Acetylcholinesterase

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  Subject Areas on Research

  • Acetylcholinesterase inhibition and Gulf War illnesses: conclusions are not supported by independent reviews of the same evidence. 
  • Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships. 
  • Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. 
  • Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. 
  • Axoplasmic transport and turnaround of neurotoxic esterase in hen sciatic nerve. 
  • Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures. 
  • Brain acetylcholinesterase, acid phosphatase, and 2',3'-cyclic nucleotide-3'-phosphohydrolase and plasma butyrylcholinesterase activities in hens treated with a single dermal neurotoxic dose of S,S,S-tri-n-butyl phosphorotrithioate. 
  • Brain ligatin: a membrane lectin that binds acetylcholinesterase. 
  • Chemical and pharmacokinetic considerations in structure-activity relationships: panel discussion. 
  • Cholinergic innervation of choroid plexus in rabbits and cats. 
  • Clinical microbiological case: severe relapsing septal panniculitis in a healthy man from the south-eastern USA. 
  • Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. 
  • Comparative properties of channel catfish (Ictalurus punctatus) and blue crab (Callinectes sapidus) acetylcholinesterases. 
  • Delayed neurotoxicity of leptophos and related compounds: differential effects of subchronic oral administration of pure, technical grade and degradation products on the hen. 
  • Delayed neurotoxicity of leptophos: toxic effects on the nervous system of hens. 
  • Descending projections from the superior olivary complex to the cochlear nucleus of the cat. 
  • Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity. 
  • Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. 
  • Developmental aspects of the cholinergic system. 
  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. 
  • Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. 
  • Distribution of acetylcholinesterase in the geniculo striate system of Galago senegalensis and Aotus trivirgatus: evidence for the origin of the reaction product in the lateral geniculate body. 
  • Distributions of choline acetyltransferase and acetylcholinesterase activities in the retinal layers of pigeon red and yellow fields. 
  • Distributions of choline acetyltransferase and acetylcholinesterase activities in the retinal layers of the red-tailed hawk and road runner. 
  • Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. 
  • Effects of a dermal dose of S,S,S,-tri-n-butyl phosphorotrithioate on brain acetylcholinesterase, acid phosphatase, and 2',3'-cyclic nucleotide-3' phosphohydrolase and plasma butyrylcholinesterase in hens. 
  • Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping. 
  • Evidence for a striking increase in acetylcholinesterase activity in cultured human fibroblasts which are trisomic for chromosome two. 
  • Expression of airway contractile properties and acetylcholinesterase activity in swine. 
  • Fish brain cholinesterase: its inhibition by carbamates and automatic assay. 
  • Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. 
  • Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. 
  • Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. I. Time course after complete unilateral entorhinal lesion at various ages. 
  • Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions. 
  • Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype. 
  • Hydrolysis of phthalyl amino acid esters of fluoroscein in the presence of leucine aminopeptidase. 
  • Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. 
  • In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. 
  • Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. 
  • Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats. 
  • Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats. 
  • Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion. 
  • Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway. 
  • Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). 
  • Late acute, delayed neurotoxic and cholinergic effects of S,S,S-tributyl phosphorotrithioite (Merphos) in hens. 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Loss of hippocampal acetylcholinesterase staining after fornix lesion in the monkey. 
  • Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. 
  • Modulation of avian muscarinic cholinergic high affinity binding sites by a neurotoxic organophosphate. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. 
  • New concepts of ureterovesical innervation. 
  • Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. 
  • Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. 
  • Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. 
  • Organophosphorus ester-induced chronic neurotoxicity. 
  • Physiological mechanisms mediating enhanced force generation during development and immune sensitization. 
  • Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans. 
  • Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. 
  • Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor. 
  • Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. 
  • Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. 
  • Sarin: health effects, metabolism, and methods of analysis. 
  • Semi-automated 3D segmentation of major tracts in the rat brain: comparing DTI with standard histological methods. 
  • Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats. 
  • Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria. 
  • Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. 
  • Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. 
  • Target size of neurotoxic esterase and acetylcholinesterase as determined by radiation inactivation. 
  • The Inab phenotype: characterization of the membrane protein and complement regulatory defect. 
  • The acetylcholinesterase defect in paroxysmal nocturnal hemoglobinuria: evidence that the enzyme is absent from the cell membrane. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The effect of chlorothiazide on neurally mediated contraction of rabbit bronchial smooth muscle. 
  • The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. 
  • The laminar organisation of the lateral geniculate body in Galago senegalensis: a pair of layers identified by acetylcholinesterase activity. 
  • The neurohistochemistry of mammalian ureter: a new combination of histochemical procedures to demonstrate adrenergic, cholinergic and chromaffin structures in ureter. 
  • The ureterovesical innervation. A new concept based on a histochemical study. 
  • Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. 
  • Variation between three strains of rat: inhibition of neurotoxic esterase and acetylcholinesterase by tri-o-cresyl phosphate. 
  • [Histochemical studies on the medial regions of the brainstem in guinea pigs]. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.