Cyclic AMP

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  Subject Areas on Research

  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. 
  • 8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells. 
  • A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. 
  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. 
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. 
  • A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene. 
  • A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II. 
  • Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. 
  • Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin. 
  • Adenosine nucleotides in bile. 
  • Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis. 
  • Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. 
  • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Adrenergic receptors: molecular mechanisms of clinically relevant regulation. 
  • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. 
  • Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. 
  • Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Androgen receptor activation by G(s) signaling in prostate cancer cells. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics. 
  • Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine. 
  • Beta adrenergic receptors in lymphocyte subpopulations. 
  • Beta-2 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat. 
  • Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. 
  • Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. 
  • Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. 
  • Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells. 
  • Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. 
  • Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • Biochemical actions of follice-stimulating hormone in the sertoli cell of the rat testis. 
  • Biochemical changes in leukocytes in response to chemoattractants. 
  • Biological activity of agarose-immobilized catecholamines. 
  • CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • CFTR regulation of epithelial sodium channel. 
  • Calcitonin gene-related peptide (CGRP) in the developing mouse limb. 
  • Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. 
  • Calmodulin, cell growth and gene expression. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. 
  • Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. 
  • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. 
  • Characterization and follicle stimulating hormone activation of Sertoli cell cyclic AMP-dependent protein kinases. 
  • Characterization of a spectrophotometric assay for cAMP phosphodiesterase. 
  • Characterization of mediators of insulin action. 
  • Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. 
  • Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. 
  • Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum. 
  • Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex. 
  • Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum. 
  • Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. 
  • Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Cocaine and beta-adrenergic receptor function in pregnant myometrium. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. 
  • Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. 
  • Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. 
  • Conserved cAMP signaling cascades regulate fungal development and virulence. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Coupled events in the early biochemical actions of FSH on the Sertoli cells of the testis. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Covalent labelling of ligand binding sites of human placental S-adenosylhomocysteine hydrolase with 8-azido derivatives of adenosine and cyclic AMP. 
  • Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. 
  • Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. 
  • Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Cyclic AMP signaling in Cryptococcus neoformans. 
  • Cyclic AMP, morphine, met-enkephalin and neuronal firing. 
  • Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility. 
  • Cyclic adenosine 3':5'-monophosphate-dependent protein kinase. 
  • Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. 
  • Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death. 
  • Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. 
  • Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. 
  • Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. 
  • Developmental coordination of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and acute hCG responsiveness in cultured and freshly harvested porcine granulosa cells. 
  • Diarrhea, demography and cell signaling: lessons from microbial toxins. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A. 
  • Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 
  • Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Divergent Roles for cAMP-PKA Signaling in the Regulation of Filamentous Growth in Saccharomyces cerevisiae and Saccharomyces bayanus. 
  • Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion. 
  • Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? 
  • Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. 
  • Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 
  • Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. 
  • Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase. 
  • Effect of vasopressin and serosal hypertonicity on toad urinary bladder. 
  • Effector coupling mechanisms of the cloned 5-HT1A receptor. 
  • Effects of colchicine and cytochalasin B on vasopressin- and cyclic adenosine monophosphate-induced changes in toad urinary bladder. 
  • Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei. 
  • Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. 
  • Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades. 
  • Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction. 
  • Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. 
  • Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance. 
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism. 
  • FSH-induction of androgen binding protein in testes of Sertoli cell-only rats. 
  • Factors affecting Sertoli cell function in the testis. 
  • Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin. 
  • Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis. 
  • Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. 
  • G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • GABAB receptor-mediated effects in synaptosomes of lethargic (lh/lh) mice. 
  • GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. 
  • GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • GSK3 involvement in amylin signaling in isolated rat soleus muscle. 
  • Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. 
  • Galphaz negatively regulates insulin secretion and glucose clearance. 
  • Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. 
  • Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. 
  • Genetics of Cryptococcus neoformans. 
  • Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. 
  • Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. 
  • HeLa cells express cAMP-inhibitable sodium-dependent phosphate uptake. 
  • High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. 
  • Histamine stimulates calcium-mediated protein phosphorylation in a colonic epithelial cell line. 
  • Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst. 
  • Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. 
  • Hyperparathyroidism associated with the enlargement of two or three parathyroid glands. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • IL-1 receptors: structure and signals. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of muscarinic acetylcholine receptors in isolated canine lingual epithelia via voltage clamp measurements. 
  • Identification of negative and positive regulatory elements in the human renin gene. 
  • Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver. 
  • Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line. 
  • Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones. 
  • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. 
  • In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids. 
  • In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase. 
  • In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. 
  • Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. 
  • Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone. 
  • Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model. 
  • Inhibition of the dopamine D1 receptor signaling by PSD-95. 
  • Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. 
  • Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages. 
  • Interaction between cyclic nucleotides and herpes simplex viruses: productive infection. 
  • Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. 
  • Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. 
  • Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. 
  • Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis. 
  • LTP in the mouse nucleus accumbens is developmentally regulated. 
  • LW protein: a promiscuous integrin receptor activated by adrenergic signaling. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay. 
  • Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • Measurement of plasma adenosine 3',5'-monophosphate. 
  • Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. 
  • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 
  • Mechanisms involved in adrenergic receptor desensitization. 
  • Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. 
  • Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. 
  • Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 
  • Metabolite gene regulation of the L-arabinose operon in Escherichia coli with indoleacetic acid and other indole derivatives. 
  • Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon. 
  • Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. 
  • Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity. 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of thyroidal radioiodine uptake by theophylline. 
  • Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR). 
  • Molecular characterization of the human delta opioid receptor in lung cancer. 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. 
  • NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. 
  • Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release. 
  • Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. 
  • Neurohormonal regulation of pancreatic secretion. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Neuroprotective effects of group III mGluR in traumatic neuronal injury. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate. 
  • Novel adamantyl cannabinoids as CB1 receptor probes. 
  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Nucleotide receptors regulate membrane ion transport in renal epithelial cells. 
  • Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. 
  • Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. 
  • Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. 
  • Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms. 
  • Ovine placental lactogen inhibits glucagon-induced glycogenolysis in fetal rat hepatocytes. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. 
  • Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. 
  • Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. 
  • Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. 
  • Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice. 
  • Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices. 
  • Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices. 
  • Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein. 
  • Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors. 
  • Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase. 
  • Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Physiological responses to catecholamine infusions in type A and type B men. 
  • Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells. 
  • Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. 
  • Polarized expression of cAMP-activated chloride channels in isolated epithelial cells. 
  • Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex. 
  • Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes. 
  • Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. 
  • Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2. 
  • Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. 
  • Protein kinase inhibitor in sertoli cell-enriched rat testis. Specific regulation by follicle-stimulating hormone. 
  • Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum. 
  • Protein phosphorylation: hormones, drugs, and bioregulation. 
  • Pseudohypoparathyroidism type II: a possible defect in the reception of the cyclic AMP signal. 
  • Quantifying ligand bias at seven-transmembrane receptors. 
  • Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. 
  • Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor. 
  • Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages. 
  • Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts. 
  • Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. 
  • Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. 
  • Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. 
  • Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S. 
  • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. 
  • Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells. 
  • Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP. 
  • Regulation of membrane chloride currents in rat bile duct epithelial cells. 
  • Regulation of microfilaments and microtubules by calcium and cyclic AMP. 
  • Regulation of protein kinase inhibitor by follicle-stimulating hormone in Sertoli cells in vitro. 
  • Regulation of protein kinases by pseudosubstrate prototopes. 
  • Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. 
  • Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. 
  • Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. 
  • Regulation of the Na/H exchanger regulatory factor in OK cells. 
  • Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP. 
  • Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA. 
  • Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. 
  • Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. 
  • Renal cyclic adenosine monophosphate: an accurate index of parathyroid function. 
  • Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. 
  • Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. 
  • Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. 
  • Role of cyclic AMP in the actions of luteinizing hormone on steroidogenesis in the corpus luteum. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Role of sympathetic neurons in biochemical and functional development of the kidney: neonatal sympathectomy with 6-hydroxydopamine. 
  • Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. 
  • Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Signal transduction cascades regulating fungal development and virulence. 
  • Signal transduction. Bringing channels closer to the action! 
  • Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes. 
  • Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. 
  • Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Steady-state kinetic study of rabbit muscle phosphofructokinase. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate. 
  • Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate. 
  • Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. 
  • Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. 
  • Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. 
  • Studies of dopamine pharmacology in molluscs. 
  • Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. 
  • Study of the interaction of adenylyl imidodiphosphate with rabbit muscle phosphofructokinase. 
  • Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells. 
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. 
  • T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs. 
  • TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. 
  • TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. 
  • TRPV1 receptors mediate particulate matter-induced apoptosis. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. 
  • Testicular adenosine 3':5'-monophosphate-dependent protein kinase. Regulation by follicle-stimulating hormone. 
  • The Akt-GSK-3 signaling cascade in the actions of dopamine. 
  • The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host. 
  • The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. 
  • The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The adrenergic receptors. 
  • The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. 
  • The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. 
  • The biochemistry of haemostasis. 
  • The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 
  • The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP. 
  • The effect of transforming growth factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. 
  • The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The impact of aging on adrenergic receptor function: clinical and biochemical aspects. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915. 
  • The relationship between hostility and beta-adrenergic receptor physiology in health young males. 
  • The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. 
  • The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation. 
  • The role of the prostaglandin EP4 receptor in the regulation of human outflow facility. 
  • The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine). 
  • The syndrome of hyperostosis and hyperphosphatemia. 
  • Tissue specificity of renin promoter activity and regulation in mice. 
  • Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. 
  • Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Turning off the signal: desensitization of beta-adrenergic receptor function. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. 
  • Type II cAMP-dependent protein kinase is associated with the rabbit kidney brush border membranes. 
  • Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus. 
  • Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. 
  • Urinary cyclic adenosine monophosphate as an aid in the diagnosis of hyperparathyroidism. 
  • Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. 
  • Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. 
  • Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. 
  • [Action of vasopressin on the luminal surface of the toad urinary bladder (proceedings)]. 
  • beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions. 
  • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. 
  • beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. 
  • beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. 
  • beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. 
  • cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes. 
  • cAMP and calcemia. 
  • cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes. 
  • cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. 
  • cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. 
  • cAMP-dependent regulatory processes in the acquisition and control of sperm flagellar movement. 
  • cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. 
  • p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
• 

  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Middleton, John Paul, Associate Professor of Medicine, Medicine, Nephrology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology
  • Yang, Yiping, Professor of Medicine, Immunology
  • Zennadi, Rahima, Associate Professor in Medicine, Medicine, Hematology