Acetyl-CoA Carboxylase

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  Subject Areas on Research

  • A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. 
  • ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. 
  • Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. 
  • Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay. 
  • Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. 
  • Diet and sex modify exercise and cardiac adaptation in the mouse. 
  • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. 
  • Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. 
  • Intracellular mediators of insulin action. 
  • Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. 
  • Metabolic profiling of muscle contraction in lean compared with obese rodents. 
  • Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. 
  • Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins. 
  • Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction. 
  • Preclinical developments in type 2 diabetes. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice. 
  • TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading. 
  • The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis.