Calcium-Transporting ATPases

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  Subject Areas on Research

  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. 
  • Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes. 
  • Binding stoichiometry and structural mapping of the epsilon polypeptide of chloroplast coupling factor 1. 
  • Biochemical and cytochemical comparison of surface membranes from normal and dystrophic chickens. 
  • Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells. 
  • Chloroplast coupling factor 1: dependence of rotational correlation time on polypeptide composition. 
  • Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Gene delivery approaches to heart failure treatment. 
  • Increased Ca2+ -ATPase activity associated with methylation of phospholipids in human erythrocytes. 
  • Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. 
  • Intracellular mediators of insulin action. 
  • Mechanism of calcium influx in endothelial cells: role of intracellular calcium. 
  • Myocardial myoglobin deficiency in various animal models of congestive heart failure. 
  • Myosin from human erythrocytes. 
  • Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Red blood cell and fibroblast membranes in Duchenne and myotonic muscular dystrophy. 
  • Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool. 
  • Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. 
  • Spermine. A regulator of mitochondrial calcium cycling. 
  • Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. 
  • The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. 
  • The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction. 
  • The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. 
  • Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. 
  • Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Juvvadi, Praveen Rao, Associate Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Duke Innovation & Entrepreneurship