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Subject Areas on Research
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17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia.
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5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.
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8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells.
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A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange.
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A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
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A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.
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A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
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A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
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A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.
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A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
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A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells.
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A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.
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A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene.
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A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
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A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.
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A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+.
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A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.
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Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2+ calmodulin-dependent protein kinase II.
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Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.
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Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling.
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Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin.
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Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth.
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Adenosine nucleotides in bile.
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Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.
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Adenylyl cyclase expression and modulation of cAMP in rat taste cells.
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Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.
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Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.
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Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.
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Adrenergic receptors: molecular mechanisms of clinically relevant regulation.
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Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.
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Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes.
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Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.
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Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol.
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Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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Analysis of recombinant Phex: an endopeptidase in search of a substrate.
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Androgen receptor activation by G(s) signaling in prostate cancer cells.
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Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
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Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds.
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Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine.
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Beta adrenergic receptors in lymphocyte subpopulations.
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Beta-2 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat.
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Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism.
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Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.
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Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
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Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.
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Beta-adrenergic receptors: recognition and regulation.
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Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells.
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Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.
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Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers.
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Biochemical actions of follice-stimulating hormone in the sertoli cell of the rat testis.
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Biochemical changes in leukocytes in response to chemoattractants.
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Biological activity of agarose-immobilized catecholamines.
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CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.
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CFTR as a cAMP-dependent regulator of sodium channels.
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Calcitonin gene-related peptide (CGRP) in the developing mouse limb.
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Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers.
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Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.
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Calmodulin, cell growth and gene expression.
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Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.
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Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
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Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number.
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Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
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Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair.
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Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors.
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Central regulation of photosensitive membrane turnover in the lateral eye of Limulus, II: octopamine acts via adenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding.
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Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp.
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Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase.
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Characteristics of cultured human renal cortical epithelia.
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Characterization and follicle stimulating hormone activation of Sertoli cell cyclic AMP-dependent protein kinases.
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Characterization of a spectrophotometric assay for cAMP phosphodiesterase.
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Characterization of mediators of insulin action.
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Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.
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Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex.
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Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver.
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Chronic guanethidine treatment increases cardiac beta-adrenergic receptors.
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Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum.
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Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
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Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP.
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Cl- and K+ transport in human biliary cell lines.
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Cocaine and beta-adrenergic receptor function in pregnant myometrium.
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Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
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Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
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Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.
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Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
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Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties.
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Conserved cAMP signaling cascades regulate fungal development and virulence.
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Coupled events in the early biochemical actions of FSH on the Sertoli cells of the testis.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Covalent labelling of ligand binding sites of human placental S-adenosylhomocysteine hydrolase with 8-azido derivatives of adenosine and cyclic AMP.
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Cross talk between the cell wall integrity and cyclic AMP/protein kinase A pathways in Cryptococcus neoformans.
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Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation.
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Crucial role of copper in detection of metal-coordinating odorants.
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Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli.
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Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
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Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors.
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Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.
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Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
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Cyclic AMP signaling in Cryptococcus neoformans.
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Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.
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Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
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Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility.
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Cyclic adenosine 3':5'-monophosphate-dependent protein kinase.
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Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes.
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Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels.
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Decreased intracellular potassium levels underlie increased progesterone synthesis during ovarian follicular atresia.
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Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.
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Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.
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Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.
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Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
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Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.
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Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.
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Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.
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Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.
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Developmental coordination of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and acute hCG responsiveness in cultured and freshly harvested porcine granulosa cells.
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Diarrhea, demography and cell signaling: lessons from microbial toxins.
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Differential effect of cyclic adenosine monophosphate on the secretion of human placental lactogen and human chorionic gonadotropin.
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Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver.
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Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells.
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Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling.
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Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
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Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.
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Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
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Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
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Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.
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Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter.
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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
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Divergent Roles for cAMP-PKA Signaling in the Regulation of Filamentous Growth in Saccharomyces cerevisiae
and Saccharomyces bayanus
.
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Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion.
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Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?
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Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway.
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Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP.
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ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia.
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Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
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Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro.
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Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase.
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Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes.
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Effect of vasopressin and serosal hypertonicity on toad urinary bladder.
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Effector coupling mechanisms of the cloned 5-HT1A receptor.
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Effects of colchicine and cytochalasin B on vasopressin- and cyclic adenosine monophosphate-induced changes in toad urinary bladder.
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Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei.
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Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA.
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Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
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Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation.
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Endosomal cAMP production broadly impacts the cellular phosphoproteome.
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Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction.
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Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells.
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Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Evidence for a second alpha 2-macroglobulin receptor.
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Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
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Expression of an abundant alternatively spliced form of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is not associated with a cAMP-activated chloride conductance.
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Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
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Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells.
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FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism.
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FSH-induction of androgen binding protein in testes of Sertoli cell-only rats.
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Factors affecting Sertoli cell function in the testis.
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Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin.
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Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis.
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Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis.
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Forskolin stimulation of water and cation permeability in aquaporin 1 water channels.
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From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.
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G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
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G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
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G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
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GSK3 involvement in amylin signaling in isolated rat soleus muscle.
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Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae.
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Galphaz negatively regulates insulin secretion and glucose clearance.
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Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.
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Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.
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Genetics of Cryptococcus neoformans.
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Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
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Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.
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HeLa cells express cAMP-inhibitable sodium-dependent phosphate uptake.
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Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.
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Histamine stimulates calcium-mediated protein phosphorylation in a colonic epithelial cell line.
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Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues.
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Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.
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Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation.
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Hormones, receptors, and cyclic AMP: their role in target cell refractoriness.
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Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst.
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Hydraulic pressure stimulates adenosine 3',5'-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal.
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Hyperparathyroidism associated with the enlargement of two or three parathyroid glands.
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Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.
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IL-1 receptors: structure and signals.
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Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
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Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism.
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Identification of muscarinic acetylcholine receptors in isolated canine lingual epithelia via voltage clamp measurements.
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Identification of negative and positive regulatory elements in the human renin gene.
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Identification of three protein kinases which phosphorylate threonyl-tRNA synthetase from rat liver.
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Idiopathic ventricular outflow tract tachycardia.
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Imidazole acetic acid as a substitute for cAMP.
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Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line.
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Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones.
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Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.
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In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids.
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In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
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Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections.
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Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.
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Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
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Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone.
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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
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Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}.
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Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
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Intracellular mechanisms of gonadotropin-stimulated gene expression in granulosa cells.
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Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
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Isolated hormone receptors: physiologic and clinical implications.
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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.
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Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase.
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Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis.
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LTP in the mouse nucleus accumbens is developmentally regulated.
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LW protein: a promiscuous integrin receptor activated by adrenergic signaling.
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LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
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Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene.
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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay.
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Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.
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Loss of tissue sensitivity to growth hormone during maternal deprivation in rats.
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Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells.
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MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.
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Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
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Mechanisms involved in adrenergic receptor desensitization.
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Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase.
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Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.
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Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.
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Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells.
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Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
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Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli L-arabinose operon.
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Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.
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Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity.
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Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.
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Modeling mutant phenotypes and oscillatory dynamics in the \emph{Saccharomyces cerevisiae} cAMP-PKA pathway
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
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Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR).
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Molecular characterization of the human delta opioid receptor in lung cancer.
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Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor.
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Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
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Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.
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NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3.
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NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.
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Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes.
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Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release.
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Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation.
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Neurohormonal regulation of pancreatic secretion.
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Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections.
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Neuroprotective effects of group III mGluR in traumatic neuronal injury.
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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
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New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system.
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Noradrenaline treatment of rats stimulates H2O2 generation in liver mitochondria.
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Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate.
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Novel adamantyl cannabinoids as CB1 receptor probes.
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Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion.
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Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression.
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Nucleotide receptors regulate membrane ion transport in renal epithelial cells.
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Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.
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Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase.
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Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms.
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Ovine placental lactogen inhibits glucagon-induced glycogenolysis in fetal rat hepatocytes.
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PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
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PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
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Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity.
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Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro.
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Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans.
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Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
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Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
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Pharmacological characterizations of adrenergic receptors in human adipocytes.
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Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice.
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Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices.
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Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices.
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Phosducin, potential role in modulation of olfactory signaling.
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Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.
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Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
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Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
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Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase.
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Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization.
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Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase.
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Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate.
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Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.
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Physiological receptors as physicochemical entities.
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Physiological responses to catecholamine infusions in type A and type B men.
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Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells.
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Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans.
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Polarized expression of cAMP-activated chloride channels in isolated epithelial cells.
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Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex.
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Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
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Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
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Primary Blast Injury Depressed Hippocampal Long-Term Potentiation through Disruption of Synaptic Proteins.
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Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2.
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Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization.
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Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells.
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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
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Protein kinase inhibitor in sertoli cell-enriched rat testis. Specific regulation by follicle-stimulating hormone.
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Protein phosphorylation: hormones, drugs, and bioregulation.
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Pseudohypoparathyroidism type II: a possible defect in the reception of the cyclic AMP signal.
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Quantifying ligand bias at seven-transmembrane receptors.
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Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function.
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase.
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Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor.
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Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.
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Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts.
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Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
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Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.
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Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
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Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S.
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Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
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Regulation of beta-adrenergic receptors by phospholipid methylation.
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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
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Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
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Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP.
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Regulation of membrane chloride currents in rat bile duct epithelial cells.
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Regulation of microfilaments and microtubules by calcium and cyclic AMP.
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Regulation of protein kinase inhibitor by follicle-stimulating hormone in Sertoli cells in vitro.
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Regulation of protein kinases by pseudosubstrate prototopes.
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Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium.
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Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli.
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Regulation of the Na/H exchanger regulatory factor in OK cells.
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Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP.
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Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA.
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Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA.
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Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.
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Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
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Renal cyclic adenosine monophosphate: an accurate index of parathyroid function.
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Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
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Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
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Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes.
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Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
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Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor.
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Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin.
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Role of sympathetic neurons in biochemical and functional development of the kidney: neonatal sympathectomy with 6-hydroxydopamine.
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Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment.
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Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes.
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
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Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
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Signal transduction cascades regulating fungal development and virulence.
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Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes.
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Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells.
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Simulation of aggregation in Dictyostelium using the Cell Programming Language.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis.
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Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.
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Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage.
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Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.
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Steady-state kinetic study of rabbit muscle phosphofructokinase.
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Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase.
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Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
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Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate.
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Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate.
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Stretch-regulated exocytosis/endocytosis in bladder umbrella cells.
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Structural basis for μ-opioid receptor binding and activation.
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Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group.
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Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.
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Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin.
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Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant.
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Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).
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Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists.
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Studies of dopamine pharmacology in molluscs.
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Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.
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Study of the interaction of adenylyl imidodiphosphate with rabbit muscle phosphofructokinase.
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Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.
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Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells.
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Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
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TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder.
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TLR4-mediated expulsion of bacteria from infected bladder epithelial cells.
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TRPV1 receptors mediate particulate matter-induced apoptosis.
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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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Techniques for the study of the biochemical basis of drug action.
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Testicular adenosine 3':5'-monophosphate-dependent protein kinase. Regulation by follicle-stimulating hormone.
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The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans.
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The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.
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The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults.
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The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.
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The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
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The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.
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The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans.
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The adrenergic receptors.
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The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.
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The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis.
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The biochemistry of haemostasis.
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The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
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The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP.
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The effect of transforming growth factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells.
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The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
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The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides.
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The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C.
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The impact of aging on adrenergic receptor function: clinical and biochemical aspects.
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The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery.
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The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
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The relationship between hostility and beta-adrenergic receptor physiology in health young males.
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The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
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The role of the prostaglandin EP4 receptor in the regulation of human outflow facility.
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The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine).
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The syndrome of hyperostosis and hyperphosphatemia.
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Tissue specificity of renin promoter activity and regulation in mice.
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Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.
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Toxicity of methoxyacetic acid in cultured human luteal cells.
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Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.
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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
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Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.
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Transcriptional regulation of matrix gla protein.
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Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.
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Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.
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Treatment-related biomarkers in pulmonary hypertension.
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Turning off the signal: desensitization of beta-adrenergic receptor function.
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Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.
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Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.
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Type II cAMP-dependent protein kinase is associated with the rabbit kidney brush border membranes.
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Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus.
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Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland.
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UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
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Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34).
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Urinary cyclic adenosine monophosphate as an aid in the diagnosis of hyperparathyroidism.
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Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells.
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Vapor detection and discrimination with a panel of odorant receptors.
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Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.
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Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
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[Action of vasopressin on the luminal surface of the toad urinary bladder (proceedings)].
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beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions.
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beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.
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beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.
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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
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beta-arrestin-biased agonism at the beta2-adrenergic receptor.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.
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cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes.
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cAMP and calcemia.
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cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.
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cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
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cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes.
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cAMP-dependent regulatory processes in the acquisition and control of sperm flagellar movement.
-
cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.
-
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
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β Cell tone is defined by proglucagon peptides through cAMP signaling.
-
Keywords of People
-
Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
-
Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
-
Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology
-
Zennadi, Rahima,
Associate Professor in Medicine,
Pathology