on immunization efficacy in mice. 
  • Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. 
  • Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro. 
  • Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. 
  • Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401]. 
  • Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. 
  • Evaluating the Implementation of a Preemptive, Multimodal Analgesia Protocol in a Plastic Surgery Office. 
  • Evaluation of a method to reduce over-the-counter medication dosing error. 
  • Evaluation of anti-pyretic potential of Ficus racemosa bark. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. 
  • Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial. 
  • Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. 
  • Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. 
  • Mathematical modeling of the effect of different intravenous acetylcysteine regimens on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose 
  • Mathematical modeling of the effect of late administration of a novel acetylcysteine regimen based on the SNAP trial on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose 
  • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. 
  • NCCN Practice Guidelines for Cancer Pain. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. 
  • Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. 
  • Nonsteroidal anti-inflammatory drugs and acetaminophen in the treatment of an acute muscle injury. 
  • Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen. 
  • Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. 
  • Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings. 
  • Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology. 
  • Postoperative pain management in preverbal children: the prescription and administration of analgesics with and without caudal analgesia. 
  • Quantitation of in vivo measurements with carbon fiber microelectrodes. 
  • S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. 
  • Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • Supratherapeutic dosing of acetaminophen among hospitalized patients. 
  • The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model. 
  • The effect of antipyretics on immune response and fever following receipt of inactivated influenza vaccine in young children. 
  • The effect of cyclooxygenase-2 inhibition on acute and chronic donor-site pain after spinal-fusion surgery. 
  • The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. 
  • The role of intravenous acetaminophen in multimodal pain protocols for perioperative orthopedic patients. 
  • The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. 
  • The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose. 
  • The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. 
  • Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. 
  • Utilization of a Preemptive, Multimodal Analgesic Regimen in Adult Ambulatory Septoplasty Patients: A Quality Improvement Project. 
  • Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology