Adenosine Triphosphate

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  Subject Areas on Research

  • 1990 ARRS Executive Council Award. Renal transplant rejection: diagnosis with 31P MR spectroscopy. 
  • 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. 
  • 31P NMR spectroscopy and polarographic combined study of erythrocytes treated with 5-fluorouracil: cardiotoxicity-related changes in ATP, 2,3-BPG, and O2 metabolism. 
  • A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. 
  • A KINETIC INVESTIGATION OF THE INTERACTION OF ADENOSINE-5'-TRIPHOSPHATE WITH DIVALENT METAL IONS. 
  • A calorimetric study of the interaction of ATP with rabbit muscle phosphofructokinase. 
  • A kinesin motor in a force-producing conformation. 
  • A mammalian activity required for the second step of pre-messenger RNA splicing. 
  • A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes. 
  • A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. 
  • A new structural state of myosin. 
  • A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. 
  • A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+. 
  • ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation. 
  • ATP-regulated activity of the plasmin-streptokinase complex: a novel mechanism involving phosphorylation of streptokinase. 
  • ATP-sensitive K+ channels in a plasma membrane H+-ATPase mutant of the yeast Saccharomyces cerevisiae. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Abnormalities in S-adenosylhomocysteine hydrolysis, ATP catabolism, and lymphoid differentiation in adenosine deaminase deficiency. 
  • Accelerated transmural gradients of energy compound metabolism resulting from left ventricular hypertrophy. 
  • Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. 
  • Activation of the plant mitochondrial alternative oxidase: insights from site-directed mutagenesis. 
  • Activity and activation of the granulocyte superoxide-generating system. 
  • Adenine nucleotides of ischemic intestine do not reflect injury. 
  • Adenosine A3 receptor stimulation attenuates postischemic dysfunction through KATP channels 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Adenosine nucleotides in bile. 
  • Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Adrenal medullary storage vesicles of the spontaneously hypertensive rat. 
  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • All-or-none secretion of adrenal medullary storage vesicle contents in the rat. 
  • Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes. 
  • Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. 
  • Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. 
  • Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. 
  • Altered metabolism in cancer. 
  • Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Amino acid sequence of the nucleotide binding region of chloroplast coupling factor 1. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract. 
  • An N-terminal truncation of the ncd motor protein supports diffusional movement of microtubules in motility assays. 
  • An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. 
  • An isolated perfused rat lung preparation. 
  • Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Anion modulation of the negative Bohr effect of haemoglobin from a primitive amphibian. 
  • Annulus cells release ATP in response to vibratory loading in vitro. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Assembly of pure tubulin in the absence of free GTP: effect of magnesium, glycerol, ATP, and the nonhydrolyzable GTP analogues. 
  • Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. 
  • Assessing heterogeneity in oligomeric AAA+ machines. 
  • Association of chronic congestive heart failure in humans with an intrinsic upregulation in skeletal muscle sarcoplasmic reticulum calcium ion adenosine triphosphatase activity. 
  • Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair. 
  • Bacterially synthesized vertebrate calmodulin is a specific substrate for ubiquitination. 
  • Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis. 
  • Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. 
  • Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. 
  • Binding of ADP and adenosine 5'-[beta, gamma-imido]triphosphate to insect flight muscle fibrils. 
  • Binding of amines to purified bovine adrenal medullary storage vesicle membranes. 
  • Biochemical and structural changes in cultured heart cells induced by metabolic inhibition. 
  • Biochemical changes in leukocytes in response to chemoattractants. 
  • Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. 
  • Boron-containing aptamers to ATP. 
  • Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. 
  • Brain and central haemodynamics and oxygenation during maximal exercise in humans. 
  • Breaking symmetry in multimeric ATPase motors. 
  • Ca2+ regulation of sperm axonemal motility. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. 
  • Can adenine nucleotides predict primary nonfunction of the human liver homograft? 
  • Can immune cell function assay identify patients at risk of infection or rejection? A meta-analysis. 
  • Cancer. A radical approach to treatment. 
  • Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione. 
  • Cardiac sarcoplasmic reticulum: chemical and electron microscope studies of calcium accumulation. 
  • Carrier detection in Duchenne muscular dystrophy. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Cell mechanics: dissecting the physical responses of cells to force. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Chaperones rescue luciferase folding by separating its domains. 
  • Characteristics of chronic left ventricular hypertrophy induced by subcoronary valvular aortic stenosis. I. Myocardial blood flow and metabolism. 
  • Characteristics of chronic left ventricular hypertrophy induced by subcoronary valvular aortic stenosis. II. Response to ischemia. 
  • Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells. 
  • Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique. 
  • Characterization of three-subunit chloroplast coupling factor. 
  • Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus. 
  • Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. 
  • Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. 
  • Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. 
  • Co-ordinated electron microscopy and X-ray studies of glycerinated insect flight muscle. I. X-ray diffraction monitoring during preparation for electron microscopy of muscle fibres fixed in rigor, in ATP and in AMPPNP. 
  • Co-ordinated electron microscopy and X-ray studies of glycerinated insect flight muscle. II. Electron microscopy and image reconstruction of muscle fibres fixed in rigor, in ATP and in AMPPNP. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. 
  • Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I. 
  • Correlation of mitochondrial function and ischemic contracture. 
  • Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle. 
  • Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. 
  • Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystallization and preliminary X-ray analysis of the ATPase domain of the σ(54)-dependent transcription activator NtrC1 from Aquifex aeolicus bound to the ATP analog ADP-BeFx. 
  • Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). 
  • Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18. 
  • Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. 
  • Depletion of myocardial high energy phosphates by induction of ventricular fibrillation prior to cardioplegic arrest. 
  • Depressed high-energy phosphate content in hypertrophied ventricles of animal and man: the biologic basis for increased sensitivity to ischemic injury. 
  • Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Differentiation of U937 cells enables a phospholipase D-dependent pathway of cytosolic phospholipase A2 activation. 
  • Direct effects of CO on cerebral energy metabolism in bloodless rats. 
  • Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail. 
  • Discovery of novel targets of quinoline drugs in the human purine binding proteome. 
  • Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. 
  • Drug-resistant effect of adenine nucleotides and magnesium on catecholamine efflux from isolated adrenal medullary storage vesicles. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells. 
  • Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. 
  • Effect of polyethylene glycol-modified adenosine deaminase (PEG-ADA) therapy in two ADA-deficient children: measurement of erythrocyte deoxyadenosine triphosphate as a useful tool. 
  • Effect of the shape and configuration of smooth muscle cells on the diffusion of ATP through the arterial wall. 
  • Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. 
  • Effects of continuous-wave, pulsed, and sinusoidal-amplitude-modulated microwaves on brain energy metabolism. 
  • Effects of delay in administration of potassium cardioplegia to the isolated rat heart. 
  • Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Effects of sustained ventricular fibrillation on nonhypertrophied heart. 
  • Electron tomography of insect flight muscle in rigor and AMPPNP at 23 degrees C. 
  • Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. 
  • Energy metabolism and in vivo cytochrome c oxidase redox relationships in hypoxic rat brain. 
  • Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion. 
  • Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. 
  • Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ ATPase for remodeling bacterial RNA polymerase. 
  • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. 
  • Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. 
  • Escherichia coli phage T4 topoisomerase. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Force generation by kinesin and myosin cytoskeletal motor proteins. 
  • From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. 
  • Function of tightly bound nucleotides on membrane-bound chloroplast coupling factor. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Further characterization of nucleotide binding sites on chloroplast coupling factor one. 
  • Genetic approaches to molecular motors. 
  • Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Group I intron self-splicing with adenosine: evidence for a single nucleoside-binding site. 
  • HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. 
  • Hemoglobin of the electric Atlantic torpedo, Torpedo nobiliana: a cooperative hemoglobin without Bohr effects. 
  • Hemoglobins of Boa constrictor amarali. 
  • Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy. 
  • Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. 
  • Histologic and biochemical correlates of left ventricular chamber dynamics in man. 
  • How does protein architecture facilitate the transduction of ATP chemical-bond energy into mechanical work? The cases of nitrogenase and ATP binding-cassette proteins. 
  • Human in vivo phosphate metabolite imaging with 31P NMR. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. 
  • Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in hog pial membranes. 
  • Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. 
  • Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Imaging molecular pathways: reporter genes. 
  • Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. 
  • Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. 
  • Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. 
  • Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation. 
  • Implications of sustained elevation in extracellular ATP in retina following chronic ocular hypertension. 
  • Improved tolerance to ischemia in hypertrophied myocardium by preischemic enhancement of adenosine triphosphate. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase. 
  • Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3. 
  • Induced changes in orientation of the cross-bridges of glycerinated insect flight muscle. 
  • Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. 
  • Influence of allosteric ligands on the activity and aggregation of rabbit muscle phosphofructokinase. 
  • Inhibition of the proton-translocating adenosine triphosphatase from chromatophores of photosynthetic bacteria by free bivalent cations and adenosine triphosphate [proceedings]. 
  • Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. 
  • Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent. 
  • Interaction of nucleotides with chloroplast coupling factor 1. 
  • Interactions between nucleotide binding sites on chloroplast coupling factor during ATP hydrolysis. 
  • Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. 
  • Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. 
  • Investigation of nucleotide binding sites on chloroplast coupling factor 1 with 3'O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. 
  • Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. 
  • Irreversible stimulation of adenylate cyclase activity of fat cell membranes of phosphoramidate and phosphonate analogs of GTP. 
  • Is myosin a "back door" enzyme? 
  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. 
  • Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio). 
  • Kinesin motors as molecular machines. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Kinetics of allosteric enzymes. 
  • Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export. 
  • MECHANISM OF ENZYME CATALYSIS. 
  • Maturation of the adrenal medulla. I. Uptake and storage of amines in isolated storage vesicles of the rat. 
  • Maturation of the adrenal medulla. II. Content and properties of catecholamine storage vesicles of the rat. 
  • Mechanism for catalysis and regulation of adenosine 5'-triphosphate hydrolysis by chloroplast coupling factor 1. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. 
  • Mechanisms of ATP release, the enabling step in purinergic dynamics. 
  • Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion. 
  • Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3. 
  • Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. 
  • Membrane mechanical properties of ATP-depleted human erythrocytes. 
  • Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. 
  • Metabolic coupling factors in pancreatic beta-cell signal transduction. 
  • Metabolic dependence of red cell shape: observations with the scanning electron microscope. 
  • Metabolic deterioration during global ischemia as a function of time in the intact normal dog heart. 
  • Metabolic flux and the regulation of mammalian cell growth. 
  • Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. 
  • Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. 
  • Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis. 
  • Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C. 
  • Metformin reverses fatty liver disease in obese, leptin-deficient mice. 
  • Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development. 
  • Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat. 
  • Microwave effects on energy metabolism of rat brain. 
  • Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. 
  • Modeling glucose metabolism and lactate production in the kidney. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • Molecular strategies for the treatment of diabetes. 
  • Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. 
  • Multiple-particle tracking and two-point microrheology in cells. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Myocardial adenosine triphosphate levels during early sepsis. 
  • Myocardial beta-adrenergic receptor function and high-energy phosphates in brain death--related cardiac dysfunction. 
  • Myocardial tolerance to mechanical actuation is affected by biomaterial characteristics. 
  • Myosin-actin motors: the partnership goes atomic. 
  • Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy. 
  • Nucleotide interactions with the dicyclohexylcarbodiimide-sensitive adenosinetriphosphatase from spinach chloroplasts. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Nucleotide-induced asymmetry within ATPase activator ring drives σ54-RNAP interaction and ATP hydrolysis. 
  • O2 dependence of in vivo brain cytochrome redox responses and energy metabolism in bloodless rats. 
  • OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding. 
  • Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. 
  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. 
  • Ontogeny of (--)-[3H]norepinephrine uptake properties of synaptic storage vesicles of rat brain. 
  • Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. 
  • Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 
  • Phosphorus 31 magnetic resonance spectroscopy of human placenta and quantitation with perchloric acid extracts. 
  • Phosphorus 31 magnetic resonance spectroscopy of perifused human placental villi under varying oxygen concentrations. 
  • Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK. 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Poly (A) sequences of vaccinia virus messenger RNA: nature, mode of addition and function during translation in vitra and in vivo. 
  • Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria. 
  • Preservation of myocardial high energy phosphates during cardioplegic arrest with nifedipine. 
  • Preservation of myocardial high-energy phosphates during cardioplegic arrest with nifedipine. 
  • Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia. 
  • Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry. 
  • Probing the DNA sequence specificity of Escherichia coli RECA protein. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Protein biosynthesis in the testis. 3. Dual effect of glucose. 
  • Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain. 
  • Protein kinase C activates the renal apical membrane Na+/H+ exchanger. 
  • Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes. 
  • Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. 
  • Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys. 
  • Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel. 
  • Purine nucleotides contribute to pulmonary vasodilation caused by birth-related stimuli in the ovine fetus. 
  • Purinergic signalling underlies transforming growth factor-β-mediated bladder afferent nerve hyperexcitability. 
  • Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. 
  • Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration. 
  • Quantitative measurement of cell adhesion using centrifugal force. 
  • Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein. 
  • Recovery of rat adrenal amine stores after insulin administration. 
  • Reduction in pulmonary and hepatic respiratory cytochrome contents by fly ash inhalation in rats. 
  • Regulation of DNA replication in S phase nuclei by ATP and ADP pools. 
  • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. 
  • Regulation of cholecystokinin secretion by ATP-sensitive potassium channels. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers. 
  • Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. 
  • Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II. 
  • Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running. 
  • Relationship of tri-O-cresyl phosphate-induced delayed neurotoxicity to enhancement of in vitro phosphorylation of hen brain and spinal cord proteins. 
  • Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles. 
  • Relaxation spectra of adenosine triphosphate-creatine phosphotransferase. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog. 
  • Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration. 
  • Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. 
  • Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs. 
  • Reserpine-like effects of harmine on isolated adrenal medullary vesicles. 
  • Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion. 
  • Reversing the Warburg effect as a treatment for glioblastoma. 
  • Rewiring of glycolysis in cancer cell metabolism. 
  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. 
  • Ribose-enhanced myocardial recovery following ischemia in the isolated working rat heart. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. 
  • SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding. 
  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. 
  • SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. 
  • SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. 
  • SU5416 delays wound healing through inhibition of TGF-beta 1 activation. 
  • SUMO2/3 conjugation is an endogenous neuroprotective mechanism. 
  • Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. 
  • Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans. 
  • Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. 
  • Simple step gradient elution of the major high-energy compounds and their catabolites in cardiac muscle using high-performance liquid chromatography. 
  • Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. 
  • Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men. 
  • Sonomicrometric determination of ischemic contracture of the left ventricle. 
  • Spectrophotometry of b-type cytochromes in rat brain in vivo and in vitro. 
  • Spectrophotometry of b-type cytochromes in rat brain in vivo and in vitro. 
  • Spermine. A regulator of mitochondrial calcium cycling. 
  • StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions. 
  • Steady state kinetic studies of purified yeast plasma membrane proton-translocating ATPase. 
  • Steady state kinetics of ATP synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
  • Steady-state ATP synthesis by bacteriorhodopsin and chloroplast coupling factor co-reconstituted into asolectin vesicles. 
  • Steady-state kinetic study of rabbit muscle phosphofructokinase. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport. 
  • Structural mapping of chloroplast coupling factor. 
  • Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation. 
  • Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94. 
  • Structure and activities of Escherichia coli DNA gyrase. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Studies of the phosphoenzyme intermediate of the yeast plasma membrane proton-translocating ATPase. 
  • Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro. 
  • Study of the interaction of adenylyl imidodiphosphate with rabbit muscle phosphofructokinase. 
  • Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. 
  • Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. 
  • Suspension of medullary thick ascending limb tubules from the rabbit kidney. 
  • Synaptic vesicles isolated from rat heart: l-[3H]norepinephrine uptake properties. 
  • Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents. 
  • Synthesis and properties of novel triphosphate analogues: ribonucleoside and deoxyribonucleoside (alpha-P-borano, alpha-P-thio)triphosphates. 
  • Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. 
  • Targeting cell surface F1F0 ATP synthase in cancer therapy. 
  • Temperature-jump study of the interaction of rabbit muscle phosphofructokinase with adenylyl imidodiphosphate and adenosine 5'-triphosphate. 
  • The ATP binding site of the yeast plasma membrane proton-translocating ATPase. 
  • The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein. 
  • The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link? 
  • The Survival of Cone Photoreceptors in Retinitis Pigmentosa. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The Warburg Effect: How Does it Benefit Cancer Cells? 
  • The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. 
  • The cell division protein MinD from Pseudomonas aeruginosa dominates the assembly of the MinC-MinD copolymers. 
  • The consensus mechanics of cultured mammalian cells 
  • The differential effects of 200, 591, and 2,450 MHz radiation on rat brain energy metabolism. 
  • The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro. 
  • The effects of hyperthermia and hyperthermia plus microwaves on rat brain energy metabolism. 
  • The effects of tempol on cyclophosphamide-induced oxidative stress in rat micturition reflexes. 
  • The effects of tri-o-cresyl phosphate and metabolites on rat Sertoli cell function in primary culture. 
  • The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. 
  • The fate of inorganic phosphate and pH in regional myocardial ischemia and infarction: a noninvasive 31P NMR study. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. 
  • The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs. 
  • The safety of induced ventricular fibrillation during cardiopulmonary bypass in nonhypertrophied hearts. 
  • The structure of insect flight muscle in the presence of AMPPNP. 
  • The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans. 
  • Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy. 
  • Thermal transition in the human erythrocyte membrane: effect on elasticity. 
  • Three-dimensional structure of nucleotide-bearing crossbridges in situ: oblique section reconstruction of insect flight muscle in AMPPNP at 23 degrees C. 
  • Time limits for submersion of canine left ventricular biopsies in cold isopentane. 
  • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. 
  • Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. 
  • Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics. 
  • Triphenyl phosphite-induced ultrastructural changes in bovine adrenomedullary chromaffin cells. 
  • Two attached non-rigor crossbridge forms in insect flight muscle. 
  • Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins. 
  • Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • What keeps a resting T cell alive? 
  • Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. 
  • X-ray diffraction and electron microscopy from Lethocerus flight muscle partially relaxed by adenylylimidodiphosphate and ethylene glycol. 
  • Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. 
  • [Relaxation spectrometric studies of fast reactions of ATP in aqueous solution]. 
  • cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • pH dependence of adenosine 5'-triphosphate synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
• 

  Keywords of People

  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Hirschey, Matthew, Associate Professor in Medicine, Pharmacology & Cancer Biology
  • Schwartz-Bloom, Rochelle D., Professor in Pharmacology & Cancer Biology, Duke Science & Society
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Zhang, Zhiquan, Assistant Professor in Anesthesiology, Anesthesiology