Actins

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  Subject Areas on Research

  • 7-Nitrobenz-2-oxa-1,3-diazole (NBD)--phallacidin: synthesis of a fluorescent actin probe. 
  • 8(S)-hydroxyeicosatetraenoic acid is the lipoxygenase metabolite of arachidonic acid that regulates epithelial cell migration in the rat cornea. 
  • A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. 
  • A PAK-like protein kinase is required for maturation of young hyphae and septation in the filamentous ascomycete Ashbya gossypii. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. 
  • A comparison of the atomic model of F-actin with cryo-electron micrographs of actin and decorated actin. 
  • A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. 
  • A maturational model for the study of airway smooth muscle adaptation to mechanical oscillation. 
  • A model for slow axonal transport and its application to neurofilamentous neuropathies. 
  • A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. 
  • A new dominant selectable marker for use in Cryptococcus neoformans. 
  • A new front in cell invasion: The invadopodial membrane. 
  • A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 
  • A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. 
  • A new structural state of myosin. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential? 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Actin Out: Regulation of the Synaptic Cytoskeleton. 
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. 
  • Actin and myosin biochemistry in relation to cytokinesis. 
  • Actin and myosin function in acanthamoeba. 
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. 
  • Actin cytoskeletal network in aging and cancer. 
  • Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Actin regulation and surface catalysis. 
  • Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. 
  • Actin-dependent myoid elongation in teleost rod inner/outer segments occurs in the absence of net actin polymerization. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. 
  • Adducin: structure, function and regulation. 
  • Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. 
  • Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. 
  • Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. 
  • Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. 
  • Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. 
  • Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Axonal transport of actin in rabbit retinal ganglion cells. 
  • BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. 
  • Bacterial actin homolog ParM: arguments for an apolar, antiparallel double helix. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. 
  • Beyond symmetry-breaking: competition and negative feedback in GTPase regulation. 
  • Bi-modal regulation of a formin by srGAP2. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Binding of deoxyribonuclease I to actin: a new way to visualize microfilament bundles in nonmuscle cells. 
  • Binding of myosin subfragment 1 to glycerinated insect flight muscle in the rigor state. 
  • Biochemical comparison of fast- and slow-contracting squid muscle. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin. 
  • Brain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells. 
  • Carbon monoxide promotes hypoxic pulmonary vascular remodeling. 
  • Cell Polarity in Yeast. 
  • Cell biology. Propelling progeny. 
  • Cell mechanics: dissecting the physical responses of cells to force. 
  • Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae. 
  • Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. 
  • Cellular basis for bimatoprost effects on human conventional outflow. 
  • Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype. 
  • Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease. 
  • Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. 
  • Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus. 
  • Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. 
  • Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Co-operativity in protein-protein association. The structure and stability of the actin filament. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Contractile proteins in Drosophila development. 
  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells. 
  • Coordinating cytoskeletal tracks to polarize cellular movements. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Cross-bridge angle distribution and thin filament stiffness in frog skeletal muscle fibers as studied by quick-freeze deep-etch electron microscopy. 
  • Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle. 
  • Cross-talk between TGF-beta1 and IL-6 in human trabecular meshwork cells. 
  • Crossbridges in the complete unit cell of rigor insect flight muscle imaged by three-dimensional reconstruction from oblique sections. 
  • Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. 
  • Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cytochalasins induce actin polymerization in human leukocytes. 
  • Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii. 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Cytoskeletal actin gene families of Xenopus borealis and Xenopus laevis. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac. 
  • Cytoskeleton. Evolution in bacteria. 
  • Dendritic spine geometry can localize GTPase signaling in neurons. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Developmental mechanism of the periodic membrane skeleton in axons. 
  • Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Diatom gliding is the result of an actin-myosin motility system. 
  • Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function. 
  • Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. 
  • Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse. 
  • Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? 
  • Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. 
  • Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Diffusion of low density lipoprotein-receptor complex on human fibroblasts. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Directed cell migration on fibronectin gradients: effect of gradient slope. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Dominant selection system for use in Cryptococcus neoformans. 
  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila spectrin: the membrane skeleton during embryogenesis. 
  • Drosophilia spectrin. I. Characterization of the purified protein. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer. 
  • EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils. 
  • Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia. 
  • Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. 
  • Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. 
  • Effects of inhibition of mitochondrial protein synthesis in skeletal muscle. 
  • Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. 
  • Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication. 
  • Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. 
  • Effects of taxol and Colcemid on myofibrillogenesis. 
  • Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. 
  • Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression. 
  • Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. 
  • Erythrocyte membrane tropomyosin. Purification and properties. 
  • Evidence that myosin does not contribute to force production in chromosome movement. 
  • Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. 
  • Experiments on rigor crossbridge action and filament sliding in insect flight muscle. 
  • Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family. 
  • F-actin aggregates in transformed cells. 
  • F-actin network formation in tethers and in pseudopods stimulated by chemoattractant. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • Fine-needle aspiration of neural lesions. 
  • Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescence studies on modes of cytochalasin B and phallotoxin action on cytoplasmic streaming in Chara. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Forces drive basement membrane invasion in Caenorhabditis elegans. 
  • Formation of myocardial zonal lesions. 
  • Formin' actin filament bundles. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Gene expression in the rectus abdominus muscle of patients with and without pelvic organ prolapse. 
  • Geometrical constraints affecting crossbridge formation in insect flight muscle. 
  • Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. 
  • Glutamate receptor activation regulates mRNA at both transcriptional and posttranscriptional levels. 
  • Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling. 
  • Granulocyte deformability and F-actin content: relationship to diabetes mellitus and retinopathy. 
  • Gross structural features of myosin head during sliding movement of actin as studied by quick-freeze deep-etch electron microscopy. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hedgehog pathway and pediatric nonalcoholic fatty liver disease. 
  • Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. 
  • High-affinity augmentation of endothelial cell attachment: long-term effects on focal contact and actin filament formation. 
  • Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • How vinculin regulates force transmission. 
  • Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. 
  • Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). 
  • In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation. 
  • In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s). 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells. 
  • Influence of food deprivation on intestinal cholecystokinin and somatostatin. 
  • Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma. 
  • Intraoperative floppy iris syndrome: report of a case and histopathologic analysis. 
  • Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. 
  • Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo. 
  • Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. 
  • Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments. 
  • JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. 
  • Kinesin motors as molecular machines. 
  • L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. 
  • Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. 
  • Length oscillation induces force potentiation in infant guinea pig airway smooth muscle. 
  • Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions. 
  • Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Long-term primary culture of epithelial cells from rainbow trout Oncorhynchus mykiss) liver. 
  • Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers. 
  • Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. 
  • MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans. 
  • MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • Mantle zone lymphoma in a gastric glomus tumor. 
  • Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study. 
  • Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. 
  • Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii. 
  • Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Microrheology probes length scale dependent rheology. 
  • Microtubule disruption leads to cellular contraction in human trabecular meshwork cells. 
  • Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region. 
  • Modeling rigor cross-bridge patterns in muscle I. Initial studies of the rigor lattice of insect flight muscle. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Modulation of microfilament protein composition by transfected cytoskeletal actin genes. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Modulation of spectrin-actin assembly by erythrocyte adducin. 
  • Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine. 
  • Molecular genetic dissection of myosin heavy chain function. 
  • Molecular mobility on the cell surface. 
  • Monocyte chemoattractant activity of Ser195-->Ala active site mutant recombinant alpha-thrombin. 
  • Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. 
  • Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. 
  • Myofibroblasts contribute to but are not necessary for wound contraction. 
  • Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. 
  • Myosin S2 origins track evolution of strong binding on actin by azimuthal rolling of motor domain. 
  • Myosin filament structure and myosin crossbridge dynamics in fish and insect muscles. 
  • Myosin head configuration in relaxed insect flight muscle: x-ray modeled resting cross-bridges in a pre-powerstroke state are poised for actin binding. 
  • Myosin-actin motors: the partnership goes atomic. 
  • Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10). 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • Neutrophil elastase induces mucus cell metaplasia in mouse lung. 
  • Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. 
  • Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. 
  • Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. 
  • Opposing roles for actin in Cdc42p polarization. 
  • Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. 
  • Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas. 
  • Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. 
  • Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats. 
  • Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad. 
  • Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function. 
  • Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages. 
  • Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. 
  • Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. 
  • Plasma gelsolin and circulating actin correlate with hemodialysis mortality. 
  • Polymerization of actin. IV. Role of Ca++ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm. 
  • Pretranslational regulation of myoglobin gene expression. 
  • Progesterone receptor activity in leiomyomatosis peritonealis disseminata. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Protein kinase C beta II specifically binds to and is activated by F-actin. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • Proteins closely related to spectrin and ankyrin are general components of cell membranes. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Quantitative analysis of macrophages and perisinusoidal cells in primary biliary cirrhosis. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline. 
  • Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis. 
  • Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. 
  • Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Red blood cell and fibroblast membranes in Duchenne and myotonic muscular dystrophy. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Reduced synthesis of pp60src and expression of the transformation-related phenotype in interferon-treated Rous sarcoma virus-transformed rat cells. 
  • Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats. 
  • Regulation of macrophage motility by Irgm1. 
  • Regulation of microfilaments and microtubules by calcium and cyclic AMP. 
  • Regulation of spine structural plasticity by Arc/Arg3.1. 
  • Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. 
  • Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. 
  • Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces. 
  • Response of blood leukocytes to thrombin receptor peptides. 
  • Reverse actin sliding triggers strong myosin binding that moves tropomyosin. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Rigor crossbridge structure in tilted single filament layers and flared-X formations from insect flight muscle. 
  • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A. 
  • Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. 
  • Rvs161p and sphingolipids are required for actin repolarization following salt stress. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy. 
  • Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. 
  • Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Shear-induced force transmission in a multicomponent, multicell model of the endothelium. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles. 
  • Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR. 
  • Singularity in polarization: rewiring yeast cells to make two buds. 
  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. 
  • Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. 
  • Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. 
  • Stepping between membrane microdomains. 
  • Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone. 
  • Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion. 
  • Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. 
  • Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. 
  • Superoxide-mediated actin response in post-hypoxic endothelial cells. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. 
  • Symmetry breaking and the establishment of cell polarity in budding yeast. 
  • Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease. 
  • Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. 
  • Temporal regulation of morphogenetic events in Saccharomyces cerevisiae. 
  • Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. 
  • Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine. 
  • The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. 
  • The actin membrane skeleton in Drosophila development. 
  • The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. 
  • The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. 
  • The discovery of the prokaryotic cytoskeleton: 25th anniversary. 
  • The effect of halothane on cultured fibroblasts and neuroblastoma cells. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The junctional complex of the membrane skeleton. 
  • The metastatic odyssey: the integrin connection. 
  • The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. 
  • The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. 
  • The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. 
  • The role of F-actin and myosin in epithelial cell rheology. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The role of the cytoskeleton in aging. 
  • The role of the lens actin cytoskeleton in fiber cell elongation and differentiation. 
  • The spectrin-actin junction of erythrocyte membrane skeletons. 
  • The structure of insect flight muscle in the presence of AMPPNP. 
  • The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. 
  • The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42. 
  • Therapeutic targets in focal and segmental glomerulosclerosis. 
  • Three-dimensional image reconstruction of insect flight muscle. I. The rigor myac layer. 
  • Three-dimensional image reconstruction of insect flight muscle. II. The rigor actin layer. 
  • Three-dimensional reconstruction of rigor insect flight muscle from tilted thin sections. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • Tomographic 3D reconstruction of quick-frozen, Ca2+-activated contracting insect flight muscle. 
  • Tomographic three-dimensional reconstruction of insect flight muscle partially relaxed by AMPPNP and ethylene glycol. 
  • Toxin injury-dependent switched expression between EF-1 alpha and its sister, S1, in rat skeletal muscle. 
  • Tracking shallow chemical gradients by actin-driven wandering of the polarization site. 
  • Transcription inhibits the replication of autonomously replicating plasmids in human cells. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. 
  • Tropomyosin: a new component of the erythrocyte membrane skeleton. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
  • Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans. 
  • Two attached non-rigor crossbridge forms. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. 
  • Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. 
  • Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice. 
  • Unified biophysical mechanism for cell-shape oscillations and cell ingression. 
  • Unphosphorylated gelsolin is localized in regions of cell-substratum contact or attachment in Rous sarcoma virus-transformed rat cells. 
  • Variable presentation of nemaline myopathy: novel mutation of alpha actin gene. 
  • Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. 
  • Wound healing: The power of the purse string. 
  • X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle. 
  • X-ray diffraction indicates that active cross-bridges bind to actin target zones in insect flight muscle. 
  • X-ray diffraction studies of striated muscles. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. 
  • crinkled reveals a new role for Wingless signaling in Drosophila denticle formation. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology