Alcohol Dehydrogenase

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  Subject Areas on Research

  • A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. 
  • A small-molecule antagonist of the hedgehog signaling pathway. 
  • Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. 
  • Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx. 
  • Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. 
  • Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. 
  • Chemico-Biological Interactions. Enzymology and molecular biology of carbonyl metabolism 16. Introduction. 
  • Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae). 
  • DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster. 
  • Depression of alcohol dehydrogenase activity in rat hepatocyte culture by dihydrotestosterone. 
  • Differential induction of mRNAs for the glycolytic and ethanolic fermentative pathways by hypoxia and anoxia in maize seedlings. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans. 
  • Gateway-compatible tissue-specific vectors for plant transformation. 
  • Genome annotation assessment in Drosophila melanogaster. 
  • Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria. 
  • Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation. 
  • Identification of an X-ray induced deletion mutant flanked by direct repeats. 
  • Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster. 
  • Molecular analysis of Drosophila melanogaster AdhnLA405 confirms reliability of DNA-sequencing methodology. 
  • Molecular analysis of X-ray-induced alcohol dehydrogenase (ADH) null mutations in Drosophila melanogaster. 
  • Molecular analysis of alcohol dehydrogenase electromorphs in wild type and transformed Drosophila melanogaster. 
  • Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. 
  • Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. 
  • Promoter prediction on a genomic scale--the Adh experience. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. 
  • Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. 
  • S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria. 
  • S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy. 
  • Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase. 
  • Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. 
  • The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies. 
  • The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo. 
  • The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. 
  • Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. 
  • Zeta-crystallin versus other members of the alcohol dehydrogenase super-family. Variability as a functional characteristic. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology