Adenosine Diphosphate

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  Subject Areas on Research

  • 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. 
  • A Bigger Look Into the "Therapeutic Window" of Platelet Reactivity to Adenosine Diphosphate. 
  • A kinesin motor in a force-producing conformation. 
  • A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase. 
  • A new method of representing drug-induced platelet inhibition: better description of time course, response variability, non-response, and heightened activity. 
  • A novel method to assess platelet inhibition by eptifibatide with thrombelastograph. 
  • ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films. 
  • Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study. 
  • Adenine nucleotides of ischemic intestine do not reflect injury. 
  • Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Adenosine nucleotides in bile. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism. 
  • An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 
  • Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. The GUSTO-III Platelet Substudy. 
  • Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. 
  • Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. 
  • Assessment of the number of nucleotide binding sites on chloroplast coupling factor 1 by the continuous variation method. 
  • Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. 
  • Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. 
  • Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study. 
  • Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase. 
  • Characterization of nucleotide binding sites on chloroplast coupling factor 1. 
  • Characterization of three-subunit chloroplast coupling factor. 
  • Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. 
  • Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial). 
  • Clinical validation of AggreGuide A-100 ADP, a novel assay for assessing the antiplatelet effect of oral P2Y12 antagonists. 
  • Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding. 
  • Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Comparing Inverse Probability of Treatment Weighting and Instrumental Variable Methods for the Evaluation of Adenosine Diphosphate Receptor Inhibitors After Percutaneous Coronary Intervention. 
  • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. 
  • Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. 
  • Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. 
  • Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Direct effects of CO on cerebral energy metabolism in bloodless rats. 
  • Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. 
  • Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium. 
  • Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine. 
  • Effects of hypoxia and toxicant exposure on adenylate energy charge and cytosolic ADP concentrations in abalone. 
  • Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy. 
  • Energy metabolism and in vivo cytochrome c oxidase redox relationships in hypoxic rat brain. 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. 
  • Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes? 
  • Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance': a rebuttal. 
  • Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Function of tightly bound nucleotides on membrane-bound chloroplast coupling factor. 
  • Further characterization of nucleotide binding sites on chloroplast coupling factor one. 
  • G-protein-coupled receptors as signaling targets for antiplatelet therapy. 
  • Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. 
  • Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction. 
  • High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells. 
  • Homologous Recombination Repair Gene Variants and Outcomes Among Patients With Prostate Cancer Treated With Poly (ADP-ribose) Polymerase Inhibitors. 
  • Hostility and platelet reactivity in individuals without a history of cardiovascular disease events. 
  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Immunity to thrombotic events is achievable if we stop the guessing game: is this the major hidden message from GRAVITAS? 
  • Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account. 
  • In vitro effects of recombinant activated factor VIIa (NovoSeven) on clopidogrel-induced platelet inhibition. 
  • Influence of CYP2C19*2 and *3 loss-of-function alleles on the pharmacodynamic effects of standard- and high-dose clopidogrel in East Asians undergoing percutaneous coronary intervention: the results of the ACCEL-DOUBLE-2N3 study. 
  • Interaction of nucleotides with chloroplast coupling factor 1. 
  • Interactions between nucleotide binding sites on chloroplast coupling factor during ATP hydrolysis. 
  • Kinesin motors as molecular machines. 
  • Kinetics of allosteric enzymes. 
  • Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. 
  • Mechanical loading stimulates ecto-ATPase activity in human tendon cells. 
  • Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure. 
  • Molecular strategies for the treatment of diabetes. 
  • Monitoring platelet inhibition during chronic oral platelet glycoprotein IIb/IIIa blockade: are we missing something? 
  • NAD+ modulates p53 DNA binding specificity and function. 
  • Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. 
  • Normal cardiac function in mice with supraphysiological cardiac creatine levels. 
  • Nucleotide interactions with the dicyclohexylcarbodiimide-sensitive adenosinetriphosphatase from spinach chloroplasts. 
  • Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Pharmacodynamic effects of clopidogrel in pediatric cardiac patients: a comparative study of platelet aggregation response. 
  • Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine. 
  • Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients. 
  • Platelet inhibition by low-dose aspirin is not influenced by body mass or weight. 
  • Platelet reactivity to adenosine diphosphate and long-term ischemic event occurrence following percutaneous coronary intervention: a potential antiplatelet therapeutic target. 
  • Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish. 
  • Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria. 
  • Prasugrel. 
  • Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Reversible uncoupling of oxidative phosphorylation at low oxygen tension. 
  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. 
  • Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. 
  • SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. 
  • Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation. 
  • Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. 
  • Steady state kinetics of soluble and membrane-bound mitochondrial ATPase. 
  • Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA. 
  • Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. 
  • The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. 
  • The bleeding diathesis in human glycogen storage disease type I: in vitro identification of a naturally occurring inhibitor of ristocetin-induced platelet aggregation. 
  • The difference between clopidogrel responsiveness and posttreatment platelet reactivity. 
  • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. 
  • The effects of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography. 
  • The influence of red wine or white wine intake on platelet function and viscoelastic property of blood in volunteers. 
  • The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. 
  • The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. 
  • Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation. 
  • Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture. 
  • Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps? 
  • Two-state displacement by the kinesin-14 Ncd stalk. 
  • Using genetically encoded fluorescent biosensors to interrogate ovarian cancer metabolism. 
  • Visualizing cytoplasmic ATP in C. elegans larvae using PercevalHR. 
  • Vitamin E and total parenteral nutrition. 
  • What keeps a resting T cell alive? 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
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  Keywords of People

  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology