Aldehydes

• 

  Subject Areas on Research

  • A formal synthesis of SCH 351448. 
  • A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. 
  • A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation. 
  • Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry. 
  • Amine-aldehyde metabolites and alcoholism: fact, myth or uncertainty. 
  • Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. 
  • Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet. 
  • Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. 
  • Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors. 
  • Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products. 
  • Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells. 
  • Combining lung-protective strategies in experimental acute lung injury: The impact of high-frequency partial liquid ventilation. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Cutaneous herpes simplex virus infection of guinea pigs as a model for antiviral chemotherapy. 
  • Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. 
  • Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver. 
  • Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. 
  • E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. 
  • Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. 
  • Effects of garage employment and tobacco smoking on breathing-zone concentrations of carbonyl compounds. 
  • Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. 
  • Expanding the synthetic method and structural diversity potential for the intramolecular Aza Diels-Alder cyclization. 
  • Flavorant-Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol. 
  • Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Impacts of a nanosized ceria additive on diesel engine emissions of particulate and gaseous pollutants. 
  • Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide. 
  • LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH). 
  • Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. 
  • Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. 
  • Optimizing a dansylhydrazine (DNSH) based method for measuring airborne acrolein and other unsaturated carbonyls. 
  • Orientation of acidic polysaccharides and rhodopsin-oligosaccharides in frog retinal rod outer segments. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Oxidative stress and covalent modification of protein with bioactive aldehydes. 
  • Ozone-initiated chemistry in an occupied simulated aircraft cabin. 
  • Personal and ambient exposures to air toxics in Camden, New Jersey. 
  • Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb. 
  • Purification, characterization, and structural elucidation of the active moiety of the previously called "suppressor activating factor (SAF)". 
  • Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment. 
  • STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS. 
  • Sources of volatile organic compounds in suburban homes in Shanghai, China, and the impact of air filtration on compound concentrations 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing. 
  • Targeting aldehyde dehydrogenase: a potential approach for cell labeling. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Using charcoal as base material reduces mosquito coil emissions of toxins. 
  • Using isotopic tools to dissect and quantitate parallel metabolic pathways. 
  • Vapor detection and discrimination with a panel of odorant receptors. 
  • X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. 
  • β-Cyclocitral is a conserved root growth regulator. 
• 

  Keywords of People

  • Meyer, Joel, Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Nicholas Institute-Energy Initiative