Administration, Inhalation

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  Subject Areas on Research

  • "Low-level" carbon monoxide administration may carry risk. 
  • A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups. 
  • A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension. 
  • A programmable smoke delivery device for PET imaging with cigarettes containing 11C-nicotine. 
  • A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation. 
  • A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children. 
  • Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. 
  • Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. 
  • Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. 
  • Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy. 
  • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. 
  • Adjunct Therapies for Refractory Status Asthmaticus in Children. 
  • Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis. 
  • Aerosolized antifungal prophylaxis: the winds of change? 
  • Aerosolized atropine sulfate: influence of inhalation pattern on effective blockade of vagal airway tone. 
  • Aerosolized ribavirin in the treatment of patients with respiratory syncytial virus disease. 
  • Aerosolized ribavirin: the most expensive drug for pneumonia. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Airway sensory replacement combined with nicotine replacement for smoking cessation. A randomized, placebo-controlled trial using a citric acid inhaler. 
  • Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Alveolar type II cell responses to chronic inhalation of chrysotile asbestos in rats. 
  • An Asthma Protocol Improved Adherence to Evidence-Based Guidelines for Pediatric Subjects With Status Asthmaticus in the Emergency Department. 
  • An appraisal of pharmacoeconomic evidence of maintenance therapy for COPD. 
  • Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial. 
  • Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine. 
  • Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis. 
  • Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis. 
  • Balancing the benefits and risks of inhaled long-acting beta-agonists--the influence of values. 
  • Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • CD14 is an essential mediator of LPS-induced airway disease. 
  • Candida pneumonia in a term infant after prolonged use of inhaled corticosteroids for bronchopulmonary dysplasia (BPD). 
  • Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents. 
  • Carbon disulfide inhalation increases Ca2+/calmodulin-dependent kinase phosphorylation of cytoskeletal proteins in the rat central nervous system. 
  • Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. 
  • Carcinogenicity of inhaled benzene in CBA mice. 
  • Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. 
  • Central nervous system distribution of inhaled toluene. 
  • Cerebral vasodilation and vasoconstriction associated with acute anxiety. 
  • Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis. 
  • Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. 
  • Chronic inhalation study of fiber glass and amosite asbestos in hamsters: twelve-month preliminary results. 
  • Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. 
  • Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. 
  • Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. 
  • Comparative study of extended release albuterol sulfate and long-acting inhaled salmeterol xinafoate in the treatment of nocturnal asthma. 
  • Comparison of inhaled isopropyl alcohol and intravenous ondansetron for treatment of postoperative nausea. 
  • Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. 
  • Comparison of systemic and mucosal vaccination: impact on intravenous and rectal SIV challenge. 
  • Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Consensus summary of aerosolized antimicrobial agents: application of guideline criteria. Insights from the Society of Infectious Diseases Pharmacists. 
  • Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. 
  • Corticosteroid Therapy During Acute Bronchiolitis in Patients Who Later Develop Asthma. 
  • Cystic fibrosis pulmonary guidelines: pulmonary complications: hemoptysis and pneumothorax. 
  • Daily versus as-needed corticosteroids for mild persistent asthma. 
  • Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. 
  • Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. 
  • Dispensing home nebulizers for acute wheezing from the hospital is cost-effective. 
  • Does improved oxygenation really imply increased benefit? 
  • Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. 
  • Double-ring esophageal sign: pathognomonic for esophageal lipomatosis. 
  • Early inhaled nitric oxide therapy in premature newborns with respiratory failure. 
  • Early management of acute severe asthma. 
  • Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. 
  • Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. 
  • Effect of lipopolysaccharide administration on the number, phenotype and content of nuclear molecules in blood microparticles of normal human subjects. 
  • Effect of nitrous oxide on cerebral blood velocity while reclining and standing. 
  • Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. 
  • Effects of immobilization restraint on Syrian golden hamsters. 
  • Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. 
  • Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. 
  • Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. 
  • Efficacy of esomeprazole for treatment of poorly controlled asthma. 
  • Efficacy of inhaled nitric oxide in preterm neonates. 
  • Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation. 
  • Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin. 
  • Endobronchial injection of botulinum toxin for the reduction of bronchial hyperreactivity induced by methacholine inhalation in dogs. 
  • Eosinophilic and Noneosinophilic Asthma. 
  • Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. 
  • Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin. 
  • Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. 
  • Fibrinolysis in LPS-induced chronic airway disease. 
  • Fibroproliferation in LPS-induced airway remodeling and bleomycin-induced fibrosis share common patterns of gene expression. 
  • Fibrous glass and cancer. 
  • Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant. 
  • Formaldehyde concentrations in the blood of rhesus monkeys after inhalation exposure. 
  • Gasoline sniffing multifocal neuropathy. 
  • Genes of innate immunity and the biological response to inhaled ozone. 
  • Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. 
  • Heliox administration in the pediatric intensive care unit: an evidence-based review. 
  • High prevalence of substance use disorders among adolescents who use marijuana and inhalants. 
  • Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. 
  • Impact of Age and Sex on Response to Asthma Therapy. 
  • Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug. 
  • In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency. 
  • In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols. 
  • In vivo exposure to nitrogen dioxide (NO2) induces a decrease in calcitonin gene-related peptide (CGRP) and tachykinin immunoreactivity in guinea-pig peripheral airways. 
  • Individualized therapy for persistent asthma in young children. 
  • Induction of cytochrome P450 isozymes by simultaneous inhalation exposure of hens to n-hexane and methyl iso-butyl ketone (MiBK). 
  • Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. 
  • Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia. 
  • Infectious diseases of the upper respiratory tract: implications for toxicology studies. 
  • Inhalant abuse and dependence among adolescents in the United States. 
  • Inhalant use and disorders among adults in the United States. 
  • Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. 
  • Inhalation with Tobramycin to improve healing of tracheobronchial reconstruction. 
  • Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. 
  • Inhaled Nitric Oxide (iNO) and Inhaled Epoprostenol (iPGI2) Use in Cardiothoracic Surgical Patients: Is there Sufficient Evidence for Evidence-Based Recommendations? 
  • Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. 
  • Inhaled Umeclidinium in COPD Patients: A Review and Meta-Analysis. 
  • Inhaled anti-inflammatory pharmacotherapy and subsequent hospitalizations and emergency department visits among patients with asthma in the Texas Medicaid program. 
  • Inhaled azithromycin therapy. 
  • Inhaled corticosteroids in obstructive airway disease. 
  • Inhaled epoprostenol during one-lung ventilation. 
  • Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants. 
  • Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. 
  • Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. 
  • Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. 
  • Inhaled nitric oxide after left ventricular assist device implantation: a prospective, randomized, double-blind, multicenter, placebo-controlled trial. 
  • Inhaled nitric oxide results in deteriorating hemodynamics when administered during cardiopulmonary bypass in neonatal swine. 
  • Inhaled nitric oxide selectively dilates pulmonary vasculature in adult patients with pulmonary hypertension, irrespective of etiology. 
  • Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. 
  • Inhaled short-acting beta2-agonists versus ipratropium for acute exacerbations of chronic obstructive pulmonary disease. 
  • Inhaled steroids as prophylaxis for delayed pulmonary toxicity syndrome in breast cancer patients undergoing high-dose chemotherapy and autologous stem cell transplantation. 
  • Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas. 
  • Initial characterization of micafungin pulmonary delivery via two different nebulizers and multivariate data analysis of aerosol mass distribution profiles. 
  • Insulin analogues: new therapies for type 2 diabetes mellitus. 
  • Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. 
  • Intracranial and extracranial blood flow during acute anxiety. 
  • Intraoperative use of inhaled PGI(2) for acute pulmonary hypertension and right ventricular failure. 
  • Intratracheal catheters as drug delivery systems. 
  • Is inhalant use a risk factor for heroin and injection drug use among adolescents in the United States? 
  • LPS binding protein is important in the airway response to inhaled endotoxin. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. 
  • Long-acting β2-agonist step-off in patients with controlled asthma. 
  • Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice. 
  • Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. 
  • Low levels of nitric oxide and carbon monoxide in alpha 1-antitrypsin deficiency. 
  • Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. 
  • Management Practice and Mortality for Infants with Congenital Diaphragmatic Hernia. 
  • Mechanical ventilation strategies in the management of congenital diaphragmatic hernia. 
  • Medical services and prescription use for asthma and factors that predict inhaled corticosteroid use among African-American children covered by Medicaid. 
  • Metabolic products of [2-(13) C]ethanol in the rat brain after chronic ethanol exposure. 
  • Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. 
  • Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis. 
  • Nebulized prostacyclin for pulmonary hypertension: a step in the right direction. 
  • Nebulizer delivery of micafungin aerosols. 
  • Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. 
  • PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. 
  • Pharmacokinetic modeling of the lung burden from repeated inhalation of nickel aerosols. 
  • Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. 
  • Pharmacotherapy of severe asthma. 
  • Physician-targeted program on inhaled therapy for childhood asthma. 
  • Pleural dosimetry and pathobiological responses in rats and hamsters exposed subchronically to MMVF 10a fiberglass. 
  • Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. 
  • Preferences and Stated Adherence for Antibiotic Treatment of Cystic Fibrosis Pseudomonas Infections. 
  • Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery. 
  • Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network. 
  • Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols. 
  • Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care. 
  • Psychiatric disorders in inhalant users: results from The National Epidemiologic Survey on Alcohol and Related Conditions. 
  • Pulmonary Delivery of Therapeutic and Diagnostic Gases. 
  • Pulmonary and pleural leukocytes from F344 rats produce elevated levels of fibronectin following inhalation of refractory ceramic fibers. 
  • Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. I. Quantitation of lung and pleural fiber burdens. 
  • Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. II. Pathobiologic responses. 
  • Pulmonary fibrogenesis after three consecutive inhalation exposures to chrysotile asbestos. 
  • Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. 
  • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. 
  • Quantifying asthma patient preferences for onset of effect of combination inhaled corticosteroids and long-acting beta2-agonist maintenance medications. 
  • Quantifying the importance of inhaler attributes corresponding to items in the patient satisfaction and preference questionnaire in patients using Combivent Respimat. 
  • Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine. 
  • Quantitative models of the dose-response and time course of inhalational anthrax in humans. 
  • Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. 
  • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. 
  • Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. 
  • Reduction in pulmonary and hepatic respiratory cytochrome contents by fly ash inhalation in rats. 
  • Regional cerebral blood flow changes associated with amyl nitrite inhalation. 
  • Respiratory care year in review 2010: part 2. Invasive mechanical ventilation, noninvasive ventilation, pediatric mechanical ventilation, aerosol therapy. 
  • Respiratory controversies in the critical care setting. Conference summary. 
  • Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis? 
  • Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition. 
  • Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV. 
  • S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction. 
  • S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. 
  • Safety and Tolerability of High-dose Inhaled Treprostinil in Pulmonary Hypertension. 
  • Safety of incremental inhaled lipopolysaccharide challenge in humans. 
  • Significant variability in response to inhaled corticosteroids for persistent asthma. 
  • Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. 
  • Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. 
  • Standardization of the single-breath diffusing capacity in a multicenter clinical trial. 
  • Subchronic endotoxin inhalation causes persistent airway disease. 
  • Systemic effect comparisons of six inhaled corticosteroid preparations. 
  • TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. 
  • Technosphere insulin: inhaled prandial insulin. 
  • The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. 
  • The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The effects of hyperoxic and hypercarbic gases on tumour blood flow. 
  • The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. 
  • The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • Therapeutic effect of infused Fluosol-DA/carbogen with ephedrine, flunarizine, or nitroprusside. 
  • Time to question long-term safety of routine scheduled inhaled beta-2-agonist treatment for COPD. 
  • Tiotropium (Spiriva) for COPD. 
  • Tiotropium bromide step-up therapy for adults with uncontrolled asthma. 
  • Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. 
  • Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. 
  • Treatment of complete heart block with inhaled beta-agonists. 
  • Treatments for pulmonary artery hypertension: show me the outcome! 
  • Unilateral supraglottitis in adults: fact or fiction. 
  • Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques. 
  • Use of aerosolized inhaled epoprostenol in the treatment of portopulmonary hypertension. 
  • Use of lung toxicity and lung particle clearance to estimate the maximum tolerated dose (MTD) for a fiber glass chronic inhalation study in the rat. 
  • Use of nitrite inhalants ("poppers") among American youth. 
  • Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. 
  • Value of an inhalational model of invasive aspergillosis. 
  • Variability in blood flow and pO2 in tumors in response to carbogen breathing. 
  • Variations in Prkdc and susceptibility to benzene-induced toxicity in mice. 
  • Ventilation/perfusion imaging in a rat model of airway obstruction. 
  • alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. 
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  Keywords of People

  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Driehuys, Bastiaan, Professor of Radiology, Physics
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Steinbach, William J., Professor of Pediatrics, Duke Innovation & Entrepreneurship
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine