Acidosis

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  Subject Areas on Research

  • A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation. 
  • Acid-base analysis of individuals following two weight loss diets. 
  • Acid-base status of seriously wounded combat casualties. II. Resuscitation with stored blood. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. 
  • Acidosis associated with dietotherapy of maple syrup urine disease. 
  • Age-specific associations of reduced estimated glomerular filtration rate with concurrent chronic kidney disease complications. 
  • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. 
  • Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease. 
  • Blood lactate: biochemistry, laboratory methods, and clinical interpretation. 
  • Brain oxygenation and energy metabolism: part I-biological function and pathophysiology. 
  • Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Dietary acid load: a novel nutritional target in chronic kidney disease? 
  • Disorders of acid-base relationships in the cerebrospinal fluid: a review. 
  • Distinguishing Arterial Ischemic Stroke From Hypoxic-Ischemic Encephalopathy in the Neonate at Birth. 
  • Effect of acidosis on glutamine transport by isolated rat renal brush-border and basolateral-membrane vesicles. 
  • Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. 
  • Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance. 
  • Encephalopathy of Reye's syndrome: a review of pathogenetic hypotheses. 
  • Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease. 
  • Ethylmalonic aciduria: an organic acidemia with CNS involvement and vasculopathy. 
  • Evaluating a critically ill patient with metabolic acidosis: the ifosfamide paradigm. 
  • Glutamine transport into isolated renal membrane vesicles from normal and acidotic rats. 
  • Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. 
  • Inflammatory hypoxia: role of hypoxia-inducible factor. 
  • Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. 
  • Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome. 
  • Insulin therapy for ketolactic acidosis complicating malignancy. 
  • Intraretinal pH in diabetic cats. 
  • Ischemic stroke: "acidotoxicity" is a perpetrator. 
  • Maternal insufflation during the second trimester equivalent produces hypercapnia, acidosis, and prolonged hypoxia in fetal sheep. 
  • Mitochondrial cytochrome deficiency presenting as a myopathy with hypotonia, external ophthalmoplegia, and lactic acidosis in an infant and as fatal hepatopathy in a second cousin. 
  • Not so good to the last drop. Ethylene glycol poisoning in a coffee-consuming camper. 
  • Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Relationship between phosphaluria and acute hypercapnia in the rat. 
  • Role of Acid-Base Homeostasis in Diabetic Kidney Disease. 
  • Serum electrolyte patterns in end-stage renal disease. 
  • Severity and Duration of Metabolic Acidosis After Deep Hypothermic Circulatory Arrest for Thoracic Aortic Surgery. 
  • Sodium bicarbonate use and the risk of hypernatremia in thoracic aortic surgical patients with metabolic acidosis following deep hypothermic circulatory arrest. 
  • The effect of systemic acidosis on perfusion of replanted extremities. 
  • The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. 
  • The genomic analysis of lactic acidosis and acidosis response in human cancers. 
  • The impact of tumor physiology on camptothecin-based drug development. 
  • The influence of supplemental sodium acetate on carbonic anhydrase inhibitor-induced side effects. 
  • The relationship between the tumor physiologic microenvironment and angiogenesis. 
  • The renal excretion of hydrogen ion in renal tubular acidosis. I. quantitative assessment of the response to ammonium chloride as an acid load. 
  • The role of repeat angiography in the management of pelvic fractures. 
  • Topiramate-induced confusion following a single ingestion of 400 mg. 
  • Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. 
  • pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine