Subject Areas on Research
- 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
- A Bigger Look Into the "Therapeutic Window" of Platelet Reactivity to Adenosine Diphosphate.
- A kinesin motor in a force-producing conformation.
- A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase.
- A new method of representing drug-induced platelet inhibition: better description of time course, response variability, non-response, and heightened activity.
- A novel method to assess platelet inhibition by eptifibatide with thrombelastograph.
- ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films.
- Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.
- Adenine nucleotides of ischemic intestine do not reflect injury.
- Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events.
- Adenosine nucleotides and the regulation of GRP94-client protein interactions.
- Adenosine nucleotides in bile.
- Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
- Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase.
- Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism.
- An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.
- Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. The GUSTO-III Platelet Substudy.
- Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients.
- Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center.
- Assessment of the number of nucleotide binding sites on chloroplast coupling factor 1 by the continuous variation method.
- Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor.
- Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.
- Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study.
- Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
- Characterization of nucleotide binding sites on chloroplast coupling factor 1.
- Characterization of three-subunit chloroplast coupling factor.
- Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
- Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial).
- Clinical validation of AggreGuide A-100 ADP, a novel assay for assessing the antiplatelet effect of oral P2Y12 antagonists.
- Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding.
- Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity.
- Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
- Comparing Inverse Probability of Treatment Weighting and Instrumental Variable Methods for the Evaluation of Adenosine Diphosphate Receptor Inhibitors After Percutaneous Coronary Intervention.
- Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.
- Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding.
- Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.
- Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant.
- Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.
- Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.
- Differential and simultaneous adenosine di- and triphosphate binding by MutS.
- Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents.
- Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites.
- Direct effects of CO on cerebral energy metabolism in bloodless rats.
- Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.
- Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium.
- Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.
- Effects of hypoxia and toxicant exposure on adenylate energy charge and cytosolic ADP concentrations in abalone.
- Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy.
- Energy metabolism and in vivo cytochrome c oxidase redox relationships in hypoxic rat brain.
- Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase.
- Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.
- Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes?
- Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance': a rebuttal.
- Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis.
- Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1.
- Function of tightly bound nucleotides on membrane-bound chloroplast coupling factor.
- Further characterization of nucleotide binding sites on chloroplast coupling factor one.
- G-protein-coupled receptors as signaling targets for antiplatelet therapy.
- Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
- Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction.
- High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells.
- Homologous Recombination Repair Gene Variants and Outcomes Among Patients With Prostate Cancer Treated With Poly (ADP-ribose) Polymerase Inhibitors.
- Hostility and platelet reactivity in individuals without a history of cardiovascular disease events.
- Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.
- Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
- Immunity to thrombotic events is achievable if we stop the guessing game: is this the major hidden message from GRAVITAS?
- Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account.
- In vitro effects of recombinant activated factor VIIa (NovoSeven) on clopidogrel-induced platelet inhibition.
- Influence of CYP2C19*2 and *3 loss-of-function alleles on the pharmacodynamic effects of standard- and high-dose clopidogrel in East Asians undergoing percutaneous coronary intervention: the results of the ACCEL-DOUBLE-2N3 study.
- Interaction of nucleotides with chloroplast coupling factor 1.
- Interactions between nucleotide binding sites on chloroplast coupling factor during ATP hydrolysis.
- Kinesin motors as molecular machines.
- Kinetics of allosteric enzymes.
- Large conformational changes in a kinesin motor catalyzed by interaction with microtubules.
- Mechanical loading stimulates ecto-ATPase activity in human tendon cells.
- Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.
- Molecular strategies for the treatment of diabetes.
- Monitoring platelet inhibition during chronic oral platelet glycoprotein IIb/IIIa blockade: are we missing something?
- NAD+ modulates p53 DNA binding specificity and function.
- Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.
- Normal cardiac function in mice with supraphysiological cardiac creatine levels.
- Nucleotide interactions with the dicyclohexylcarbodiimide-sensitive adenosinetriphosphatase from spinach chloroplasts.
- Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism.
- Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.
- Pharmacodynamic effects of clopidogrel in pediatric cardiac patients: a comparative study of platelet aggregation response.
- Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine.
- Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients.
- Platelet inhibition by low-dose aspirin is not influenced by body mass or weight.
- Platelet reactivity to adenosine diphosphate and long-term ischemic event occurrence following percutaneous coronary intervention: a potential antiplatelet therapeutic target.
- Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish.
- Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria.
- Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass.
- Rapid double 8-nm steps by a kinesin mutant.
- Reversible uncoupling of oxidative phosphorylation at low oxygen tension.
- Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties.
- Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd.
- SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
- Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation.
- Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
- Steady state kinetics of soluble and membrane-bound mitochondrial ATPase.
- Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA.
- Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94.
- Structure of the human MutSalpha DNA lesion recognition complex.
- Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
- Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold.
- Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study.
- The CD28 signaling pathway regulates glucose metabolism.
- The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.
- The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.
- The association of cigarette smoking with enhanced platelet inhibition by clopidogrel.
- The bleeding diathesis in human glycogen storage disease type I: in vitro identification of a naturally occurring inhibitor of ristocetin-induced platelet aggregation.
- The difference between clopidogrel responsiveness and posttreatment platelet reactivity.
- The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients.
- The effects of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography.
- The influence of red wine or white wine intake on platelet function and viscoelastic property of blood in volunteers.
- The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting.
- The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.
- Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation.
- Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture.
- Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps?
- Two-state displacement by the kinesin-14 Ncd stalk.
- Using genetically encoded fluorescent biosensors to interrogate ovarian cancer metabolism.
- Visualizing cytoplasmic ATP in C. elegans larvae using PercevalHR.
- Vitamin E and total parenteral nutrition.
- What keeps a resting T cell alive?
- X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution.
Keywords of People
- O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology