Administration, Topical

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  Subject Areas on Research

  • A Natural Cream-to-Powder Formulation Developed for the Prevention of Diaper Dermatitis in Diaper-Wearing Infants and Children: Barrier Property and In-Use Tolerance Studies. 
  • A double-blind controlled comparison of generic and trade-name topical steroids using the vasoconstriction assay. 
  • A double-blind, vehicle-controlled study of clobetasol propionate 0.05% (Temovate) scalp application in the treatment of moderate to severe scalp psoriasis. 
  • A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. 
  • A phase III, multicenter, randomized, placebo-controlled clinical trial of topical aminocaproic acid (Caprogel) in the management of traumatic hyphema. 
  • A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. 
  • A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time. 
  • A review of the therapeutic uses of thrombin. 
  • Adrenal suppression following low-dose topical clobetasol propionate. 
  • Adrenal suppression following low-dose topical clobetasol propionate. 
  • Aggressive topical corticosteroid therapy: a novel approach to mast-cell-dependent cutaneous disorders. 
  • Aids for eye drop administration. 
  • Allergic skin disorders. 
  • Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin. 
  • An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model. 
  • An unusual necrotizing dermatitis after a single application of topical benzoin and pressure bandage for enucleation of an eye. 
  • An unusual rearrangement product formed during production of mometasone furoate (Sch 32088). 
  • Antiphospholipid antibodies after surgical exposure to topical bovine thrombin. 
  • Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients. 
  • Antithrombotic potencies of enoxaparin in microvascular surgery: influence of dose and administration methods on patency rate of crushed arterial anastomoses. 
  • Application of energy-based technologies and topical hemostatic agents in the management of surgical hemostasis. 
  • Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. 
  • BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. 
  • Bovine thrombin and systemic autoimmunity. 
  • Brain acetylcholinesterase, acid phosphatase, and 2',3'-cyclic nucleotide-3'-phosphohydrolase and plasma butyrylcholinesterase activities in hens treated with a single dermal neurotoxic dose of S,S,S-tri-n-butyl phosphorotrithioate. 
  • Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy. 
  • Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival. 
  • Can topical ketorolac 0.5% improve the function of Ahmed® glaucoma drainage devices? 
  • Can topical mitomycin prevent laryngotracheal stenosis? 
  • Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. 
  • Capsaicin for the treatment of pain in Guillain-Barré syndrome. 
  • Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. 
  • Central corneal thickness and measured IOP response to topical ocular hypotensive medication in the Ocular Hypertension Treatment Study. 
  • Chemoreduction with topical mitomycin C prior to resection of extensive squamous cell carcinoma of the conjunctiva. 
  • Chronic venous leg ulcer treatment: future research needs. 
  • Chronic wound repair and healing in older adults: current status and future research. 
  • Ciprofloxacin. Use as a topical otic preparation. 
  • Clinical Practice Guideline for the Management of Anal Fissures. 
  • Clinicomicrobiological review of Nocardia keratitis. 
  • Clobetasol propionate versus fluocinonide creams in psoriasis and eczema. 
  • Comparison of antibiotic beads and intravenous antibiotics in open fractures. 
  • Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit. 
  • Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. 
  • Conjunctival intraepithelial neoplasia. 
  • Conjunctival pseudotumor caused by herpes simplex virus infection. 
  • Contact-Lens-Associated Purpureocillium Keratitis: Risk Factors, Microbiologic Characteristics, Clinical Course, and Outcomes. 
  • Corneal neovascularization induced by xenografts or chemical cautery. Inhibition by cyclosporin A. 
  • Coumaphos: delayed neurotoxic effect following dermal administration in hens. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. 
  • Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. 
  • Design of tenofovir-UC781 combination microbicide vaginal gels. 
  • Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography. 
  • Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application. 
  • Disposition, pharmacokinetics, and metabolism of a dermal dose of [14C]2,5-hexanedione in hens. 
  • Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel. 
  • Early aggressive treatment of lichen sclerosus may prevent disease progression. 
  • Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor. 
  • Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. 
  • Effect of topical azithromycin on corneal innate immune responses. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of enoxaparin, standard heparin, and streptokinase on the patency of anastomoses in severely crushed arteries. 
  • Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. 
  • Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. 
  • Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival. 
  • Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats. 
  • Effects of topical corticosteroids on human dermis. 
  • Efficacy and safety of fluticasone propionate 0.005% ointment in the treatment of psoriasis. 
  • Electromyographic, neuropathologic, and functional correlates in the cat as the result of tri-o-cresyl phosphate delayed neurotoxicity. 
  • Endophthalmitis following Nd:YAG laser posterior capsulotomy. 
  • Evaluation and treatment of male and female pattern hair loss. 
  • Evaluation of the Performance of a Nature-Based Sensitive Skin Regimen in Subjects With Clinically Diagnosed Sensitive Skin. 
  • Evaluation of the topical hemostatic efficacy and safety of TISSEEL VH S/D fibrin sealant compared with currently licensed TISSEEL VH in patients undergoing cardiac surgery: a phase 3, randomized, double-blind clinical study. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Exposure to topical apraclonidine in children with glaucoma. 
  • Exposure to topical bovine thrombin during surgery elicits a response against the xenogeneic carbohydrate galactose alpha1-3galactose. 
  • Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits. 
  • Factors affecting pain scores during female urethral catheterization. 
  • Gene expression profiling of cutaneous wound healing. 
  • Generalized pustular psoriasis associated with withdrawal of topical clobetasol-17-propionate. 
  • Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. 
  • Human test models for bioequivalence of topical corticosteroids: a review. 
  • Immunologic impact and clinical outcomes after surgical exposure to bovine thrombin. 
  • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. 
  • Increased 8-hydroxy-2'-deoxyguanosine, a biomarker of oxidative DNA damage in rat urine following a single dermal dose of DEET (N, N-diethyl-m-toluamide), and permethrin, alone and in combination. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Intracavitary mitomycin-C in the treatment of superficial urothelial tumors: a preliminary report. 
  • Intraurethral Steroids are a Safe and Effective Treatment for Stricture Disease in Patients with Biopsy Proven Lichen Sclerosus. 
  • Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial. 
  • Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone. 
  • Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study. 
  • Late acute, delayed neurotoxic and cholinergic effects of S,S,S-tributyl phosphorotrithioite (Merphos) in hens. 
  • Lidocaine as a topical anesthetic for bladder biopsies. 
  • Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial. 
  • Long-term follow-up of men with male pattern baldness treated with topical minoxidil. 
  • Luminal epidermal growth factor preserves mucosal mass of small bowel in fasting rats. 
  • Lyme Disease Serology. 
  • MK-507 versus sezolamide. Comparative efficacy of two topically active carbonic anhydrase inhibitors. 
  • Management of surgical hemostasis: topical agents. 
  • Methicillin-resistant Staphylococcus aureus (MRSA) pediatric tympanostomy tube otorrhea. 
  • MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. 
  • Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. 
  • Nepafenac 0.3% after Cataract Surgery in Patients with Diabetic Retinopathy: Results of 2 Randomized Phase 3 Studies. 
  • Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. 
  • Ocular oxygenation: the effect of phenylephrine on anterior chamber oxygen tension. 
  • Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. 
  • Ocular penetration of 5-fluorocytosine. 
  • Ophthalmologist-patient communication, self-efficacy, and glaucoma medication adherence. 
  • Perilesional and topical interferon alfa-2b for conjunctival and corneal neoplasia. 
  • Periocular necrotizing fasciitis in an infant. 
  • Pharmacokinetics and metabolism of a topically applied dose of O-4-bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioate in hens. 
  • Pityriasis amiantacea: a report of two cases in adults. 
  • Predicted patient demand for a new delivery system for glaucoma medicine. 
  • Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial. 
  • Product comparison model in otolaryngology: Equivalency analysis of absorbable hemostatic agents after endoscopic sinus surgery. 
  • Progression of visual field defects in leber hereditary optic neuropathy: experience of the LHON treatment trial. 
  • Prophylaxis for second eye involvement in leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite. 
  • Provider and patient drivers of ototopical antibiotic prescription variability. 
  • Randomized controlled trial investigating the effect of transcervical papaverine and bupivacaine on postoperative analgesia following laparoscopic sterilization. 
  • Randomized, double-blind, placebo-controlled, patient-initiated study of topical high- and low-dose interferon-alpha with nonoxynol-9 in the treatment of recurrent genital herpes. 
  • Rapid corneal adrenochrome deposition from topical ibopamine in the setting of infectious keratitis. 
  • Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren's syndrome. 
  • Reduction of exit-site infections of tunnelled intravascular catheters among neutropenic patients by sustained-release chlorhexidine dressings: results from a prospective randomized controlled trial. 
  • Results of trabeculectomy with 0.3 mg/ml mitomycin C titrating exposure times based on risk factors for failure. 
  • SAVVY (C31G) gel for prevention of HIV infection in women: a Phase 3, double-blind, randomized, placebo-controlled trial in Ghana. 
  • Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus. 
  • Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. 
  • Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab. 
  • Serum lidocaine concentrations in asthmatics undergoing research bronchoscopy. 
  • Skin antisepsis: it's not only what you use, it's the way that you use it. 
  • Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery. 
  • Statistical analysis of skin tumor data from Tg.AC mouse bioassays. 
  • Steroid-induced glaucoma in a young woman. 
  • Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. 
  • Systematic review of topical antimicrobial therapy for acute otitis externa. 
  • Systemic reactions to imiquimod (Aldara). 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. 
  • The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. 
  • The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. 
  • The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. 
  • The Use of Systemic and Topical Fluoroquinolones. 
  • The Use of Topical Hemostatic Agents in Cardiothoracic Surgery. 
  • The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens: potentiating effect. 
  • The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia. 
  • Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial. 
  • Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata. 
  • Topical Imiquimod in the Treatment of Conjunctival Actinic Keratosis. 
  • Topical Therapy Primer for Nondermatologists. 
  • Topical aminocaproic acid significantly reduces the incidence of secondary hemorrhage in traumatic hyphema in the rabbit model. 
  • Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. 
  • Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial. 
  • Topical application of WR-2721 to prevent radiation-induced proctosigmoiditis. A phase I/II trial. 
  • Topical bevacizumab therapy for corneal neovascularization. 
  • Topical clobetasol-17-propionate: review of its clinical efficacy and safety. 
  • Topical conjunctival corticosteroid therapy for malignant atrophic papulosis (Kohlmeier-Degos disease). 
  • Topical fibronectin and corneal epithelial wound healing in the rabbit. 
  • Topical methotrexate therapy for psoriasis. 
  • Topical microbicides: the time has come. 
  • Topical minoxidil in early male pattern baldness. 
  • Topical minoxidil in male pattern baldness: effects of discontinuation of treatment. 
  • Topical minoxidil in the treatment of androgenetic alopecia in women. 
  • Topical oxygen is not hyperbaric oxygen (HBO2). 
  • Topical thrombin and acquired coagulation factor inhibitors: clinical spectrum and laboratory diagnosis. 
  • Topical tretinoin therapy and all-cause mortality. 
  • Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma. 
  • Topically applied aminocaproic acid concentrates in the aqueous humor of the rabbit in therapeutic levels. 
  • Transdermal administration of nicotine. 
  • Treatment of chemotherapy-induced alopecia. 
  • Treatment of hypergranulation tissue with high potency topical corticosteroids in children. 
  • Treatment of urticaria pigmentosa with corticosteroids. 
  • Treatment of xerophthalmia with retinol, tretinoin, and etretinate. 
  • Tretinoin and the prevention of keratinocyte carcinoma (Basal and squamous cell carcinoma of the skin): a veterans affairs randomized chemoprevention trial. 
  • Tretinoin emollient cream: a new therapy for photodamaged skin. 
  • Urticaria pigmentosa. Systemic evaluation and successful treatment with topical steroids. 
  • Use of ototopical antibiotics in treating 3 common ear diseases. 
  • Vancomycin levels in human aqueous humour after intravenous and subconjunctival administration. 
  • Vasodilator action of prostaglandin E1 on microcirculation of rat cremaster muscle. 
  • Visual experience during phacoemulsification under topical versus retrobulbar anesthesia: results of a prospective, randomized, controlled trial. 
  • Warning! Masoprocol is a potent sensitizer. 
  • Wound healing and treating wounds: Chronic wound care and management. 
  • Wound hematoma: prophylaxis with topical thrombin. 
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  Keywords of People

  • Katz, David F., Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering