Adenine Phosphoribosyltransferase

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  Subject Areas on Research

  • Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes. 
  • Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase. 
  • Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Purine reutilization and synthesis de novo in APRT deficient long-term lymphocyte lines. 
  • Purine reutilization and synthesis de novo in long-term human lymphocyte cell lines deficient in adenine phosphoribosyltransferase activity. 
  • Purine synthesis and excretion in mutants of the WI-L2 human lymphoblastoid line deficient in adenosine kinase (AK) and adenine phosphoribosyltransferase (APRT). 
  • Purine toxicity in human lymphoblasts.