Adenylate Cyclase

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  Subject Areas on Research

  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. 
  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. 
  • 8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. 
  • A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density. 
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. 
  • A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation. 
  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. 
  • A role for Ni in the hormonal stimulation of adenylate cyclase. 
  • A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. 
  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. 
  • ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. 
  • ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. 
  • Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. 
  • Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. 
  • Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization. 
  • Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group. 
  • Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin. 
  • Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. 
  • Adenylate cyclase coupled beta-adrenergic receptors: biochemical mechanisms of desensitization. 
  • Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. 
  • Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. 
  • Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. 
  • Adenylyl cyclase expression and modulation of cAMP in rat taste cells. 
  • Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. 
  • Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects. 
  • Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. 
  • Adrenergic receptors: molecular mechanisms of clinically relevant regulation. 
  • Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors. 
  • Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase. 
  • Agonist-induced increase in apparent beta-adrenergic receptor size. 
  • Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase. 
  • Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. 
  • Agonist-promoted high affinity state of the beta-adrenergic receptor in human neutrophils: modulation by corticosteroids. 
  • Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets. 
  • Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets. 
  • Alfred Goodman Gilman (1941-2015). 
  • Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism. 
  • Altered development of basal and forskolin-stimulated adenylate cyclase activity in brain regions of rats exposed to nicotine prenatally. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. 
  • Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat. 
  • Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. 
  • Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. 
  • Are developing beta-adrenoceptors able to desensitize? Acute and chronic effects of beta-agonists in neonatal heart and liver. 
  • Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation. 
  • Atypical regulation of hepatic adenylyl cyclase and adrenergic receptors during a critical developmental period: agonists evoke supersensitivity accompanied by failure of receptor down-regulation. 
  • Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins. 
  • Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. 
  • Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation. 
  • Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. 
  • Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. 
  • Beta-adrenergic receptors: evidence for negative cooperativity. 
  • Beta-adrenergic receptors: regulatory role of agonists. 
  • Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. 
  • Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization. 
  • Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. 
  • Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline. 
  • Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. 
  • Biochemical and cytochemical comparison of surface membranes from normal and dystrophic chickens. 
  • Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. 
  • Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. 
  • Biochemical mechanisms of hormone receptor-effector coupling. Introduction. 
  • Biological activity of agarose-immobilized catecholamines. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • Cardiac adrenergic receptors. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of nucleotides. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids. 
  • Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. 
  • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. 
  • Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. 
  • Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase. 
  • Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. 
  • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. 
  • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. 
  • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. 
  • Central regulation of photosensitive membrane turnover in the lateral eye of Limulus, II: octopamine acts via adenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding. 
  • Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. 
  • Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. 
  • Cholera toxin and cell growth: role of membrane gangliosides. 
  • Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. 
  • Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Clinical physiology of adrenergic receptor regulation. 
  • Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report. 
  • Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Comparison of human growth hormone binding to rat liver plasma and Golgi membranes. 
  • Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. 
  • Control of adenylate cyclase activity in developing rat heart and liver: effects of prenatal exposure to terbutaline or dexamethasone. 
  • Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes. 
  • Corticosteroid-induced differential regulation of beta-adrenergic receptors in circulating human polymorphonuclear leukocytes and mononuclear leukocytes. 
  • Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. 
  • Coupled events in the early biochemical actions of FSH on the Sertoli cells of the testis. 
  • Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. 
  • Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. 
  • Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility. 
  • Decreased spontaneous motor activity parallels reserpine-induced supersensitivity of catecholamine-responsive rat cerebral cortex adenylate cyclase. 
  • Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism. 
  • Defining G protein beta gamma specificity for effector recognition. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. 
  • Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. 
  • Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death. 
  • Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. 
  • Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. 
  • Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. 
  • Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. 
  • Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. 
  • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. 
  • Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target? 
  • Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. 
  • Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. 
  • Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses. 
  • Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion. 
  • Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? 
  • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. 
  • Dopamine-sensitive adenylate cyclase: antagonism by impiramine and its analogues. 
  • Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways. 
  • Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. 
  • Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. 
  • Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. 
  • Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. 
  • Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. 
  • Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. 
  • Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and on beta-adrenergic receptors. 
  • Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. 
  • Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. 
  • Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. 
  • Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system. 
  • Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with beta-adrenergic receptor antagonists. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. 
  • Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats. 
  • Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. 
  • Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum. 
  • Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. 
  • Evidence that forskolin binds to the glucose transporter of human erythrocytes. 
  • Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. 
  • Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. 
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). 
  • Factors affecting Sertoli cell function in the testis. 
  • Fetal dexamethasone exposure accelerates development of renal function: relationship to dose, cell differentiation and growth inhibition. 
  • Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. 
  • Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • Functional integrity of desensitized beta-adrenergic receptors. 
  • Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. 
  • G protein involvement in receptor-effector coupling. 
  • G proteins. The subunit story thickens. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • G-protein-linked signaling pathways mediate development in Dictyostelium. 
  • Galphaz negatively regulates insulin secretion and glucose clearance. 
  • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. 
  • Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. 
  • Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization? 
  • Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure. 
  • Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity. 
  • Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine. 
  • Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. 
  • Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors. 
  • Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni. 
  • High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics. 
  • Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol. 
  • Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues. 
  • Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. 
  • Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Hormone receptor complexes and their modulation of membrane function. 
  • Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition. 
  • Hormones, receptors, and cyclic AMP: their role in target cell refractoriness. 
  • How Gsalpha activates adenylyl cyclase. 
  • Human platelet adenylate cyclase: delineation of distinct stimulatory and inhibitory guanine nucleotide regulatory pathways. 
  • Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes. 
  • Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in hog pial membranes. 
  • Identification and regulation of alpha- and beta-adrenergic receptors. 
  • Identification and regulation of beta-adrenergic receptors. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding. 
  • Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. 
  • Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. 
  • Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. 
  • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. 
  • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. 
  • Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. 
  • In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids. 
  • In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones. 
  • In vivo effect of human growth hormone on hepatic adenylate cyclase activity. 
  • In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. 
  • Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. 
  • Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8. 
  • Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. 
  • Inhibitory effect of ristocetin and factor VIII/von Willebrand factor protein on human platelet adenylate cyclase activity. 
  • Interactions of agonists with platelet alpha 2-adrenergic receptors. 
  • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. 
  • Intracellular mediators of insulin action. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Irreversible activation of adenylate cyclase of toad erythrocyte plasma membrane by 5'-guanylylimidodiphosphate. 
  • Irreversible stimulation of adenylate cyclase activity of fat cell membranes of phosphoramidate and phosphonate analogs of GTP. 
  • Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolated hormone receptors: physiologic and clinical implications. 
  • Kinetics of irreversible activation of adenylate cyclase of fat cell membranes by phosphonium and phosphoramidate analogs of gtp1. 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. 
  • Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. 
  • Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. 
  • Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors. 
  • Mechanism of action of Vibrio cholerae enterotoxin. Effects on adenylate cyclase of toad and rat erythrocyte plasma membranes. 
  • Mechanism of action of cholera toxin and the mobile receptor theory of hormone receptor-adenylate cyclase interactions. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. Relations to the mode of activation by hormones. 
  • Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. 
  • Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. 
  • Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts. 
  • Metoprolol and coronary artery bypass grafting surgery: does intraoperative metoprolol attenuate acute beta-adrenergic receptor desensitization during cardiac surgery? 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. 
  • Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. 
  • Molecular and regulatory properties of adrenergic receptors. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors. 
  • Molecular mechanisms of beta-adrenergic receptor desensitization. 
  • Molecular mechanisms of beta-adrenergic receptor desensitization. 
  • Molecular mechanisms of coupling in hormone receptor-adenylate cyclase systems. 
  • Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. 
  • Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. 
  • Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes. 
  • Multiple effects of guanine nucleotides on human platelet adenylated cyclase. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. 
  • Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. 
  • Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired formation of high-affinity agonist-receptor complexes. 
  • Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. 
  • Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. 
  • Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood. 
  • Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. 
  • Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum. 
  • Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. 
  • Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. 
  • Ontogeny of beta-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. 
  • Overexpression of alpha 2-adrenergic receptors in fetal rat heart: receptors in search of a function. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. 
  • PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. 
  • Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. 
  • Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. 
  • Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung. 
  • Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Pharmacological activity of nitroxide analogues of dichloroisoproterenol and propranolol. 
  • Pharmacological characterizations of adrenergic receptors in human adipocytes. 
  • Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. 
  • Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. 
  • Phospholipid methylation: a possible mechanism of signal transduction across biomembranes. 
  • Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors. 
  • Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. 
  • Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. 
  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. 
  • Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. 
  • Physiological receptors as physicochemical entities. 
  • Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. 
  • Plasma membrane receptors. 
  • Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. 
  • Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. 
  • Prenatal terbutaline treatment: tissue-selective dissociation of perinatal changes in beta-adrenergic receptor binding from regulation of adenylate cyclase activity. 
  • Preparation of inverted plasma membrane vesicles from isolated adipocytes. 
  • Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 
  • Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans. 
  • Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure. 
  • Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure. 
  • Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323. 
  • Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. 
  • Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. 
  • Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. 
  • Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. 
  • Reconstitution of the beta-adrenergic receptor. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors. 
  • Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. 
  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. 
  • Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes. 
  • Regulation of beta-adrenergic receptor-mediated processes in fetal rat lung: selective desensitization caused by chronic terbutaline exposure. 
  • Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of beta-adrenergic receptors by steroid hormones. 
  • Regulation of fetal cardiac and hepatic beta-adrenoceptors and adenylyl cyclase signaling: terbutaline effects. 
  • Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. 
  • Regulation of postnatal beta-adrenergic receptor/adenylate cyclase development by prenatal agonist stimulation and steroids: alterations in rat kidney and lung after exposure to terbutaline or dexamethasone. 
  • Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes. 
  • Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. 
  • Regulation of type II adenylyl cyclase mRNA in rabbit skeletal muscle by chronic motor nerve pacing. 
  • Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. 
  • Rodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine. 
  • Role of G proteins in transmembrane signaling. 
  • Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. 
  • Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants. 
  • Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression. 
  • Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. 
  • Role of thyroid status in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase, ornithine decarboxylase and c-fos protooncogene expression. 
  • Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization. 
  • Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. 
  • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. 
  • Simple model for hormone-activated adenylate cyclase systems. 
  • Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. 
  • Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training. 
  • Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. 
  • Species differences in alpha 2-adrenergic regulation of platelet adenylate cyclase. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. 
  • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors. 
  • Structure and function of beta-adrenergic receptors: regulation at the molecular level. 
  • Structure and function of cholera toxin and hormone receptors. 
  • Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. 
  • Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. 
  • Studies of dopamine pharmacology in molluscs. 
  • Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. 
  • Suspension of medullary thick ascending limb tubules from the rabbit kidney. 
  • Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Techniques for the study of the biochemical basis of drug action. 
  • Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors. 
  • The Gordon Wilson lecture. Adrenergic receptors: regulation at the biochemical, physiological and clinical levels. 
  • The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. 
  • The adrenergic receptors. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The beta-adrenergic receptor. 
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. 
  • The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae. 
  • The impact of aging on adrenergic receptor function: clinical and biochemical aspects. 
  • The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. 
  • The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. 
  • The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • Thyroid hormone differentially regulates development of beta-adrenergic receptors, adenylate cyclase and ornithine decarboxylase in rat heart and kidney. 
  • Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: effects of propylthiouracil-induced perinatal hypothyroidism. 
  • Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. 
  • Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. 
  • Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. 
  • Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. 
  • Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. 
  • beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. 
  • beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. 
  • beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling. 
  • beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology