Acyltransferases

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  Subject Areas on Research

  • A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. 
  • A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. 
  • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. 
  • Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. 
  • Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen. 
  • Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution. 
  • Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices. 
  • Analysis of a chalcone synthase mutant in Ipomoea purpurea reveals a novel function for flavonoids: amelioration of heat stress. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. 
  • Bacterial lipids: metabolism and membrane homeostasis. 
  • Cell surface polarization during yeast mating. 
  • Characterization of Unexpected Self-Acylation Activity of Acyl Carrier Proteins in a Modular Type I Apicomplexan Polyketide Synthase. 
  • Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry. 
  • Chasing acyl carrier protein through a catalytic cycle of lipid A production. 
  • Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis. 
  • Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae). 
  • Comparative genomics and regulatory evolution: conservation and function of the Chs and Apetala3 promoters. 
  • Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. 
  • Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans. 
  • Crystalline arrays of the Escherichia coli sn-glycerol-3-phosphate acyltransferase, an integral membrane protein. 
  • Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. 
  • Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. 
  • Discovery and Optimization of a Porcupine Inhibitor. 
  • Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia proteamaculans. 
  • Discovery of new biosynthetic pathways: the lipid A story. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Enzymes of ceramide biosynthesis. 
  • Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. 
  • Evolutionary rate variation in anthocyanin pathway genes. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses. 
  • Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. 
  • Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. 
  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 
  • Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. 
  • Functional regulation of Wnt protein through post-translational modifications. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. 
  • Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. 
  • Hepatic enzymes of sphingolipid and glycerolipid biosynthesis in rats from Spacelab 3. 
  • Hepatic monoacylglycerol acyltransferase: ontogeny and characterization of an activity associated with the chick embryo. 
  • Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. 
  • Increases in serum sphingomyelin by 17 beta-estradiol. 
  • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. 
  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. 
  • Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. 
  • Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. 
  • Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. 
  • Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. 
  • N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. 
  • NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. 
  • Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase. 
  • Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis. 
  • PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. 
  • PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. 
  • Patterns of evolutionary rate variation among genes of the anthocyanin biosynthetic pathway. 
  • Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. 
  • Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. 
  • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. 
  • Precise regulation of porcupine activity is required for physiological Wnt signaling. 
  • Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. 
  • Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs. 
  • Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. 
  • Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors. 
  • Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. 
  • Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 
  • Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. 
  • Structural model of human PORCN illuminates disease-associated variants and drug-binding sites. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling. 
  • Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis. 
  • The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. 
  • The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition. 
  • The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis. 
  • The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. 
  • The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack. 
  • Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. 
  • Ventricular arrhythmia in the X-linked cardiomyopathy Barth syndrome. 
  • Wnt addiction of genetically defined cancers reversed by PORCN inhibition. 
  • Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. 
  • Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. 
  • [A transformylation reaction--transfer of an N-formyl residue to amino acids and peptides in nucleophilic groups--as a side reaction of peptide synthesis]. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry