Actinin

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  Subject Areas on Research

  • A small molecule inhibitor of alpha4 integrin-dependent cell migration. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Biochemical comparison of fast- and slow-contracting squid muscle. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Coordinate changes in fast thin filament and Z-line protein expression in the early response to chronic stimulation. 
  • Effect of microRNA modulation on bioartificial muscle function. 
  • Intragenic duplication and divergence in the spectrin superfamily of proteins. 
  • Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Simultaneous stretching and contraction of stress fibers in vivo. 
  • Simultaneous stretching and contraction of stress fibers in vivo. 
  • The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults. 
  • The actin membrane skeleton in Drosophila development. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The presence of two skeletal muscle alpha-actinins correlates with troponin-tropomyosin expression and Z-line width. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • Transitions from fetal to fast troponin T isoforms are coordinated with changes in tropomyosin and alpha-actinin isoforms in developing rabbit skeletal muscle. 
  • alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute