Afferent Pathways

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  Subject Areas on Research

  • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 
  • A Neural Circuit for Gut-Induced Reward. 
  • A craniofacial-specific monosynaptic circuit enables heightened affective pain. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A functional division of Drosophila sweet taste neurons that is value-based and task-specific. 
  • A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. 
  • A sweet spot for the bariatric surgeon. 
  • A urethral afferent mediated excitatory bladder reflex exists in humans. 
  • Afferent influences on brain stem auditory nuclei of the chicken: effects of conductive and sensorineural hearing loss on n. magnocellularis. 
  • Auditory plasticity in a basal ganglia-forebrain pathway during decrystallization of adult birdsong. 
  • Autoradiographic evidence that septohippocampal fibers reinnervate fascia dentata denervated by entorhinal lesion during development. 
  • Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations. 
  • Benzodiazepine receptor declines in hippocampal formation following limbic seizures. 
  • Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention. 
  • Bladder activation by selective stimulation of pudendal nerve afferents in the cat. 
  • CNS location of uterine-related neurons revealed by trans-synaptic tracing with pseudorabies virus and their relation to estrogen receptor-immunoreactive neurons. 
  • Characteristics of antidromically identified oculomotor internuclear neurons during vergence and versional eye movements. 
  • Clinical issues in considering vagus nerve stimulation for treatment-resistant depression. 
  • Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. 
  • Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit. 
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level. 
  • Course and laminar origin of the tectoparabigeminal pathway. 
  • Cross-modal selective attention effects on retinal, myogenic, brainstem, and cerebral evoked potentials. 
  • Descending projections from the superior olivary complex to the cochlear nucleus of the cat. 
  • Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Effects of conductive hearing loss on gerbil central auditory system activity in silence. 
  • Effects of deafferentation on the electrophysiology of ventral cochlear nucleus neurons. 
  • Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats. 
  • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. 
  • Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits. 
  • Electrical stimulation for control of bladder function. 
  • Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation. 
  • Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. 
  • Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. 
  • Finite element modeling and in vivo analysis of electrode configurations for selective stimulation of pudendal afferent fibers. 
  • Firing rate of the noisy quadratic integrate-and-fire neuron. 
  • Floccular efferents in the rhesus macaque as revealed by autoradiography and horseradish peroxidase. 
  • Frequency-dependent selection of reflexes by pudendal afferents in the cat. 
  • From hippocampus to whole-brain: The role of integrative processing in episodic memory retrieval. 
  • GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus. 
  • Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE). 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. 
  • Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. 
  • Innervation patterns of single physiologically identified geniculocortical axons in the striate cortex of the tree shrew. 
  • Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion. 
  • Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity. 
  • Intraurethral stimulation evokes bladder responses via 2 distinct reflex pathways. 
  • Intrinsic connections of macaque striate cortex: afferent and efferent connections of lamina 4C. 
  • Ipsilateral subcortical atrophy associated with temporal lobectomy. 
  • Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways. 
  • Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation. 
  • Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells. 
  • Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain. 
  • Laminar origin of ipsilateral tectopontine pathways. 
  • Layer-specific somatosensory cortical activation during active tactile discrimination. 
  • Lesions of excitatory pathways reduce hippocampal cell death after transient forebrain ischemia in the gerbil. 
  • Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid. 
  • Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons. 
  • Mechanisms of reflex bladder activation by pudendal afferents. 
  • Modeling the spinal pudendo-vesical reflex for bladder control by pudendal afferent stimulation. 
  • Modulation of experimental arthritis by vagal sensory and central brain stimulation. 
  • More than a rhythm of life: breathing as a binder of orofacial sensation. 
  • Multiple pudendal sensory pathways reflexly modulate bladder and urethral activity in patients with spinal cord injury. 
  • Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. 
  • Neural control of the urethra. 
  • Neural mechanism of acupuncture-induced gastric relaxations in rats. 
  • Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. 
  • Olfactory marker protein mRNA is found in axons of olfactory receptor neurons. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Optimal information storage and the distribution of synaptic weights: perceptron versus Purkinje cell. 
  • Pathway from the zona incerta to the superior colliculus in the rat. 
  • Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats. 
  • Phasic activation of the external urethral sphincter increases voiding efficiency in the rat and the cat. 
  • Physiological properties of vestibular primary afferents that mediate motor learning and normal performance of the vestibulo-ocular reflex in monkeys. 
  • Physiological properties of vestibular primary afferents that mediate motor learning and normal performance of the vestibulo-ocular reflex in monkeys. 
  • Projections from the superior colliculus to the dorsal lateral geniculate nucleus of the grey squirrel (Sciurus carolinensis). 
  • Receptors, circuits, and behaviors: new directions in chemical senses. 
  • Regulation of hippocampal sympathetic ingrowth: role of afferent input. 
  • Retention of VOR gain following short-term VOR adaptation. 
  • Saccades to somatosensory targets. I. behavioral characteristics. 
  • Saccades to somatosensory targets. II. motor convergence in primate superior colliculus. 
  • Saccades to somatosensory targets. III. eye-position-dependent somatosensory activity in primate superior colliculus. 
  • Selective co-stimulation of pudendal afferents enhances bladder activation and improves voiding efficiency. 
  • Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Sensory and circuit mechanisms mediating lower urinary tract reflexes. 
  • Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. 
  • Serotonergic modulation of bladder afferent pathways. 
  • Somatotopic maps within the zona incerta relay parallel GABAergic somatosensory pathways to the neocortex, superior colliculus, and brainstem. 
  • Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. 
  • Spinal micturition reflex mediated by afferents in the deep perineal nerve. 
  • Structural mapping with fiber tractography of the human cuneate fasciculus at microscopic resolution in cervical region. 
  • Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. 
  • Subcortical connections of the superior colliculus in the mustache bat, Pteronotus parnellii. 
  • Sympathetic response to intracranial NGF infusion in the absence of afferent input: axonal sprouting without neurotransmitter production. 
  • Tapered Polymer Whiskers to Enable Three-Dimensional Tactile Feature Extraction. 
  • Taste perception: how to make a gourmet mouse. 
  • Temporal pattern of stimulation modulates reflex bladder activation by pudendal nerve stimulation. 
  • Thalamocortical [correction of Thalamcortical] optimization of tactile processing according to behavioral state. 
  • The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. 
  • The gustatory cortex and multisensory integration. 
  • The laminar organization of the lateral geniculate body and the striate cortex in the squirrel monkey (Saimiri sciureus). 
  • The laminar organization of the lateral geniculate body and the striate cortex in the tree shrew (Tupaia glis). 
  • The laminar origin and distribution of the crossed tectoreticular pathways. 
  • The neural mechanisms of gustation: a distributed processing code. 
  • The organization of the pulvinar in the grey squirrel (Sciurus carolinensis). I. Cytoarchitecture and connections. 
  • The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor. 
  • The role of protein synthesis in striatal long-term depression. 
  • The sources of the nigrotectal pathway. 
  • Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover. 
  • Transformation of vestibular signals into motor commands in the vestibuloocular reflex pathways of monkeys. 
  • Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice. 
  • Urethral flow-responsive afferents in the cat sacral dorsal root ganglia. 
  • Visual motion processing for the initiation of smooth-pursuit eye movements in humans. 
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  Keywords of People

  • Clendaniel, Richard Alan, Assistant Professor in Orthopaedic Surgery, Head and Neck Surgery & Communication Sciences
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Distinguished Professor in Neuroscience, Neurobiology